STRINGSTRING
VANGL2 VANGL2 ENSMFAP00000001720 ENSMFAP00000001720 PSMD3 PSMD3 DVL3 DVL3 PSMA5 PSMA5 PSMA7 PSMA7 PSMD4 PSMD4 RAC2 RAC2 FZD8 FZD8 DVL2 DVL2 CLTC CLTC PSMB1 PSMB1 PRICKLE2 PRICKLE2 DAAM2 DAAM2 WNT5B WNT5B ENSMFAP00000042309 ENSMFAP00000042309 PSMD11 PSMD11 UBB UBB ROR1 ROR1 ENSMFAP00000040580 ENSMFAP00000040580 PSME3 PSME3 ENSMFAP00000039848 ENSMFAP00000039848 WNT4 WNT4 PSMD7 PSMD7 PSMD10 PSMD10 FZD2 FZD2 PSMB9 PSMB9 PSMD2 PSMD2 RPS27A RPS27A PRICKLE3 PRICKLE3 WNT1 WNT1 PSMC4 PSMC4 FZD4 FZD4 PRICKLE4 PRICKLE4 WNT5A WNT5A ENSMFAP00000035194 ENSMFAP00000035194 PSMC3 PSMC3 ENSMFAP00000034968 ENSMFAP00000034968 ENSMFAP00000034774 ENSMFAP00000034774 PSME4 PSME4 PSMD5 PSMD5 PSMC1 PSMC1 PSMA3 PSMA3 PSMD9 PSMD9 PSMC6 PSMC6 PSMA1 PSMA1 PSMB10 PSMB10 PRKCG PRKCG PSMC2 PSMC2 AP2A1 AP2A1 SCRIB SCRIB RAC1 RAC1 ENSMFAP00000027900 ENSMFAP00000027900 CLTA CLTA PSMB6 PSMB6 KXD1 KXD1 RYK RYK FZD3 FZD3 PSMC5 PSMC5 PSMA6 PSMA6 ENSMFAP00000023218 ENSMFAP00000023218 WNT11 WNT11 PSME1 PSME1 ENSMFAP00000021715 ENSMFAP00000021715 DVL1 DVL1 SMURF1 SMURF1 PSMB4 PSMB4 AP2B1 AP2B1 PSMD12 PSMD12 PSMA2 PSMA2 PSMD13 PSMD13 PSMD8 PSMD8 ENSMFAP00000017668 ENSMFAP00000017668 AP2A2 AP2A2 ENSMFAP00000015936 ENSMFAP00000015936 PRKCB PRKCB ROR2 ROR2 DAAM1 DAAM1 PARD6A PARD6A FZD7 FZD7 LOC102117118 LOC102117118 PRKCA PRKCA ENSMFAP00000012842 ENSMFAP00000012842 AP2S1 AP2S1 AP2M1 AP2M1 PRICKLE1 PRICKLE1 ENSMFAP00000012290 ENSMFAP00000012290 ENSMFAP00000011989 ENSMFAP00000011989 ENSMFAP00000011880 ENSMFAP00000011880 ENSMFAP00000011762 ENSMFAP00000011762 FZD5 FZD5 PSMA8 PSMA8 PSMB11 PSMB11 LOC101864869 LOC101864869 UBC UBC RAC3 RAC3 ENSMFAP00000010019 ENSMFAP00000010019 ENSMFAP00000009883 ENSMFAP00000009883 ENSMFAP00000009536 ENSMFAP00000009536 ARRB2 ARRB2 FZD6 FZD6 PSME2 PSME2 PSMB5 PSMB5 SMURF2 SMURF2 PSMB3 PSMB3 FHDC1 FHDC1 ENSMFAP00000006175 ENSMFAP00000006175 PSMF1 PSMF1 PSMD1 PSMD1 PSMB8 PSMB8 PSMB7 PSMB7 ENSMFAP00000005841 ENSMFAP00000005841 ENSMFAP00000005693 ENSMFAP00000005693 PSMB2 PSMB2 PSMD14 PSMD14 PSMA4 PSMA4 ENSMFAP00000004537 ENSMFAP00000004537 CLTB CLTB ENSMFAP00000003583 ENSMFAP00000003583 PSMD6 PSMD6 RHOA RHOA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VANGL2Vang-like protein. (539 aa)
ENSMFAP00000001720AAA domain-containing protein; Belongs to the AAA ATPase family. (384 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMA7Proteasome subunit alpha type-7-like; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removi [...] (248 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (403 aa)
RAC2Rac family small GTPase 2. (192 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
PSMB1Proteasome subunit beta. (241 aa)
PRICKLE2Prickle planar cell polarity protein 2. (900 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
ENSMFAP00000042309Uncharacterized protein. (191 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
UBBUncharacterized protein. (219 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (923 aa)
ENSMFAP00000040580Uncharacterized protein. (507 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa)
ENSMFAP00000039848MPN domain-containing protein. (149 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (562 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (912 aa)
RPS27ABrain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa)
PRICKLE3Prickle planar cell polarity protein 3. (620 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PSMC426S proteasome regulatory subunit 6B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated wit [...] (418 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (524 aa)
PRICKLE4Uncharacterized protein. (385 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSMFAP00000035194AAA domain-containing protein; Belongs to the AAA ATPase family. (418 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (451 aa)
ENSMFAP00000034968Uncharacterized protein. (180 aa)
ENSMFAP00000034774Uncharacterized protein. (158 aa)
