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H2AJ | Histone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (129 aa) | ||||
PRMT6 | Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa) | ||||
ENSMFAP00000011762 | ANK_REP_REGION domain-containing protein. (116 aa) | ||||
H3C1 | H3 clustered histone 1. (136 aa) | ||||
LOC102130997 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
ENSMFAP00000011880 | Ubiquitin-like domain-containing protein. (128 aa) | ||||
ENSMFAP00000011989 | Uncharacterized protein; Belongs to the AAA ATPase family. (398 aa) | ||||
ENSMFAP00000012034 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
ENSMFAP00000012162 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
ENSMFAP00000012235 | Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa) | ||||
H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
ENSMFAP00000012290 | Ubiquitin-like domain-containing protein. (156 aa) | ||||
ENSMFAP00000012317 | Uncharacterized protein. (59 aa) | ||||
ENSMFAP00000012416 | annotation not available (136 aa) | ||||
CSF2 | Colony stimulating factor 2. (144 aa) | ||||
H2AC14 | Histone H2A; Belongs to the histone H2A family. (128 aa) | ||||
ENSMFAP00000012784 | annotation not available (136 aa) | ||||
WDR5B | WD repeat domain 5B. (330 aa) | ||||
ENSMFAP00000014622 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
ENSMFAP00000014776 | annotation not available (136 aa) | ||||
ENSMFAP00000014826 | annotation not available (136 aa) | ||||
SOCS4 | Suppressor of cytokine signaling 4. (440 aa) | ||||
ENSMFAP00000015048 | annotation not available (136 aa) | ||||
CBX4 | Chromobox 4. (558 aa) | ||||
ENSMFAP00000015065 | Histone H4. (103 aa) | ||||
ENSMFAP00000015112 | annotation not available (126 aa) | ||||
ENSMFAP00000015119 | Histone H4. (103 aa) | ||||
ENSMFAP00000015138 | Histone H4. (103 aa) | ||||
ENSMFAP00000015196 | Histone H4. (103 aa) | ||||
SETD1B | SET domain containing 1B, histone lysine methyltransferase. (1880 aa) | ||||
ENSMFAP00000015614 | Uncharacterized protein. (506 aa) | ||||
PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa) | ||||
RSPO3 | R-spondin 3. (293 aa) | ||||
SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1270 aa) | ||||
ENSMFAP00000015936 | Ubiquitin-like domain-containing protein. (144 aa) | ||||
TCF12 | Transcription factor 12. (706 aa) | ||||
CBX2 | Chromobox 2. (555 aa) | ||||
IL2RA | Interleukin 2 receptor alpha. (272 aa) | ||||
GATA1 | GATA binding protein 1. (413 aa) | ||||
SRC | Tyrosine-protein kinase. (542 aa) | ||||
PSMD8 | Proteasome 26S subunit, non-ATPase 8. (334 aa) | ||||
PSMD13 | PCI domain-containing protein. (399 aa) | ||||
PF4 | C-X-C motif chemokine. (101 aa) | ||||
PSMA2 | Proteasome subunit alpha type. (234 aa) | ||||
GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa) | ||||
SMARCD3 | SWIB domain-containing protein. (483 aa) | ||||
ARID1A | AT-rich interaction domain 1A. (2268 aa) | ||||
TCF3 | Transcription factor 3. (654 aa) | ||||
PSMD12 | PCI domain-containing protein. (456 aa) | ||||
RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa) | ||||
THBS1 | Thrombospondin 1. (1173 aa) | ||||
ENSMFAP00000020929 | Histone H2B; Belongs to the histone H2B family. (134 aa) | ||||
PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) | ||||
YAF2 | RanBP2-type domain-containing protein. (204 aa) | ||||
AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa) | ||||
PHC2 | Polyhomeotic homolog 2. (859 aa) | ||||
CTSV | Cathepsin V; Belongs to the peptidase C1 family. (334 aa) | ||||
ENSMFAP00000021715 | Proteasome subunit alpha type. (174 aa) | ||||
AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa) | ||||
ARID1B | AT-rich interaction domain 1B. (2295 aa) | ||||
IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) | ||||
AUTS2 | Activator of transcription and developmental regulator AUTS2. (1259 aa) | ||||
H3F3B | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
KAT2B | Lysine acetyltransferase 2B. (731 aa) | ||||
ENSMFAP00000022290 | Histone domain-containing protein. (113 aa) | ||||
PBRM1 | Polybromo 1. (1725 aa) | ||||
PSME1 | Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (249 aa) | ||||
SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1077 aa) | ||||
CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa) | ||||
ENSMFAP00000023218 | AAA domain-containing protein; Belongs to the AAA ATPase family. (366 aa) | ||||
SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa) | ||||
PRMT1 | Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa) | ||||
PSMA6 | Proteasome subunit alpha type. (252 aa) | ||||
IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) | ||||
TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa) | ||||
TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa) | ||||
SPI1 | Spi-1 proto-oncogene. (271 aa) | ||||
PSMC5 | 26S proteasome regulatory subunit T6; Belongs to the AAA ATPase family. (406 aa) | ||||
ENSMFAP00000025317 | Hist_deacetyl domain-containing protein. (258 aa) | ||||
NFE2 | Nuclear factor, erythroid 2. (373 aa) | ||||
PAX5 | Paired box 5. (391 aa) | ||||
ENSMFAP00000026020 | Uncharacterized protein. (300 aa) | ||||
TMEM62 | Transmembrane protein 62. (643 aa) | ||||
ENSMFAP00000026582 | HMG box domain-containing protein. (177 aa) | ||||
SERPINB13 | Serpin family B member 13; Belongs to the serpin family. (400 aa) | ||||
KXD1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa) | ||||
NFATC2 | Nuclear factor of activated T cells 2. (925 aa) | ||||
PSMB6 | Proteasome subunit beta. (250 aa) | ||||
PRMT8 | Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa) | ||||
DPY30 | Dpy-30 histone methyltransferase complex regulatory subunit. (99 aa) | ||||
H3F3A | annotation not available (136 aa) | ||||
ENSMFAP00000027900 | ANK_REP_REGION domain-containing protein. (163 aa) | ||||
KMT2E | Lysine methyltransferase 2E. (1859 aa) | ||||
CTSL | Cathepsin L; Belongs to the peptidase C1 family. (333 aa) | ||||
ITCH | E3 ubiquitin-protein ligase. (862 aa) | ||||
SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa) | ||||
SCML2 | Scm polycomb group protein like 2. (701 aa) | ||||
PSMC2 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa) | ||||
ELF2 | E74 like ETS transcription factor 2. (593 aa) | ||||
GATA3 | GATA binding protein 3. (444 aa) | ||||
CTLA4 | Cytotoxic T-lymphocyte associated protein 4. (223 aa) | ||||
PSMB10 | Proteasome subunit beta. (273 aa) | ||||
ENSMFAP00000031517 | Uncharacterized protein. (262 aa) | ||||
PSMA1 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (269 aa) | ||||
PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa) | ||||
SCMH1 | SAM domain-containing protein. (660 aa) | ||||
KMT2B | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (2716 aa) | ||||
YAP1 | Yes associated protein 1. (506 aa) | ||||
PSMD9 | PDZ domain-containing protein. (223 aa) | ||||
PSMA3 | Proteasome subunit alpha type. (255 aa) | ||||
AGO1 | Argonaute RISC component 1; Belongs to the argonaute family. (857 aa) | ||||
CBX6 | Chromobox 6. (397 aa) | ||||
PSMC1 | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) | ||||
FOXP3 | Forkhead box protein P3, C-terminally processed; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The s [...] (456 aa) | ||||
TJP1 | Tight junction protein 1; Belongs to the MAGUK family. (1767 aa) | ||||
SETD1A | SET domain containing 1A, histone lysine methyltransferase. (1710 aa) | ||||
