105 items (Macaca fascicularis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DBNL	Uncharacterized protein. (419 aa)
	APBA2	Amyloid beta precursor protein binding family A member 2. (749 aa)
	ENSMFAP00000001834	COesterase domain-containing protein. (221 aa)
	SLITRK1	SLIT and NTRK like family member 1. (696 aa)
	SLITRK6	SLIT and NTRK like family member 6. (841 aa)
	SLITRK5	SLIT and NTRK like family member 5. (958 aa)
	ENSMFAP00000002311	Uncharacterized protein. (150 aa)
	ENSMFAP00000002463	Uncharacterized protein. (226 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
	SYT2	Synaptotagmin 2. (419 aa)
	HOMER1	Homer scaffold protein 1. (358 aa)
	LRRTM4	Leucine rich repeat transmembrane neuronal 4. (591 aa)
	GRIA4	Glutamate receptor 4; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] (902 aa)
	LRRTM3	Leucine-rich repeat transmembrane neuronal protein 3; May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity); Belongs to the LRRTM family. (581 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	ENSMFAP00000005493	COesterase domain-containing protein. (295 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)
	IL1RAPL2	Interleukin 1 receptor accessory protein like 2. (686 aa)
	PPFIA4	PTPRF interacting protein alpha 4. (1252 aa)
	GRM1	Glutamate metabotropic receptor 1. (1195 aa)
	LRFN1	Leucine rich repeat and fibronectin type III domain containing 1. (767 aa)
	PTPRS	Protein tyrosine phosphatase receptor type S. (1948 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
	PPFIA3	PTPRF interacting protein alpha 3. (1194 aa)
	GRIA3	Glutamate receptor 3; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] (894 aa)
	PAPLN	Papilin, proteoglycan like sulfated glycoprotein. (1271 aa)
	LRRTM1	Leucine rich repeat transmembrane neuronal 1. (522 aa)
	VASN	Vasorin. (673 aa)
	EPB41L2	Erythrocyte membrane protein band 4.1 like 2. (998 aa)
	SH3GLB2	SH3 domain containing GRB2 like, endophilin B2. (404 aa)
	SLITRK4	SLIT and NTRK like family member 4. (837 aa)
	SLITRK3	SLIT and NTRK like family member 3. (979 aa)
	SLITRK2	SLIT and NTRK like family member 2. (845 aa)
	RTN3	Reticulon. (1027 aa)
	LRRC4C	Leucine rich repeat containing 4C. (640 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
	TJAP1	Tight junction associated protein 1. (541 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (2171 aa)
	ANKRD53	Ankyrin repeat domain-containing protein 53; Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization. (530 aa)
	NRXN3	Neurexin 3. (1664 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (840 aa)
	HOMER3	WH1 domain-containing protein. (361 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1742 aa)
	DLGAP1	DLG associated protein 1. (917 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1062 aa)
	PPFIA2	PTPRF interacting protein alpha 2. (1257 aa)
	CHAD	Chondroadherin. (359 aa)
	PTPRD	Protein tyrosine phosphatase receptor type D. (1912 aa)
	DLGAP4	DLG associated protein 4. (992 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
	BEGAIN	Brain enriched guanylate kinase associated. (812 aa)
	EPB41L3	Erythrocyte membrane protein band 4.1 like 3. (1087 aa)
	PPFIA1	PTPRF interacting protein alpha 1. (1267 aa)
	UFC1	Uncharacterized protein. (154 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
	GRIA1	Glutamate receptor 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulati [...] (916 aa)
	SYT7	Synaptotagmin 7. (686 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (975 aa)
	LRFN3	Leucine rich repeat and fibronectin type III domain containing 3. (628 aa)
	APBA3	Amyloid beta precursor protein binding family A member 3. (575 aa)
	NTRK3	NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. (866 aa)
	ENSMFAP00000025899	Uncharacterized protein. (316 aa)
	SH3GLB1	SH3 domain containing GRB2 like, endophilin B1. (402 aa)
	HOMER2	Homer scaffold protein 2. (360 aa)
	LRFN4	Leucine rich repeat and fibronectin type III domain containing 4. (635 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1596 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (733 aa)
	EPB41L4A	Erythrocyte membrane protein band 4.1 like 4A. (659 aa)
	IL1RAP	Interleukin 1 receptor accessory protein. (687 aa)
	LRRTM2	Leucine rich repeat transmembrane neuronal 2. (516 aa)
	ENSMFAP00000044418	Uncharacterized protein. (392 aa)
	EPB41L1	Erythrocyte membrane protein band 4.1 like 1. (889 aa)
	DLGAP2	DLG associated protein 2. (1053 aa)
	LIN7A	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
	LRRC4	Leucine rich repeat containing 4. (633 aa)
