STRINGSTRING
ING1 ING1 ENSMFAP00000025317 ENSMFAP00000025317 MBD3 MBD3 PIP4P2 PIP4P2 ENSMFAP00000027449 ENSMFAP00000027449 ENSMFAP00000026376 ENSMFAP00000026376 BRPF1 BRPF1 KAT6A KAT6A PIP4P1 PIP4P1 RBBP4 RBBP4 ENSMFAP00000043974 ENSMFAP00000043974 ENSMFAP00000044019 ENSMFAP00000044019 ENSMFAP00000044114 ENSMFAP00000044114 EP300 EP300 PIN1 PIN1 BRPF3 BRPF3 ENSMFAP00000042484 ENSMFAP00000042484 PIP4K2C PIP4K2C MAP2K6 MAP2K6 TP53 TP53 RBBP7 RBBP7 CHD5 CHD5 CHD4 CHD4 AKT2 AKT2 PIP4K2A PIP4K2A ENSMFAP00000033106 ENSMFAP00000033106 GATAD2B GATAD2B MTA2 MTA2 HDAC2 HDAC2 FOXP4 FOXP4 ENSMFAP00000000647 ENSMFAP00000000647 ENSMFAP00000001828 ENSMFAP00000001828 BRD9 BRD9 MEAF6 MEAF6 AIRE AIRE LOC101925812 LOC101925812 PML PML PIP4K2B PIP4K2B HDAC1 HDAC1 LOC102139770 LOC102139770 ENSMFAP00000010148 ENSMFAP00000010148 CHD3 CHD3 BRD1 BRD1 AKT1 AKT1 ING2 ING2 AKT3 AKT3 ING5 ING5 BRD7 BRD7 ENSMFAP00000024220 ENSMFAP00000024220
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ING1Inhibitor of growth protein. (417 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
MBD3Methyl-CpG binding domain protein 3. (291 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
ENSMFAP00000027449WD_REPEATS_REGION domain-containing protein. (261 aa)
ENSMFAP00000026376WD_REPEATS_REGION domain-containing protein. (381 aa)
BRPF1Bromodomain and PHD finger containing 1. (1248 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa)
PIP4P1Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrog [...] (277 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (425 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
ENSMFAP00000044019WD_REPEATS_REGION domain-containing protein. (237 aa)
ENSMFAP00000044114Uncharacterized protein. (114 aa)
EP300E1A binding protein p300. (2414 aa)
PIN1Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis- promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple [...] (145 aa)
BRPF3Bromodomain and PHD finger containing 3. (1205 aa)
ENSMFAP00000042484CAF1C_H4-bd domain-containing protein. (69 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
RBBP7Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and [...] (469 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1983 aa)
CHD4Uncharacterized protein. (1912 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
ENSMFAP00000033106P66_CC domain-containing protein. (155 aa)
GATAD2BGATA zinc finger domain containing 2B. (564 aa)
MTA2Metastasis associated 1 family member 2. (673 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
FOXP4Forkhead box P4. (679 aa)
ENSMFAP00000000647WD_REPEATS_REGION domain-containing protein. (410 aa)
ENSMFAP00000001828CAF1C_H4-bd domain-containing protein. (103 aa)
BRD9Bromodomain containing 9. (529 aa)
MEAF6MYST/Esa1 associated factor 6. (201 aa)
AIREAutoimmune regulator. (579 aa)
LOC101925812GATA-type domain-containing protein. (555 aa)
PMLPromyelocytic leukemia. (882 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
LOC102139770GATA-type domain-containing protein. (428 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2000 aa)
BRD1Bromodomain containing 1. (1189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ING2Inhibitor of growth protein. (280 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ING5Inhibitor of growth family member 5. (252 aa)
BRD7Bromodomain containing 7. (652 aa)
ENSMFAP00000024220WD_REPEATS_REGION domain-containing protein. (398 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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