STRINGSTRING
ENSMFAP00000038331 ENSMFAP00000038331 TNFRSF10B TNFRSF10B TNFSF10 TNFSF10 TIAM1 TIAM1 SMPD3 SMPD3 FGD3 FGD3 HDAC3 HDAC3 ENSMFAP00000005841 ENSMFAP00000005841 ARHGEF4 ARHGEF4 NFATC4 NFATC4 ULK2 ULK2 PSENEN PSENEN SOS2 SOS2 USP2 USP2 APH1A APH1A TGM3 TGM3 MAP3K20 MAP3K20 HDAC1 HDAC1 ARHGEF9 ARHGEF9 MADD MADD TIAM2 TIAM2 FGD1 FGD1 ENSMFAP00000009883 ENSMFAP00000009883 ENSMFAP00000010148 ENSMFAP00000010148 ARHGEF2 ARHGEF2 UBC UBC LOC101864869 LOC101864869 LINGO1 LINGO1 SESTD1 SESTD1 ARHGEF10 ARHGEF10 NFKBIA NFKBIA LOC102140123 LOC102140123 ENSMFAP00000011880 ENSMFAP00000011880 RIPK2 RIPK2 TNFRSF10A TNFRSF10A ENSMFAP00000012290 ENSMFAP00000012290 ENSMFAP00000012453 ENSMFAP00000012453 ARHGEF40 ARHGEF40 ENSMFAP00000013287 ENSMFAP00000013287 TGM6 TGM6 LINGO2 LINGO2 OMG OMG LOC102117118 LOC102117118 TNFRSF10D TNFRSF10D ENSMFAP00000013814 ENSMFAP00000013814 ARHGEF3 ARHGEF3 ENSMFAP00000013942 ENSMFAP00000013942 ENSMFAP00000015310 ENSMFAP00000015310 ARHGEF26 ARHGEF26 VAV3 VAV3 FGD2 FGD2 MCF2L MCF2L ENSMFAP00000015936 ENSMFAP00000015936 TRAF1 TRAF1 AKAP13 AKAP13 ENSMFAP00000016852 ENSMFAP00000016852 NGEF NGEF CASP10 CASP10 SOS1 SOS1 OBSCN OBSCN TBK1 TBK1 FGD4 FGD4 BAG4 BAG4 IKBKG IKBKG TAB1 TAB1 ARHGEF1 ARHGEF1 OTUD1 OTUD1 TRADD TRADD SQSTM1 SQSTM1 BIRC2 BIRC2 SMPD2 SMPD2 TRAF2 TRAF2 FAS FAS RELA RELA MAPKAPK2 MAPKAPK2 BAD BAD TRIO TRIO PLEKHG5 PLEKHG5 ENSMFAP00000023078 ENSMFAP00000023078 RACK1 RACK1 USP4 USP4 CYLD CYLD BIRC3 BIRC3 ARHGEF5 ARHGEF5 MAG MAG KALRN KALRN NGFR NGFR ITSN1 ITSN1 CLIP3 CLIP3 ENSMFAP00000025317 ENSMFAP00000025317 CLIP4 CLIP4 ABR ABR ENSMFAP00000026546 ENSMFAP00000026546 KXD1 KXD1 UBE2D1 UBE2D1 BIRC7 BIRC7 PLEKHG2 PLEKHG2 OPTN OPTN FADD FADD MYD88 MYD88 ARHGEF15 ARHGEF15 PRDM4 PRDM4 ULK1 ULK1 RBCK1 RBCK1 STUB1 STUB1 CASP2 CASP2 TNFRSF1A TNFRSF1A CFLAR CFLAR ENSMFAP00000030877 ENSMFAP00000030877 IKBKE IKBKE TAB3 TAB3 USP21 USP21 TAB2 TAB2 CASP3 CASP3 SPPL2A SPPL2A RIPK1 RIPK1 ENSMFAP00000032874 ENSMFAP00000032874 RTN4R RTN4R ARHGEF7 ARHGEF7 RTN4 RTN4 RASGRF2 RASGRF2 AATF AATF UBE2D3 UBE2D3 BEX3 BEX3 MCF2 MCF2 NCSTN NCSTN NSMAF NSMAF UBE2D2 UBE2D2 VAV2 VAV2 NGF NGF ENSMFAP00000035756 ENSMFAP00000035756 CASP8 CASP8 OTULINL OTULINL ARHGEF18 ARHGEF18 OTULIN OTULIN RPS27A RPS27A MAPK8 MAPK8 ARHGEF11 ARHGEF11 PRKCI PRKCI WDR31 WDR31 NET1 NET1 SHARPIN SHARPIN MAP3K7 MAP3K7 ARHGEF39 ARHGEF39 ARHGEF16 ARHGEF16 SPATA2 SPATA2 ARHGEF6 ARHGEF6 ENSMFAP00000040719 ENSMFAP00000040719 ARHGEF38 ARHGEF38 UBB UBB ECT2 ECT2 ARHGEF33 ARHGEF33 YWHAE YWHAE MAGED1 MAGED1 IKBKB IKBKB VAV1 VAV1 SPPL2B SPPL2B TRAF6 TRAF6 ITGB3BP ITGB3BP ARHGEF10L ARHGEF10L XIAP XIAP RNF31 RNF31 TAX1BP1 TAX1BP1 BCL2L11 BCL2L11 ADAM17 ADAM17 FASLG FASLG NAIP NAIP ENSMFAP00000043974 ENSMFAP00000043974 ARHGEF19 ARHGEF19 UBE2D4 UBE2D4 APH1B APH1B TNFAIP3 TNFAIP3 PREX1 PREX1 CHUK CHUK HDAC2 HDAC2 ARHGEF17 ARHGEF17 TMEM198 TMEM198 UBE2L5 UBE2L5 MCF2L2 MCF2L2 NFKB1 NFKB1 IRAK1 IRAK1 PSEN1 PSEN1 RHOA RHOA LOC102122430 LOC102122430 PSEN2 PSEN2 ENSMFAP00000002560 ENSMFAP00000002560 ARHGEF37 ARHGEF37 TNF TNF ECT2L ECT2L OTUD7B OTUD7B MIB2 MIB2 ARHGEF12 ARHGEF12 ENSMFAP00000003736 ENSMFAP00000003736 MAPK10 MAPK10 GNA13 GNA13
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMFAP00000038331UBIQUITIN_CONJUGAT_2 domain-containing protein. (119 aa)
TNFRSF10BTNF receptor superfamily member 10b. (445 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (737 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
ENSMFAP00000005841Ubiquitin-like domain-containing protein. (122 aa)
ARHGEF4Uncharacterized protein. (1864 aa)
NFATC4Nuclear factor of activated T cells 4. (918 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1036 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa)
APH1AUncharacterized protein. (265 aa)
TGM3TGc domain-containing protein. (836 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ARHGEF9Cdc42 guanine nucleotide exchange factor 9. (552 aa)
MADDMAP kinase activating death domain. (1635 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1725 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (961 aa)
