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MED1 MED1 NR0B1 NR0B1 HNF4G HNF4G HNF4A HNF4A ENSMFAP00000021707 ENSMFAP00000021707 ESRRA ESRRA NR2E3 NR2E3 RORA RORA NR5A1 NR5A1 NR2F6 NR2F6 RXRA RXRA NR1I3 NR1I3 NR2C2 NR2C2 NR4A1 NR4A1 NR6A1 NR6A1 NR2F1 NR2F1 NR2C2AP NR2C2AP PGR PGR AR AR ESR2 ESR2 PPARD PPARD RXRB RXRB NR4A2 NR4A2 PPARG PPARG NCOR1 NCOR1 NR1D1 NR1D1 VDR VDR NR1D2 NR1D2 RARA RARA RARB RARB RORB RORB CEP55 CEP55 ENSMFAP00000042405 ENSMFAP00000042405 ESR1 ESR1 NR1H2 NR1H2 C1orf56 C1orf56 NR3C1 NR3C1 NR2E1 NR2E1 NR4A3 NR4A3 NR1H3 NR1H3 RXRG RXRG NR1H4 NR1H4 NCOR2 NCOR2 NR0B2 NR0B2 NR3C2 NR3C2 NR1I2 NR1I2 NR5A2 NR5A2 ESRRB ESRRB RORC RORC NR2C1 NR2C1 ESRRG ESRRG THRB THRB RARG RARG NRBP1 NRBP1 CCDC134 CCDC134 PPARA PPARA NRBF2 NRBF2 THRA THRA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (470 aa)
HNF4GHepatocyte nuclear factor 4 gamma. (455 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
ENSMFAP00000021707Nuclear receptor domain-containing protein. (255 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
NR2E3Nuclear receptor subfamily 2 group E member 3. (462 aa)
RORARAR related orphan receptor A. (555 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
NR2F6Nuclear receptor subfamily 2 group F member 6. (404 aa)
RXRARetinoid X receptor alpha. (443 aa)
NR1I3Nuclear receptor subfamily 1 group I member 3. (357 aa)
NR2C2Nuclear receptor subfamily 2 group C member 2. (619 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (670 aa)
NR6A1Nuclear receptor subfamily 6 group A member 1. (457 aa)
NR2F1Nuclear receptor subfamily 2 group F member 1. (423 aa)
NR2C2APNuclear receptor 2C2 associated protein. (167 aa)
PGRProgesterone receptor. (936 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa)
ESR2Estrogen receptor 2. (530 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
RXRBRetinoid X receptor beta. (537 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
VDRVitamin D receptor. (477 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (580 aa)
RARARetinoic acid receptor alpha. (462 aa)
RARBRetinoic acid receptor beta. (448 aa)
RORBRAR related orphan receptor B. (475 aa)
CEP55Centrosomal protein 55. (464 aa)
ENSMFAP00000042405Uncharacterized protein. (232 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
C1orf56Chromosome 1 open reading frame 56. (341 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (778 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
RXRGRetinoid X receptor gamma. (463 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
NCOR2Nuclear receptor corepressor 2. (2510 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
NR3C2Nuclear receptor subfamily 3 group C member 2. (988 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (473 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
ESRRBEstrogen related receptor beta. (438 aa)
RORCRAR related orphan receptor C. (518 aa)
NR2C1Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] (603 aa)
ESRRGEstrogen related receptor gamma. (470 aa)
THRBUncharacterized protein. (476 aa)
RARGRetinoic acid receptor gamma. (454 aa)
NRBP1Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (543 aa)
CCDC134Coiled-coil domain containing 134. (229 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
NRBF2Nuclear receptor binding factor 2. (289 aa)
THRAUncharacterized protein. (602 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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