STRINGSTRING
GTF2H3 GTF2H3 POLD3 POLD3 ERCC1 ERCC1 XPA XPA ENSMFAP00000004513 ENSMFAP00000004513 BIVM BIVM PARP1 PARP1 ENSMFAP00000005841 ENSMFAP00000005841 POLE2 POLE2 ENSMFAP00000007027 ENSMFAP00000007027 ENSMFAP00000007997 ENSMFAP00000007997 GTF2H2 GTF2H2 RPA1 RPA1 ENSMFAP00000009883 ENSMFAP00000009883 POLD1 POLD1 RPA3 RPA3 DDB1 DDB1 CUL4B CUL4B POLD2 POLD2 RCBTB2 RCBTB2 PCNA PCNA GTF2H5 GTF2H5 ERCC3 ERCC3 RPS27A RPS27A ERCC2 ERCC2 POLE4 POLE4 RFC2 RFC2 POLD4 POLD4 UBB UBB RBX1 RBX1 POLE POLE ENSMFAP00000044257 ENSMFAP00000044257 ENSMFAP00000045746 ENSMFAP00000045746 UBC UBC LOC101864869 LOC101864869 PARP2 PARP2 ENSMFAP00000011880 ENSMFAP00000011880 ENSMFAP00000012290 ENSMFAP00000012290 GTF2H4 GTF2H4 LOC102117118 LOC102117118 RFC4 RFC4 POLE3 POLE3 ENSMFAP00000015231 ENSMFAP00000015231 ENSMFAP00000015936 ENSMFAP00000015936 DDB2 DDB2 ENSMFAP00000018013 ENSMFAP00000018013 PARP3 PARP3 ENSMFAP00000020112 ENSMFAP00000020112 GTF2H1 GTF2H1 LOC102128824 LOC102128824 ERCC4 ERCC4 POLK POLK CHD1L CHD1L RFC1 RFC1 RFC3 RFC3 RCBTB1 RCBTB1 KXD1 KXD1 RFC5 RFC5 CUL4A CUL4A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GTF2H3Uncharacterized protein. (172 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
ENSMFAP00000004513Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
BIVMBIVM-ERCC5 readthrough. (1638 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
ENSMFAP00000005841Ubiquitin-like domain-containing protein. (122 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (533 aa)
ENSMFAP00000007027Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (506 aa)
ENSMFAP00000007997DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (189 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (267 aa)
ENSMFAP00000009883Ubiquitin-like domain-containing protein. (147 aa)
POLD1DNA polymerase. (1107 aa)
RPA3Uncharacterized protein. (121 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
CUL4BCullin 4B; Belongs to the cullin family. (913 aa)
POLD2Uncharacterized protein. (504 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
PCNAProliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (786 aa)
RPS27ABrain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (768 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
RFC2Replication factor C subunit 2. (352 aa)
POLD4Uncharacterized protein. (107 aa)
UBBUncharacterized protein. (219 aa)
RBX1RING-box protein 1. (108 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (370 aa)
ENSMFAP00000044257Uncharacterized protein. (83 aa)
ENSMFAP00000045746Zf-rbx1 domain-containing protein. (93 aa)
UBCUbiquitin C. (645 aa)
LOC101864869Ubiquitin-like domain-containing protein. (156 aa)
PARP2Poly [ADP-ribose] polymerase. (570 aa)
ENSMFAP00000011880Ubiquitin-like domain-containing protein. (128 aa)
ENSMFAP00000012290Ubiquitin-like domain-containing protein. (156 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
LOC102117118Ubiquitin-like domain-containing protein. (127 aa)
RFC4Replication factor C subunit 4. (363 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
ENSMFAP00000015231Uncharacterized protein. (118 aa)
ENSMFAP00000015936Ubiquitin-like domain-containing protein. (144 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
ENSMFAP00000018013Uncharacterized protein. (443 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
ENSMFAP00000020112Uncharacterized protein. (57 aa)
GTF2H1Uncharacterized protein. (548 aa)
LOC102128824Uncharacterized protein. (134 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
POLKDNA polymerase kappa. (870 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (878 aa)
RFC1Replication factor C subunit 1. (1148 aa)
RFC3Replication factor C subunit 3/5. (356 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa)
RFC5Replication factor C subunit 5. (343 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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