ENSMFAP00000009883Ubiquitin-like domain-containing protein. (147 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
UBCUbiquitin C. (645 aa)
LOC101864869Ubiquitin-like domain-containing protein. (156 aa)
LINGO1Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). (620 aa)
SESTD1SEC14 and spectrin domain containing 1. (696 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1049 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
LOC102140123Ubiquitin-conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ENSMFAP00000011880Ubiquitin-like domain-containing protein. (128 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
TNFRSF10ATNF receptor superfamily member 10a. (311 aa)
ENSMFAP00000012290Ubiquitin-like domain-containing protein. (156 aa)
ENSMFAP00000012453Hist_deacetyl domain-containing protein. (223 aa)
ARHGEF40Rho guanine nucleotide exchange factor 40. (1707 aa)
ENSMFAP00000013287TNF receptor-associated factor. (474 aa)
TGM6Transglutaminase 6. (706 aa)
LINGO2Leucine rich repeat and Ig domain containing 2. (606 aa)
OMGOligodendrocyte myelin glycoprotein. (440 aa)
LOC102117118Ubiquitin-like domain-containing protein. (127 aa)
TNFRSF10DTNF receptor superfamily member 10d. (382 aa)
ENSMFAP00000013814UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. (558 aa)
ENSMFAP00000013942UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ENSMFAP00000015310Uncharacterized protein. (304 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (869 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (655 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1182 aa)
ENSMFAP00000015936Ubiquitin-like domain-containing protein. (144 aa)
TRAF1TNF receptor-associated factor. (416 aa)
AKAP13A-kinase anchoring protein 13. (2818 aa)
ENSMFAP00000016852Uncharacterized protein. (926 aa)
NGEFNeuronal guanine nucleotide exchange factor. (712 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (519 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
OBSCNObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (8221 aa)
TBK1TANK binding kinase 1. (729 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (931 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (1052 aa)
OTUD1OTU deubiquitinase 1. (480 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
SQSTM1Sequestosome 1. (440 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (423 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (333 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (381 aa)
BADBCL2 associated agonist of cell death. (167 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3079 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1154 aa)
ENSMFAP00000023078Uncharacterized protein; Belongs to the peptidase C14A family. (261 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC- mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits [...] (393 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (948 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1597 aa)
MAGMyelin associated glycoprotein. (626 aa)
KALRNKalirin RhoGEF kinase. (2986 aa)
NGFRNerve growth factor receptor. (427 aa)
ITSN1Intersectin 1. (1625 aa)
CLIP3CAP-Gly domain containing linker protein 3. (547 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
CLIP4CAP-Gly domain containing linker protein family member 4. (705 aa)
ABRABR activator of RhoGEF and GTPase. (861 aa)
ENSMFAP00000026546Uncharacterized protein. (117 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1387 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (571 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (841 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
ULK1Unc-51 like autophagy activating kinase 1. (967 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
TNFRSF1AUncharacterized protein. (455 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
ENSMFAP00000030877Uncharacterized protein. (382 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (657 aa)
