Your Input: | |
| | ENSMFAP00000038331 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (119 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (445 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) |
| | TIAM1 | T cell lymphoma invasion and metastasis 1. (1591 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (655 aa) |
| | FGD3 | FYVE, RhoGEF and PH domain containing 3. (737 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa) |
| | ENSMFAP00000005841 | Ubiquitin-like domain-containing protein. (122 aa) |
| | ARHGEF4 | Uncharacterized protein. (1864 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (918 aa) |
| | ULK2 | Unc-51 like autophagy activating kinase 2. (1036 aa) |
| | PSENEN | Presenilin enhancer, gamma-secretase subunit. (101 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa) |
| | APH1A | Uncharacterized protein. (265 aa) |
| | TGM3 | TGc domain-containing protein. (836 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (800 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | ARHGEF9 | Cdc42 guanine nucleotide exchange factor 9. (552 aa) |
| | MADD | MAP kinase activating death domain. (1635 aa) |
| | TIAM2 | T cell lymphoma invasion and metastasis 2. (1725 aa) |
| | FGD1 | FYVE, RhoGEF and PH domain containing 1. (961 aa) |
| | ENSMFAP00000009883 | Ubiquitin-like domain-containing protein. (147 aa) |
| | ENSMFAP00000010148 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1031 aa) |
| | UBC | Ubiquitin C. (645 aa) |
| | LOC101864869 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). (620 aa) |
| | SESTD1 | SEC14 and spectrin domain containing 1. (696 aa) |
| | ARHGEF10 | Rho guanine nucleotide exchange factor 10. (1049 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | LOC102140123 | Ubiquitin-conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | ENSMFAP00000011880 | Ubiquitin-like domain-containing protein. (128 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (311 aa) |
| | ENSMFAP00000012290 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSMFAP00000012453 | Hist_deacetyl domain-containing protein. (223 aa) |
| | ARHGEF40 | Rho guanine nucleotide exchange factor 40. (1707 aa) |
| | ENSMFAP00000013287 | TNF receptor-associated factor. (474 aa) |
| | TGM6 | Transglutaminase 6. (706 aa) |
| | LINGO2 | Leucine rich repeat and Ig domain containing 2. (606 aa) |
| | OMG | Oligodendrocyte myelin glycoprotein. (440 aa) |
| | LOC102117118 | Ubiquitin-like domain-containing protein. (127 aa) |
| | TNFRSF10D | TNF receptor superfamily member 10d. (382 aa) |
| | ENSMFAP00000013814 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | ARHGEF3 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. (558 aa) |
| | ENSMFAP00000013942 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | ENSMFAP00000015310 | Uncharacterized protein. (304 aa) |
| | ARHGEF26 | Rho guanine nucleotide exchange factor 26. (869 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (875 aa) |
| | FGD2 | FYVE, RhoGEF and PH domain containing 2. (655 aa) |
| | MCF2L | MCF.2 cell line derived transforming sequence like. (1182 aa) |
| | ENSMFAP00000015936 | Ubiquitin-like domain-containing protein. (144 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | AKAP13 | A-kinase anchoring protein 13. (2818 aa) |
| | ENSMFAP00000016852 | Uncharacterized protein. (926 aa) |
| | NGEF | Neuronal guanine nucleotide exchange factor. (712 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (519 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa) |
| | OBSCN | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (8221 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | FGD4 | FYVE, RhoGEF and PH domain containing 4. (931 aa) |
| | BAG4 | BCL2 associated athanogene 4. (457 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1. (1052 aa) |
| | OTUD1 | OTU deubiquitinase 1. (480 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | SQSTM1 | Sequestosome 1. (440 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (333 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (381 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | TRIO | Trio Rho guanine nucleotide exchange factor. (3079 aa) |
| | PLEKHG5 | Pleckstrin homology and RhoGEF domain containing G5. (1154 aa) |
| | ENSMFAP00000023078 | Uncharacterized protein; Belongs to the peptidase C14A family. (261 aa) |
| | RACK1 | Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC- mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits [...] (393 aa) |
| | USP4 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (948 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | ARHGEF5 | Rho guanine nucleotide exchange factor 5. (1597 aa) |
| | MAG | Myelin associated glycoprotein. (626 aa) |
| | KALRN | Kalirin RhoGEF kinase. (2986 aa) |
| | NGFR | Nerve growth factor receptor. (427 aa) |
| | ITSN1 | Intersectin 1. (1625 aa) |
| | CLIP3 | CAP-Gly domain containing linker protein 3. (547 aa) |
| | ENSMFAP00000025317 | Hist_deacetyl domain-containing protein. (258 aa) |
| | CLIP4 | CAP-Gly domain containing linker protein family member 4. (705 aa) |
| | ABR | ABR activator of RhoGEF and GTPase. (861 aa) |
| | ENSMFAP00000026546 | Uncharacterized protein. (117 aa) |
| | KXD1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (298 aa) |