	PPFIBP2	PPFIA binding protein 2. (926 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (483 aa)
	EPB41L4B	Erythrocyte membrane protein band 4.1 like 4B. (831 aa)
	DLG3	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (863 aa)
	EPB41	Erythrocyte membrane protein band 4.1. (865 aa)
	SYT6	Synaptotagmin 6. (548 aa)
	IL1RAPL1	Interleukin 1 receptor accessory protein like 1. (696 aa)
	LIN7B	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
	SHARPIN	SHANK associated RH domain interactor. (381 aa)
	NRXN1	Neurexin 1. (1507 aa)
	DLGAP3	DLG associated protein 3. (979 aa)
	SYT9	Synaptotagmin 9. (491 aa)
	SIPA1L1	Signal induced proliferation associated 1 like 1. (1804 aa)
	NLGN4Y	Neuroligin 4 Y-linked. (873 aa)
	SYT10	Synaptotagmin 10. (523 aa)
	STXBP1	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (625 aa)
	GRM5	Glutamate metabotropic receptor 5. (1212 aa)
	SYT1	Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...] (422 aa)
	NRXN2	Neurexin 2. (1713 aa)
	PTPRF	Protein tyrosine phosphatase receptor type F. (1909 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
	LRRC4B	Leucine rich repeat containing 4B. (715 aa)
	PPFIBP1	PPFIA binding protein 1. (1025 aa)
	NLGN1	Neuroligin 1. (823 aa)
	NLGN2	Neuroligin 2. (849 aa)
	SYT12	Synaptotagmin 12. (421 aa)
	LRFN2	Leucine-rich repeat and fibronectin type-III domain-containing protein 2; Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity). (808 aa)
	LIN7C	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1242 aa)
	SYT3	Synaptotagmin 3. (590 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA1	CASK	ENSMFAP00000016512	ENSMFAP00000022644	Amyloid beta precursor protein binding family A member 1.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.995
APBA1	DLG1	ENSMFAP00000016512	ENSMFAP00000002487	Amyloid beta precursor protein binding family A member 1.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.413
APBA1	DLG2	ENSMFAP00000016512	ENSMFAP00000024144	Amyloid beta precursor protein binding family A member 1.	Discs large MAGUK scaffold protein 2.	0.413
APBA1	DLG4	ENSMFAP00000016512	ENSMFAP00000018582	Amyloid beta precursor protein binding family A member 1.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.406
APBA1	GRIN2B	ENSMFAP00000016512	ENSMFAP00000010343	Amyloid beta precursor protein binding family A member 1.	Glutamate ionotropic receptor NMDA type subunit 2B.	0.454
APBA1	LIN7A	ENSMFAP00000016512	ENSMFAP00000042837	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.812
APBA1	LIN7B	ENSMFAP00000016512	ENSMFAP00000039522	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.725
APBA1	LIN7C	ENSMFAP00000016512	ENSMFAP00000028432	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.798
APBA1	NRXN1	ENSMFAP00000016512	ENSMFAP00000038691	Amyloid beta precursor protein binding family A member 1.	Neurexin 1.	0.494
APBA1	PPFIA1	ENSMFAP00000016512	ENSMFAP00000020303	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 1.	0.482
APBA1	PPFIA2	ENSMFAP00000016512	ENSMFAP00000017259	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 2.	0.448
APBA1	PPFIA3	ENSMFAP00000016512	ENSMFAP00000010638	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 3.	0.518
APBA1	PPFIA4	ENSMFAP00000016512	ENSMFAP00000007461	Amyloid beta precursor protein binding family A member 1.	PTPRF interacting protein alpha 4.	0.408
APBA1	STX1A	ENSMFAP00000016512	ENSMFAP00000007349	Amyloid beta precursor protein binding family A member 1.	Syntaxin 1A; Belongs to the syntaxin family.	0.774
APBA1	STXBP1	ENSMFAP00000016512	ENSMFAP00000036383	Amyloid beta precursor protein binding family A member 1.	Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family.	0.953
APBA1	SYT1	ENSMFAP00000016512	ENSMFAP00000034025	Amyloid beta precursor protein binding family A member 1.	Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...]	0.458
APBA1	SYT2	ENSMFAP00000016512	ENSMFAP00000003025	Amyloid beta precursor protein binding family A member 1.	Synaptotagmin 2.	0.412
APBA2	CASK	ENSMFAP00000000020	ENSMFAP00000022644	Amyloid beta precursor protein binding family A member 2.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.993
APBA2	LIN7A	ENSMFAP00000000020	ENSMFAP00000042837	Amyloid beta precursor protein binding family A member 2.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.564
APBA2	LIN7B	ENSMFAP00000000020	ENSMFAP00000039522	Amyloid beta precursor protein binding family A member 2.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.564

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