STRINGSTRING
EFNB3 EFNB3 FYN FYN ENSMFAP00000001080 ENSMFAP00000001080 EPHA7 EPHA7 EFNB2 EFNB2 PSEN1 PSEN1 PSEN2 PSEN2 CLTB CLTB EPHB1 EPHB1 TIAM1 TIAM1 EPHA8 EPHA8 EPHA6 EPHA6 PSENEN PSENEN EFNA4 EFNA4 APH1A APH1A ELSPBP1 ELSPBP1 ACTL7A ACTL7A ACTL7B ACTL7B ACTRT2 ACTRT2 ACTRT1 ACTRT1 AP2M1 AP2M1 AP2S1 AP2S1 ENSMFAP00000013586 ENSMFAP00000013586 ACTG1 ACTG1 DNM1 DNM1 VAV3 VAV3 MMP9 MMP9 EPHA3 EPHA3 AP2A2 AP2A2 ACTB ACTB SRC SRC CLTCL1 CLTCL1 FNDC3A FNDC3A AP2B1 AP2B1 FNDC3B FNDC3B EPHB4 EPHB4 EFNB1 EFNB1 LYN LYN EPHA2 EPHA2 CLTA CLTA EPHA10 EPHA10 AP2A1 AP2A1 EFNA3 EFNA3 EPHB3 EPHB3 EPHA4 EPHA4 MMP2 MMP2 EPHA5 EPHA5 YES1 YES1 EPHB2 EPHB2 NCSTN NCSTN ADAM10 ADAM10 VAV2 VAV2 EFNA2 EFNA2 ENSMFAP00000037181 ENSMFAP00000037181 EPHA1 EPHA1 ENSMFAP00000040574 ENSMFAP00000040574 EFNA1 EFNA1 CLTC CLTC EPHB6 EPHB6 APH1B APH1B EFNA5 EFNA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
FYNTyrosine-protein kinase. (537 aa)
ENSMFAP00000001080Uncharacterized protein; Belongs to the actin family. (354 aa)
EPHA7EPH receptor A7. (998 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
EPHB1EPH receptor B1. (984 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
EPHA8EPH receptor A8. (999 aa)
EPHA6EPH receptor A6. (1131 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (201 aa)
APH1AUncharacterized protein. (265 aa)
ELSPBP1Epididymal sperm binding protein 1. (223 aa)
ACTL7AActin-like protein 7A; Belongs to the actin family. (435 aa)
ACTL7BActin-like protein 7B. (415 aa)
ACTRT2Actin-related protein T2. (377 aa)
ACTRT1Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family. (350 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
ENSMFAP00000013586Uncharacterized protein; Belongs to the actin family. (257 aa)
ACTG1Uncharacterized protein. (377 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
EPHA3EPH receptor A3. (984 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (940 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (379 aa)
SRCTyrosine-protein kinase. (542 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1640 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
AP2B1AP complex subunit beta. (951 aa)
FNDC3BFibronectin type III domain containing 3B. (1206 aa)
EPHB4EPH receptor B4. (987 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
LYNTyrosine-protein kinase. (512 aa)
EPHA2Ephrin type-A receptor 2; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin- A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DS [...] (1036 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
EPHA10Eph LBD domain-containing protein. (295 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
EFNA3Ephrin A3; Belongs to the ephrin family. (240 aa)
EPHB3EPH receptor B3. (1008 aa)
EPHA4EPH receptor A4. (986 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
EPHA5EPH receptor A5. (1038 aa)
YES1Tyrosine-protein kinase. (548 aa)
EPHB2Uncharacterized protein. (468 aa)
NCSTNNcstrn_small domain-containing protein. (721 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (181 aa)
ENSMFAP00000037181Uncharacterized protein; Belongs to the actin family. (163 aa)
EPHA1EPH receptor A1. (978 aa)
ENSMFAP00000040574Uncharacterized protein. (130 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
EPHB6EPH receptor B6. (1017 aa)
APH1BUncharacterized protein. (257 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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