| | PLEKHG2 | Pleckstrin homology and RhoGEF domain containing G2. (1387 aa) |
| | OPTN | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (571 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | ARHGEF15 | Rho guanine nucleotide exchange factor 15. (841 aa) |
| | PRDM4 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (967 aa) |
| | RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | TNFRSF1A | Uncharacterized protein. (455 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) |
| | ENSMFAP00000030877 | Uncharacterized protein. (382 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (657 aa) |
| | USP21 | Ubiquitin specific peptidase 21; Belongs to the peptidase C19 family. (563 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | SPPL2A | Signal peptide peptidase like 2A. (510 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | ENSMFAP00000032874 | Uncharacterized protein. (86 aa) |
| | RTN4R | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Pla [...] (522 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (862 aa) |
| | RTN4 | Reticulon. (1193 aa) |
| | RASGRF2 | Ras protein specific guanine nucleotide releasing factor 2. (1237 aa) |
| | AATF | Uncharacterized protein. (562 aa) |
| | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (149 aa) |
| | BEX3 | Brain expressed X-linked 3. (123 aa) |
| | MCF2 | MCF.2 cell line derived transforming sequence. (1001 aa) |
| | NCSTN | Ncstrn_small domain-containing protein. (721 aa) |
| | NSMAF | Uncharacterized protein. (939 aa) |
| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (150 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (878 aa) |
| | NGF | Nerve growth factor; Belongs to the NGF-beta family. (123 aa) |
| | ENSMFAP00000035756 | Uncharacterized protein. (197 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa) |
| | OTULINL | OTU deubiquitinase with linear linkage specificity like. (356 aa) |
| | ARHGEF18 | Uncharacterized protein. (1015 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (352 aa) |
| | RPS27A | Brain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ARHGEF11 | Rho guanine nucleotide exchange factor 11. (1573 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (660 aa) |
| | WDR31 | WD repeat domain 31. (367 aa) |
| | NET1 | Neuroepithelial cell transforming 1. (596 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (381 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | ARHGEF39 | Rho guanine nucleotide exchange factor 39. (335 aa) |
| | ARHGEF16 | Rho guanine nucleotide exchange factor 16. (709 aa) |
| | SPATA2 | Spermatogenesis associated 2. (520 aa) |
| | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa) |
| | ENSMFAP00000040719 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa) |
| | ARHGEF38 | Rho guanine nucleotide exchange factor 38. (777 aa) |
| | UBB | Uncharacterized protein. (219 aa) |
| | ECT2 | Epithelial cell transforming 2. (914 aa) |
| | ARHGEF33 | Rho guanine nucleotide exchange factor 33. (917 aa) |
| | YWHAE | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (256 aa) |
| | MAGED1 | MAGE family member D1. (834 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | SPPL2B | Signal peptide peptidase like 2B. (319 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | ITGB3BP | Integrin subunit beta 3 binding protein. (216 aa) |
| | ARHGEF10L | Rho guanine nucleotide exchange factor 10 like. (1277 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (497 aa) |
| | RNF31 | Uncharacterized protein. (1072 aa) |
| | TAX1BP1 | Tax1 binding protein 1. (813 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (824 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | NAIP | NLR family apoptosis inhibitory protein. (1403 aa) |
| | ENSMFAP00000043974 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa) |
| | ARHGEF19 | Rho guanine nucleotide exchange factor 19. (781 aa) |
| | UBE2D4 | Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | APH1B | Uncharacterized protein. (257 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in [...] (790 aa) |
| | PREX1 | Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1661 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | ARHGEF17 | Rho guanine nucleotide exchange factor 17. (2068 aa) |
| | TMEM198 | DUF4203 domain-containing protein. (360 aa) |
| | UBE2L5 | Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | MCF2L2 | MCF.2 cell line derived transforming sequence-like 2. (1114 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (662 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa) |
| | RHOA | Uncharacterized protein. (141 aa) |
| | LOC102122430 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (146 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa) |
| | ENSMFAP00000002560 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (128 aa) |
| | ARHGEF37 | Rho guanine nucleotide exchange factor 37. (675 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | ECT2L | Epithelial cell transforming 2 like. (904 aa) |
| | OTUD7B | OTU deubiquitinase 7B. (843 aa) |
| | MIB2 | Mindbomb E3 ubiquitin protein ligase 2. (1070 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | ENSMFAP00000003736 | BAG domain-containing protein. (360 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
