STRINGSTRING
DMTF1 DMTF1 POLR2L POLR2L AIRE AIRE CDK7 CDK7 ENSMFAP00000001828 ENSMFAP00000001828 KAT2A KAT2A ENSMFAP00000000647 ENSMFAP00000000647 HDAC2 HDAC2 LOC101925812 LOC101925812 TAF1D TAF1D ENSMFAP00000043498 ENSMFAP00000043498 ENSMFAP00000042484 ENSMFAP00000042484 ENSMFAP00000042423 ENSMFAP00000042423 ENSMFAP00000043974 ENSMFAP00000043974 TAF1A TAF1A ENSMFAP00000044019 ENSMFAP00000044019 ENSMFAP00000044114 ENSMFAP00000044114 TTF1 TTF1 ZNRD1 ZNRD1 UBTF UBTF TAF1B TAF1B POLR1C POLR1C GCNA GCNA POLR1A POLR1A ERCC2 ERCC2 POLR2H POLR2H GTF2H3 GTF2H3 MTA3 MTA3 RBBP7 RBBP7 CHD5 CHD5 CHD4 CHD4 ERCC3 ERCC3 TAF1C TAF1C ENSMFAP00000033106 ENSMFAP00000033106 POLR2E POLR2E GTF2H5 GTF2H5 UBN2 UBN2 GATAD2B GATAD2B MTA2 MTA2 POLR1E POLR1E TWISTNB TWISTNB ENSMFAP00000027449 ENSMFAP00000027449 ENSMFAP00000026376 ENSMFAP00000026376 MBD3 MBD3 ENSMFAP00000025317 ENSMFAP00000025317 ENSMFAP00000024220 ENSMFAP00000024220 KAT2B KAT2B LOC102128824 LOC102128824 ERCC6 ERCC6 GTF2H1 GTF2H1 POLR1B POLR1B EHMT2 EHMT2 ENSMFAP00000018013 ENSMFAP00000018013 MTA1 MTA1 TBP TBP POLR2K POLR2K CHD3 CHD3 GTF2H4 GTF2H4 CCNH CCNH CD3EAP CD3EAP ENSMFAP00000010148 ENSMFAP00000010148 LOC102139770 LOC102139770 MNAT1 MNAT1 HDAC1 HDAC1 GTF2H2 GTF2H2 RRN3 RRN3 POLR2F POLR2F RBBP4 RBBP4 ENSMFAP00000004828 ENSMFAP00000004828
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DMTF1Cyclin D binding myb like transcription factor 1. (761 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
AIREAutoimmune regulator. (579 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
ENSMFAP00000001828CAF1C_H4-bd domain-containing protein. (103 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
ENSMFAP00000000647WD_REPEATS_REGION domain-containing protein. (410 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
LOC101925812GATA-type domain-containing protein. (555 aa)
TAF1DTATA-box binding protein associated factor, RNA polymerase I subunit D. (278 aa)
ENSMFAP00000043498Uncharacterized protein. (69 aa)
ENSMFAP00000042484CAF1C_H4-bd domain-containing protein. (69 aa)
ENSMFAP00000042423Protein kinase domain-containing protein. (140 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
TAF1AUncharacterized protein. (451 aa)
ENSMFAP00000044019WD_REPEATS_REGION domain-containing protein. (237 aa)
ENSMFAP00000044114Uncharacterized protein. (114 aa)
TTF1Transcription termination factor 1. (916 aa)
ZNRD1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
UBTFUpstream binding transcription factor. (764 aa)
TAF1BTATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 (By similarity). Belongs to the RRN7/TAF1B family. (588 aa)
POLR1CRNA polymerase I and III subunit C. (350 aa)
GCNAGerm cell nuclear acidic peptidase. (682 aa)
POLR1ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1720 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (768 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
GTF2H3Uncharacterized protein. (172 aa)
MTA3Metastasis associated 1 family member 3. (593 aa)
RBBP7Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and [...] (469 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1983 aa)
CHD4Uncharacterized protein. (1912 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (786 aa)
TAF1CTATA-box binding protein associated factor, RNA polymerase I subunit C. (843 aa)
ENSMFAP00000033106P66_CC domain-containing protein. (155 aa)
POLR2EUncharacterized protein. (210 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
UBN2Ubinuclein 2. (1326 aa)
GATAD2BGATA zinc finger domain containing 2B. (564 aa)
MTA2Metastasis associated 1 family member 2. (673 aa)
POLR1ERNA polymerase I subunit E. (484 aa)
TWISTNBTWIST neighbor. (338 aa)
ENSMFAP00000027449WD_REPEATS_REGION domain-containing protein. (261 aa)
ENSMFAP00000026376WD_REPEATS_REGION domain-containing protein. (381 aa)
MBD3Methyl-CpG binding domain protein 3. (291 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
ENSMFAP00000024220WD_REPEATS_REGION domain-containing protein. (398 aa)
KAT2BLysine acetyltransferase 2B. (731 aa)
LOC102128824Uncharacterized protein. (134 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1496 aa)
GTF2H1Uncharacterized protein. (548 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1266 aa)
ENSMFAP00000018013Uncharacterized protein. (443 aa)
MTA1Metastasis associated 1. (726 aa)
TBPTATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase [...] (326 aa)
POLR2KUncharacterized protein. (58 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2000 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
CCNHCyclin-H; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout t [...] (325 aa)
CD3EAPCD3e molecule associated protein. (513 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
LOC102139770GATA-type domain-containing protein. (428 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
RRN3RRN3 homolog, RNA polymerase I transcription factor. (651 aa)
POLR2FRNA polymerase II subunit F. (158 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (425 aa)
ENSMFAP00000004828Uncharacterized protein. (67 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.