PSME4Proteasome activator subunit 4. (1844 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity). (508 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMD9PDZ domain-containing protein. (223 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
PSMA1Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (269 aa)
PSMB10Proteasome subunit beta. (273 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
PSMC226S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
SCRIBScribble planar cell polarity protein. (1662 aa)
RAC1Uncharacterized protein. (213 aa)
ENSMFAP00000027900ANK_REP_REGION domain-containing protein. (163 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
PSMB6Proteasome subunit beta. (250 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa)
RYKReceptor like tyrosine kinase. (585 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PSMC526S proteasome regulatory subunit T6; Belongs to the AAA ATPase family. (406 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
ENSMFAP00000023218AAA domain-containing protein; Belongs to the AAA ATPase family. (366 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
PSME1Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (249 aa)
ENSMFAP00000021715Proteasome subunit alpha type. (174 aa)
DVL1Dishevelled segment polarity protein 1. (673 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
AP2B1AP complex subunit beta. (951 aa)
PSMD12PCI domain-containing protein. (456 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMD13PCI domain-containing protein. (399 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (334 aa)
ENSMFAP00000017668Uncharacterized protein. (182 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (940 aa)
ENSMFAP00000015936Ubiquitin-like domain-containing protein. (144 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1078 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
LOC102117118Ubiquitin-like domain-containing protein. (127 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ENSMFAP00000012842Proteasome endopeptidase complex. (217 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
PRICKLE1Prickle planar cell polarity protein 1. (831 aa)
ENSMFAP00000012290Ubiquitin-like domain-containing protein. (156 aa)
ENSMFAP00000011989Uncharacterized protein; Belongs to the AAA ATPase family. (398 aa)
ENSMFAP00000011880Ubiquitin-like domain-containing protein. (128 aa)
ENSMFAP00000011762ANK_REP_REGION domain-containing protein. (116 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
PSMA8Proteasome endopeptidase complex. (132 aa)
PSMB11Proteasome subunit beta. (300 aa)
LOC101864869Ubiquitin-like domain-containing protein. (156 aa)
UBCUbiquitin C. (645 aa)
RAC3Rac family small GTPase 3. (180 aa)
ENSMFAP00000010019ANK_REP_REGION domain-containing protein. (159 aa)
ENSMFAP00000009883Ubiquitin-like domain-containing protein. (147 aa)
ENSMFAP00000009536Proteasome subunit alpha type. (236 aa)
ARRB2Arrestin beta 2. (454 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSMB5Proteasome subunit beta. (263 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
PSMB3Proteasome subunit beta. (205 aa)
FHDC1FH2 domain containing 1. (1149 aa)
ENSMFAP00000006175AAA domain-containing protein. (372 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMB7Proteasome subunit beta. (302 aa)
ENSMFAP00000005841Ubiquitin-like domain-containing protein. (122 aa)
ENSMFAP00000005693CSN8_PSD8_EIF3K domain-containing protein. (226 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD1426S proteasome regulatory subunit N11. (310 aa)
PSMA4Proteasome subunit alpha type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (261 aa)
ENSMFAP00000004537Prot_ATP_ID_OB domain-containing protein. (166 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
ENSMFAP00000003583Uncharacterized protein. (379 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
RHOAUncharacterized protein. (141 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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