STRINGSTRING
LOC102146894 LOC102146894 G8F2Z2_MACFA G8F2Z2_MACFA H2BC5 H2BC5 DNMT1 DNMT1 ENSMFAP00000012784 ENSMFAP00000012784 ENSMFAP00000012416 ENSMFAP00000012416 GTF2H4 GTF2H4 H2BU1 H2BU1 ENSMFAP00000012162 ENSMFAP00000012162 ENSMFAP00000012034 ENSMFAP00000012034 LOC102130997 LOC102130997 H3C1 H3C1 H2AJ H2AJ ENSMFAP00000011563 ENSMFAP00000011563 ENSMFAP00000011394 ENSMFAP00000011394 H2AC7 H2AC7 G7P2P1_MACFA G7P2P1_MACFA ENSMFAP00000011138 ENSMFAP00000011138 ENSMFAP00000010884 ENSMFAP00000010884 ENSMFAP00000010867 ENSMFAP00000010867 ENSMFAP00000010848 ENSMFAP00000010848 H2AC6 H2AC6 CCNH CCNH H2AX H2AX ENSMFAP00000010686 ENSMFAP00000010686 H2BC11 H2BC11 ENSMFAP00000010627 ENSMFAP00000010627 ENSMFAP00000010517 ENSMFAP00000010517 CD3EAP CD3EAP ENSMFAP00000010148 ENSMFAP00000010148 H2AC20 H2AC20 H2BC1 H2BC1 ENSMFAP00000010040 ENSMFAP00000010040 ENSMFAP00000010034 ENSMFAP00000010034 ENSMFAP00000010006 ENSMFAP00000010006 SAP18 SAP18 ENSMFAP00000009974 ENSMFAP00000009974 H2BC14 H2BC14 HIST1H2BO HIST1H2BO LOC102147067 LOC102147067 HIST1H3B HIST1H3B MNAT1 MNAT1 HDAC1 HDAC1 ENSMFAP00000008526 ENSMFAP00000008526 SAP30BP SAP30BP SAP30L SAP30L DNMT3B DNMT3B TAF1A TAF1A ENSMFAP00000043974 ENSMFAP00000043974 TAF1D TAF1D BAZ2B BAZ2B ENSMFAP00000043498 ENSMFAP00000043498 HDAC2 HDAC2 ENSMFAP00000001505 ENSMFAP00000001505 LOC102121517 LOC102121517 LOC102138275 LOC102138275 ENSMFAP00000002027 ENSMFAP00000002027 H2AZ2 H2AZ2 CDK7 CDK7 POLR2L POLR2L ENSMFAP00000004828 ENSMFAP00000004828 SMARCA1 SMARCA1 H2AZ1 H2AZ1 SAP130 SAP130 POLR2F POLR2F SIN3A SIN3A ENSMFAP00000006991 ENSMFAP00000006991 GTF2H2 GTF2H2 SIN3B SIN3B ENSMFAP00000043336 ENSMFAP00000043336 H2BC15 H2BC15 ENSMFAP00000042423 ENSMFAP00000042423 TTF1 TTF1 ZNRD1 ZNRD1 UBTF UBTF POLR1C POLR1C SIRT1 SIRT1 POLR1A POLR1A RRP8 RRP8 ERCC2 ERCC2 POLR2H POLR2H GTF2H3 GTF2H3 SAP30 SAP30 ENSMFAP00000034298 ENSMFAP00000034298 ERCC3 ERCC3 TAF1C TAF1C POLR2E POLR2E GTF2H5 GTF2H5 SUV39H1 SUV39H1 POLR1E POLR1E TWISTNB TWISTNB H3F3A H3F3A ENSMFAP00000025317 ENSMFAP00000025317 ARID4B ARID4B SMARCA5 SMARCA5 ENSMFAP00000022290 ENSMFAP00000022290 H3F3B H3F3B LOC102128824 LOC102128824 GTF2H1 GTF2H1 POLR1B POLR1B ENSMFAP00000018013 ENSMFAP00000018013 TBP TBP SUDS3 SUDS3 ENSMFAP00000015493 ENSMFAP00000015493 POLR2K POLR2K ENSMFAP00000015196 ENSMFAP00000015196 ENSMFAP00000015138 ENSMFAP00000015138 ENSMFAP00000015119 ENSMFAP00000015119 ENSMFAP00000015112 ENSMFAP00000015112 ENSMFAP00000015065 ENSMFAP00000015065 ENSMFAP00000015048 ENSMFAP00000015048 MBD2 MBD2 ENSMFAP00000014826 ENSMFAP00000014826 ENSMFAP00000014776 ENSMFAP00000014776 ENSMFAP00000014622 ENSMFAP00000014622 ENSMFAP00000014529 ENSMFAP00000014529 BAZ2A BAZ2A G8F5U3_MACFA G8F5U3_MACFA HIST2H2BE HIST2H2BE H2BC3 H2BC3 ENSMFAP00000013484 ENSMFAP00000013484
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102146894Histone domain-containing protein. (136 aa)
G8F2Z2_MACFAHistone H2B; Belongs to the histone H2B family. (126 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1632 aa)
ENSMFAP00000012784annotation not available (136 aa)
ENSMFAP00000012416annotation not available (136 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMFAP00000012162Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000012034Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102130997Histone H3; Belongs to the histone H3 family. (136 aa)
H3C1H3 clustered histone 1. (136 aa)
H2AJHistone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (129 aa)
ENSMFAP00000011563annotation not available (136 aa)
ENSMFAP00000011394annotation not available (126 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
G7P2P1_MACFAHistone H2B; Belongs to the histone H2B family. (126 aa)
ENSMFAP00000011138Histone H4. (103 aa)
ENSMFAP00000010884Histone H4. (103 aa)
ENSMFAP00000010867Histone H4. (103 aa)
ENSMFAP00000010848Histone H4. (103 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
CCNHCyclin-H; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout t [...] (325 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
ENSMFAP00000010686Histone H4. (103 aa)
H2BC11Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
ENSMFAP00000010627Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000010517Histone H4. (103 aa)
CD3EAPCD3e molecule associated protein. (513 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSMFAP00000010040Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
ENSMFAP00000010034annotation not available (136 aa)
