STRINGSTRING
REV3L REV3L ENSMFAP00000004513 ENSMFAP00000004513 ENSMFAP00000005841 ENSMFAP00000005841 ENSMFAP00000007027 ENSMFAP00000007027 ATAD5 ATAD5 RPA1 RPA1 ENSMFAP00000009883 ENSMFAP00000009883 UBC UBC LOC101864869 LOC101864869 ENSMFAP00000011880 ENSMFAP00000011880 ENSMFAP00000012290 ENSMFAP00000012290 LOC102117118 LOC102117118 RFC4 RFC4 ENSMFAP00000015231 ENSMFAP00000015231 ENSMFAP00000015936 ENSMFAP00000015936 POLK POLK REV1 REV1 RFC5 RFC5 KXD1 KXD1 RCBTB1 RCBTB1 RFC3 RFC3 RFC1 RFC1 RPA3 RPA3 RCBTB2 RCBTB2 PCNA PCNA RPS27A RPS27A RFC2 RFC2 MAD2L2 MAD2L2 UBB UBB ENSMFAP00000044257 ENSMFAP00000044257 MEIOB MEIOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3127 aa)
ENSMFAP00000004513Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
ENSMFAP00000005841Ubiquitin-like domain-containing protein. (122 aa)
ENSMFAP00000007027Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (506 aa)
ATAD5ATPase family AAA domain containing 5. (1820 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (267 aa)
ENSMFAP00000009883Ubiquitin-like domain-containing protein. (147 aa)
UBCUbiquitin C. (645 aa)
LOC101864869Ubiquitin-like domain-containing protein. (156 aa)
ENSMFAP00000011880Ubiquitin-like domain-containing protein. (128 aa)
ENSMFAP00000012290Ubiquitin-like domain-containing protein. (156 aa)
LOC102117118Ubiquitin-like domain-containing protein. (127 aa)
RFC4Replication factor C subunit 4. (363 aa)
ENSMFAP00000015231Uncharacterized protein. (118 aa)
ENSMFAP00000015936Ubiquitin-like domain-containing protein. (144 aa)
POLKDNA polymerase kappa. (870 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1250 aa)
RFC5Replication factor C subunit 5. (343 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RFC3Replication factor C subunit 3/5. (356 aa)
RFC1Replication factor C subunit 1. (1148 aa)
RPA3Uncharacterized protein. (121 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
PCNAProliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa)
RPS27ABrain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa)
RFC2Replication factor C subunit 2. (352 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
UBBUncharacterized protein. (219 aa)
ENSMFAP00000044257Uncharacterized protein. (83 aa)
MEIOBMeiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] (471 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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