STRINGSTRING
KCNG2 KCNG2 ENSMFAP00000000823 ENSMFAP00000000823 ADCY6 ADCY6 GNGT1 GNGT1 ADCY8 ADCY8 MARCKS MARCKS CACNA1E CACNA1E RAPGEFL1 RAPGEFL1 SNAP25 SNAP25 GNG13 GNG13 CACNA2D2 CACNA2D2 ENSMFAP00000005412 ENSMFAP00000005412 RAPGEF5 RAPGEF5 THAP7 THAP7 ENSMFAP00000006047 ENSMFAP00000006047 GNG4 GNG4 STX1A STX1A GNGT2 GNGT2 INS INS PRKACA PRKACA KCNS3 KCNS3 KCNJ11 KCNJ11 FFAR1 FFAR1 PRKCA PRKCA ENSMFAP00000013772 ENSMFAP00000013772 GNB3 GNB3 GNG5 GNG5 PRKACG PRKACG PRKAR1A PRKAR1A VAMP2 VAMP2 CACNB2 CACNB2 SLC2A1 SLC2A1 GNAI2 GNAI2 KCNC2 KCNC2 ENSMFAP00000020180 ENSMFAP00000020180 GNG11 GNG11 ITPR2 ITPR2 ENSMFAP00000022223 ENSMFAP00000022223 ABCC8 ABCC8 GNA14 GNA14 ADRA2A ADRA2A ACSL3 ACSL3 GNG12 GNG12 PLCB1 PLCB1 FAP FAP GNAS GNAS PRKACB PRKACB CD36 CD36 IQGAP1 IQGAP1 GNG8 GNG8 AHCYL1 AHCYL1 RAPGEF4 RAPGEF4 PLCB3 PLCB3 CACNA2D1 CACNA2D1 THAP6 THAP6 PRKAR2A PRKAR2A CACNB3 CACNB3 ENSMFAP00000029969 ENSMFAP00000029969 ITPR1 ITPR1 CACNA1F CACNA1F CACNA1C CACNA1C PLCB2 PLCB2 SYT5 SYT5 PRKAR1B PRKAR1B ADCY5 ADCY5 KCNB1 KCNB1 GNB5 GNB5 ADRA2C ADRA2C GNG7 GNG7 GNAQ GNAQ GLP1R GLP1R RAP1A RAP1A RAPGEF3 RAPGEF3 STXBP1 STXBP1 GNG2 GNG2 SLC2A2 SLC2A2 GNA15 GNA15 GNA11 GNA11 GNB4 GNB4 GCG GCG PRKAR2B PRKAR2B GNG10 GNG10 ITPR3 ITPR3 GNB1 GNB1 ENSMFAP00000042978 ENSMFAP00000042978 GNB2 GNB2 GNG3 GNG3 CACNA1A CACNA1A CACNA1D CACNA1D ACSL4 ACSL4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNG2Potassium voltage-gated channel modifier subfamily G member 2; Belongs to the potassium channel family. (422 aa)
ENSMFAP00000000823G protein gamma domain-containing protein. (73 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (281 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2412 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (662 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1134 aa)
ENSMFAP00000005412Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (883 aa)
THAP7THAP domain containing 7. (309 aa)
ENSMFAP00000006047Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
FFAR1Free fatty acid receptor 1; G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular c [...] (300 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ENSMFAP00000013772Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNB3G protein subunit beta 3. (340 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
PRKAR1AUncharacterized protein. (381 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (118 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
ENSMFAP00000020180Uncharacterized protein. (375 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ENSMFAP00000022223Cyclic nucleotide-binding domain-containing protein. (81 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
GNA14G protein subunit alpha 14. (355 aa)
ADRA2AAdrenoceptor alpha 2A. (465 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
GNASGNAS complex locus. (1023 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1696 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
THAP6THAP domain containing 6. (222 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (401 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
ENSMFAP00000029969Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
CACNA1CCalcium voltage-gated channel subunit alpha1 C. (1987 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
SYT5Brain cDNA, clone: QccE-17821, similar to human synaptotagmin V (SYT5). (386 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (313 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
GNB5G protein subunit beta 5. (409 aa)
ADRA2CAdrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family. (365 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAQG protein subunit alpha q. (359 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (625 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
GNA15G protein subunit alpha 15. (330 aa)
GNA11G protein subunit alpha 11. (359 aa)
GNB4G protein subunit beta 4. (340 aa)
GCGGlucagon. (180 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
GNB1G protein subunit beta 1. (340 aa)
ENSMFAP00000042978G protein gamma domain-containing protein. (63 aa)
GNB2WD_REPEATS_REGION domain-containing protein. (375 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2370 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.