ENSMFAP00000010006annotation not available (136 aa)
SAP18Uncharacterized protein. (172 aa)
ENSMFAP00000009974Histone H4. (103 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H2BOHistone H2B; Belongs to the histone H2B family. (126 aa)
LOC102147067Histone H3; Belongs to the histone H3 family. (136 aa)
HIST1H3BHistone H3; Belongs to the histone H3 family. (136 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ENSMFAP00000008526Histone H2A; Belongs to the histone H2A family. (106 aa)
SAP30BPSAP30 binding protein. (308 aa)
SAP30LSAP30 like. (184 aa)
DNMT3BDNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (853 aa)
TAF1AUncharacterized protein. (451 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
TAF1DTATA-box binding protein associated factor, RNA polymerase I subunit D. (278 aa)
BAZ2BBromodomain adjacent to zinc finger domain 2B. (2169 aa)
ENSMFAP00000043498Uncharacterized protein. (69 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ENSMFAP00000001505Histone H2A; Belongs to the histone H2A family. (126 aa)
LOC102121517Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (103 aa)
LOC102138275Histone H4. (103 aa)
ENSMFAP00000002027Histone H2A; Belongs to the histone H2A family. (117 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
ENSMFAP00000004828Uncharacterized protein. (67 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1110 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
SAP130Sin3A associated protein 130. (1083 aa)
POLR2FRNA polymerase II subunit F. (158 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
ENSMFAP00000006991Histone H2B; Belongs to the histone H2B family. (149 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
SIN3BSIN3 transcription regulator family member B. (1159 aa)
ENSMFAP00000043336Histone H2B; Belongs to the histone H2B family. (129 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (165 aa)
ENSMFAP00000042423Protein kinase domain-containing protein. (140 aa)
TTF1Transcription termination factor 1. (916 aa)
ZNRD1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
UBTFUpstream binding transcription factor. (764 aa)
POLR1CRNA polymerase I and III subunit C. (350 aa)
SIRT1Sirtuin 1. (743 aa)
POLR1ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1720 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (768 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
GTF2H3Uncharacterized protein. (172 aa)
SAP30Sin3A associated protein 30. (220 aa)
ENSMFAP00000034298Histone H3; Belongs to the histone H3 family. (141 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (786 aa)
TAF1CTATA-box binding protein associated factor, RNA polymerase I subunit C. (843 aa)
POLR2EUncharacterized protein. (210 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (423 aa)
POLR1ERNA polymerase I subunit E. (484 aa)
TWISTNBTWIST neighbor. (338 aa)
H3F3Aannotation not available (136 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
ARID4BAT-rich interaction domain 4B. (1314 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
ENSMFAP00000022290Histone domain-containing protein. (113 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
LOC102128824Uncharacterized protein. (134 aa)
GTF2H1Uncharacterized protein. (548 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
ENSMFAP00000018013Uncharacterized protein. (443 aa)
TBPTATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase [...] (326 aa)
SUDS3SDS3 homolog, SIN3A corepressor complex component. (328 aa)
ENSMFAP00000015493Uncharacterized protein. (235 aa)
POLR2KUncharacterized protein. (58 aa)
ENSMFAP00000015196Histone H4. (103 aa)
ENSMFAP00000015138Histone H4. (103 aa)
ENSMFAP00000015119Histone H4. (103 aa)
ENSMFAP00000015112annotation not available (126 aa)
ENSMFAP00000015065Histone H4. (103 aa)
ENSMFAP00000015048annotation not available (136 aa)
MBD2Methyl-CpG binding domain protein 2. (370 aa)
ENSMFAP00000014826annotation not available (136 aa)
ENSMFAP00000014776annotation not available (136 aa)
ENSMFAP00000014622Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMFAP00000014529Uncharacterized protein. (106 aa)
BAZ2ABromodomain adjacent to zinc finger domain 2A. (1910 aa)
G8F5U3_MACFAHistone H3; Belongs to the histone H3 family. (136 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMFAP00000013484Histone H4. (103 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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