USP21Ubiquitin specific peptidase 21; Belongs to the peptidase C19 family. (563 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
SPPL2ASignal peptide peptidase like 2A. (510 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
ENSMFAP00000032874Uncharacterized protein. (86 aa)
RTN4RReticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Pla [...] (522 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
RTN4Reticulon. (1193 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
AATFUncharacterized protein. (562 aa)
UBE2D3Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (149 aa)
BEX3Brain expressed X-linked 3. (123 aa)
MCF2MCF.2 cell line derived transforming sequence. (1001 aa)
NCSTNNcstrn_small domain-containing protein. (721 aa)
NSMAFUncharacterized protein. (939 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (150 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
ENSMFAP00000035756Uncharacterized protein. (197 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa)
OTULINLOTU deubiquitinase with linear linkage specificity like. (356 aa)
ARHGEF18Uncharacterized protein. (1015 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (352 aa)
RPS27ABrain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1573 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (660 aa)
WDR31WD repeat domain 31. (367 aa)
NET1Neuroepithelial cell transforming 1. (596 aa)
SHARPINSHANK associated RH domain interactor. (381 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (335 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (709 aa)
SPATA2Spermatogenesis associated 2. (520 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
ENSMFAP0000004071914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38. (777 aa)
UBBUncharacterized protein. (219 aa)
ECT2Epithelial cell transforming 2. (914 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (917 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (256 aa)
MAGED1MAGE family member D1. (834 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
SPPL2BSignal peptide peptidase like 2B. (319 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ITGB3BPIntegrin subunit beta 3 binding protein. (216 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1277 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
RNF31Uncharacterized protein. (1072 aa)
TAX1BP1Tax1 binding protein 1. (813 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
NAIPNLR family apoptosis inhibitory protein. (1403 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19. (781 aa)
UBE2D4Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
APH1BUncharacterized protein. (257 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in [...] (790 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1661 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ARHGEF17Rho guanine nucleotide exchange factor 17. (2068 aa)
TMEM198DUF4203 domain-containing protein. (360 aa)
UBE2L5Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
MCF2L2MCF.2 cell line derived transforming sequence-like 2. (1114 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (662 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa)
RHOAUncharacterized protein. (141 aa)
LOC102122430UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (146 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
ENSMFAP00000002560UBIQUITIN_CONJUGAT_2 domain-containing protein. (128 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (675 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ECT2LEpithelial cell transforming 2 like. (904 aa)
OTUD7BOTU deubiquitinase 7B. (843 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (1070 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
ENSMFAP00000003736BAG domain-containing protein. (360 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
GNA13G protein subunit alpha 13. (377 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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