ENSMFAP00000034298 | Histone H3; Belongs to the histone H3 family. (141 aa) | ||||
PSMD5 | 26S proteasome non-ATPase regulatory subunit 5; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity). (508 aa) | ||||
PSME4 | Proteasome activator subunit 4. (1844 aa) | ||||
ENSMFAP00000034774 | Uncharacterized protein. (158 aa) | ||||
PSMC3 | AAA domain-containing protein; Belongs to the AAA ATPase family. (451 aa) | ||||
ENSMFAP00000035194 | AAA domain-containing protein; Belongs to the AAA ATPase family. (418 aa) | ||||
TNRC6B | Trinucleotide repeat containing adaptor 6B. (1823 aa) | ||||
ENSMFAP00000035461 | WD_REPEATS_REGION domain-containing protein. (288 aa) | ||||
RUNX2 | RUNX family transcription factor 2. (627 aa) | ||||
CREBBP | CREB binding protein. (2442 aa) | ||||
PSMC4 | 26S proteasome regulatory subunit 6B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated wit [...] (418 aa) | ||||
BLK | Tyrosine-protein kinase. (505 aa) | ||||
OCLN | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (546 aa) | ||||
SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1569 aa) | ||||
RPS27A | Brain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa) | ||||
PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (912 aa) | ||||
PSMB9 | Proteasome subunit beta. (219 aa) | ||||
BMI1 | RING-type domain-containing protein. (326 aa) | ||||
LIFR | LIF receptor subunit alpha. (1097 aa) | ||||
PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa) | ||||
SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (493 aa) | ||||
GATA2 | GATA binding protein 2. (480 aa) | ||||
KMT2D | Lysine methyltransferase 2D. (5538 aa) | ||||
ARID2 | AT-rich interaction domain 2. (1815 aa) | ||||
ACTL6B | Actin like 6B; Belongs to the actin family. (426 aa) | ||||
TNFRSF18 | TNF receptor superfamily member 18. (241 aa) | ||||
PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) | ||||
PSMD7 | Proteasome 26S subunit, non-ATPase 7. (322 aa) | ||||
LDB2 | LIM domain binding 2. (383 aa) | ||||
RBBP5 | RB binding protein 5, histone lysine methyltransferase complex subunit. (548 aa) | ||||
GP1BA | Glycoprotein Ib platelet subunit alpha. (649 aa) | ||||
ENSMFAP00000039848 | MPN domain-containing protein. (149 aa) | ||||
IL3 | Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (151 aa) | ||||
KMT2C | Lysine methyltransferase 2C. (4802 aa) | ||||
PSME3 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa) | ||||
PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) | ||||
UBB | Uncharacterized protein. (219 aa) | ||||
LDB1 | LIM domain binding 1. (411 aa) | ||||
KMT2A | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3932 aa) | ||||
PAX2 | Paired box 2. (417 aa) | ||||
PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) | ||||
ENSMFAP00000042309 | Uncharacterized protein. (191 aa) | ||||
ENSMFAP00000042423 | Protein kinase domain-containing protein. (140 aa) | ||||
H2BC15 | Histone H2B; Belongs to the histone H2B family. (165 aa) | ||||
ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) | ||||
KCTD6 | Potassium channel tetramerization domain containing 6. (237 aa) | ||||
ENSMFAP00000043336 | Histone H2B; Belongs to the histone H2B family. (129 aa) | ||||
ENSMFAP00000043772 | Uncharacterized protein. (457 aa) | ||||
PSMB1 | Proteasome subunit beta. (241 aa) | ||||
ENSMFAP00000043974 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa) | ||||
WDR5 | WD repeat domain 5. (334 aa) | ||||
ITGA2B | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa) | ||||
SETD5 | SET domain containing 5. (1461 aa) | ||||
EP300 | E1A binding protein p300. (2414 aa) | ||||
ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa) | ||||
CTSK | Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (329 aa) | ||||
SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa) | ||||
PAX8 | Paired box 8. (456 aa) | ||||
PSMD4 | Proteasome 26S subunit, non-ATPase 4. (403 aa) | ||||
MYL9 | Myosin light chain 9. (172 aa) | ||||
PSMA7 | Proteasome subunit alpha type-7-like; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removi [...] (248 aa) | ||||
ENSMFAP00000012842 | Proteasome endopeptidase complex. (217 aa) | ||||
CLDN5 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa) | ||||
AGO2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (881 aa) | ||||
H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
G8F2Z2_MACFA | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
ENSMFAP00000013484 | Histone H4. (103 aa) | ||||
LOC102146894 | Histone domain-containing protein. (136 aa) | ||||
LOC102117118 | Ubiquitin-like domain-containing protein. (127 aa) | ||||
LMO3 | LIM domain only 3. (163 aa) | ||||
H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
ACTL6A | Actin-like protein 6A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remo [...] (429 aa) | ||||
HIST2H2BE | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
G8F5U3_MACFA | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
ZFPM1 | Zinc finger protein, FOG family member 1. (878 aa) | ||||
CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) | ||||
PSMA5 | Proteasome subunit alpha type. (241 aa) | ||||
CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) | ||||
CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) | ||||
CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) | ||||
PSMD3 | Proteasome 26S subunit, non-ATPase 3. (534 aa) | ||||
LMO2 | LIM domain only 2. (222 aa) | ||||
ENSMFAP00000001505 | Histone H2A; Belongs to the histone H2A family. (126 aa) | ||||
SCML1 | Scm polycomb group protein like 1. (329 aa) | ||||
ENSMFAP00000001720 | AAA domain-containing protein; Belongs to the AAA ATPase family. (384 aa) | ||||
LOC102121517 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (103 aa) | ||||
LOC102138275 | Histone H4. (103 aa) | ||||
ENSMFAP00000002027 | Histone H2A; Belongs to the histone H2A family. (117 aa) | ||||
H2AZ2 | Histone H2A; Belongs to the histone H2A family. (128 aa) | ||||
H2BC13 | Histone H2B; Belongs to the histone H2B family. (136 aa) | ||||
MYB | MYB proto-oncogene, transcription factor. (759 aa) | ||||
PSMD6 | Proteasome 26S subunit, non-ATPase 6. (442 aa) | ||||
CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) | ||||
HIPK2 | Homeodomain interacting protein kinase 2. (1196 aa) | ||||
ENSMFAP00000003583 | Uncharacterized protein. (379 aa) | ||||
RYBP | RING1 and YY1 binding protein. (230 aa) | ||||
ENSMFAP00000003955 | ETS domain-containing protein. (463 aa) | ||||
NR4A3 | Nuclear receptor subfamily 4 group A member 3. (637 aa) | ||||
ENSMFAP00000004537 | Prot_ATP_ID_OB domain-containing protein. (166 aa) | ||||
ASH2L | ASH2 like, histone lysine methyltransferase complex subunit. (616 aa) | ||||
PSMA4 | Proteasome subunit alpha type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (261 aa) | ||||
AXIN1 | Axin 1. (867 aa) | ||||
PSMD14 | 26S proteasome regulatory subunit N11. (310 aa) | ||||
MOV10 | Mov10 RISC complex RNA helicase. (1003 aa) | ||||
PSMB2 | Proteasome subunit beta. (201 aa) | ||||
PML | Promyelocytic leukemia. (882 aa) | ||||
ENSMFAP00000005693 | CSN8_PSD8_EIF3K domain-containing protein. (226 aa) | ||||
CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) | ||||
H2AZ1 | Histone H2A; Belongs to the histone H2A family. (128 aa) | ||||
ENSMFAP00000005841 | Ubiquitin-like domain-containing protein. (122 aa) | ||||
PSMB7 | Proteasome subunit beta. (302 aa) | ||||
PSMB8 | Proteasome subunit beta. (276 aa) | ||||
RING1 | Ring finger protein 1. (412 aa) | ||||
PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) | ||||
PSMF1 | Proteasome inhibitor subunit 1. (271 aa) | ||||
ENSMFAP00000006175 | AAA domain-containing protein. (372 aa) | ||||
PSMB3 | Proteasome subunit beta. (205 aa) | ||||
LGALS3 | Galectin 3. (248 aa) | ||||
SIN3A | SIN3 transcription regulator family member A. (1273 aa) | ||||
ENSMFAP00000006991 | Histone H2B; Belongs to the histone H2B family. (149 aa) | ||||
PCGF5 | Polycomb group ring finger 5. (256 aa) | ||||
PSMB5 | Proteasome subunit beta. (263 aa) | ||||
RNF2 | Ring finger protein 2. (336 aa) | ||||
CBX8 | Chromobox 8. (420 aa) | ||||
PHC3 | Polyhomeotic homolog 3. (995 aa) | ||||
ELF1 | E74 like ETS transcription factor 1. (619 aa) | ||||
PSME2 | Proteasome activator subunit 2. (239 aa) | ||||
SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (376 aa) | ||||
LMO1 | LIM domain only 1. (160 aa) | ||||
SIN3B | SIN3 transcription regulator family member B. (1159 aa) | ||||
CBFB | Core-binding factor subunit beta. (182 aa) | ||||
ENSMFAP00000008526 | Histone H2A; Belongs to the histone H2A family. (106 aa) | ||||
HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) | ||||
ELF4 | E74 like ETS transcription factor 4. (662 aa) | ||||
MNAT1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa) | ||||
CSNK2B | Uncharacterized protein. (298 aa) | ||||
ENSMFAP00000009536 | Proteasome subunit alpha type. (236 aa) | ||||
HIST1H3B | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
LOC102147067 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
HIST1H2BO | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
ENSMFAP00000009883 | Ubiquitin-like domain-containing protein. (147 aa) | ||||
SOCS3 | Suppressor of cytokine signaling 3. (225 aa) | ||||
H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
ENSMFAP00000009974 | Histone H4. (103 aa) | ||||
ENSMFAP00000010006 | annotation not available (136 aa) | ||||
ENSMFAP00000010019 | ANK_REP_REGION domain-containing protein. (159 aa) | ||||
ENSMFAP00000010034 | annotation not available (136 aa) | ||||
ENSMFAP00000010040 | Histone domain-containing protein; Belongs to the histone H2B family. (67 aa) | ||||
H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) | ||||
H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) | ||||
ENSMFAP00000010148 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa) | ||||
UBC | Ubiquitin C. (645 aa) | ||||
ENSMFAP00000010517 | Histone H4. (103 aa) | ||||
LOC101864869 | Ubiquitin-like domain-containing protein. (156 aa) | ||||
LOC102138794 | RING-type domain-containing protein. (321 aa) | ||||
LOC102136612 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) | ||||
ENSMFAP00000010627 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
H2BC11 | Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa) | ||||
ENSMFAP00000010686 | Histone H4. (103 aa) | ||||
H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) | ||||
CCNH | Cyclin-H; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout t [...] (325 aa) | ||||
H2AC6 | Histone H2A; Belongs to the histone H2A family. (130 aa) | ||||
PSMB11 | Proteasome subunit beta. (300 aa) | ||||
ENSMFAP00000010848 | Histone H4. (103 aa) | ||||
ENSMFAP00000010867 | Histone H4. (103 aa) | ||||
ENSMFAP00000010884 | Histone H4. (103 aa) | ||||
PSMA8 | Proteasome endopeptidase complex. (132 aa) | ||||
PHC1 | Polyhomeotic homolog 1. (1003 aa) | ||||
ENSMFAP00000011138 | Histone H4. (103 aa) | ||||
G7P2P1_MACFA | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
H2AC7 | Histone H2A; Belongs to the histone H2A family. (130 aa) | ||||
ENSMFAP00000011394 | annotation not available (126 aa) | ||||
ENSMFAP00000011563 | annotation not available (136 aa) |