STRINGSTRING
H2AJ H2AJ PRMT6 PRMT6 ENSMFAP00000011762 ENSMFAP00000011762 H3C1 H3C1 LOC102130997 LOC102130997 ENSMFAP00000011880 ENSMFAP00000011880 ENSMFAP00000011989 ENSMFAP00000011989 ENSMFAP00000012034 ENSMFAP00000012034 ENSMFAP00000012162 ENSMFAP00000012162 ENSMFAP00000012235 ENSMFAP00000012235 H2BU1 H2BU1 ENSMFAP00000012290 ENSMFAP00000012290 ENSMFAP00000012317 ENSMFAP00000012317 ENSMFAP00000012416 ENSMFAP00000012416 CSF2 CSF2 H2AC14 H2AC14 ENSMFAP00000012784 ENSMFAP00000012784 WDR5B WDR5B ENSMFAP00000014622 ENSMFAP00000014622 ENSMFAP00000014776 ENSMFAP00000014776 ENSMFAP00000014826 ENSMFAP00000014826 SOCS4 SOCS4 ENSMFAP00000015048 ENSMFAP00000015048 CBX4 CBX4 ENSMFAP00000015065 ENSMFAP00000015065 ENSMFAP00000015112 ENSMFAP00000015112 ENSMFAP00000015119 ENSMFAP00000015119 ENSMFAP00000015138 ENSMFAP00000015138 ENSMFAP00000015196 ENSMFAP00000015196 SETD1B SETD1B ENSMFAP00000015614 ENSMFAP00000015614 PRKCB PRKCB RSPO3 RSPO3 SMARCC2 SMARCC2 ENSMFAP00000015936 ENSMFAP00000015936 TCF12 TCF12 CBX2 CBX2 IL2RA IL2RA GATA1 GATA1 SRC SRC PSMD8 PSMD8 PSMD13 PSMD13 PF4 PF4 PSMA2 PSMA2 GPAM GPAM SMARCD3 SMARCD3 ARID1A ARID1A TCF3 TCF3 PSMD12 PSMD12 RUNX1 RUNX1 THBS1 THBS1 ENSMFAP00000020929 ENSMFAP00000020929 PSMB4 PSMB4 YAF2 YAF2 AGO4 AGO4 PHC2 PHC2 CTSV CTSV ENSMFAP00000021715 ENSMFAP00000021715 AGO3 AGO3 ARID1B ARID1B IL2 IL2 AUTS2 AUTS2 H3F3B H3F3B KAT2B KAT2B ENSMFAP00000022290 ENSMFAP00000022290 PBRM1 PBRM1 PSME1 PSME1 SMARCC1 SMARCC1 CSNK2A2 CSNK2A2 ENSMFAP00000023218 ENSMFAP00000023218 SMARCA4 SMARCA4 PRMT1 PRMT1 PSMA6 PSMA6 IFNG IFNG TP73 TP73 TAL1 TAL1 SPI1 SPI1 PSMC5 PSMC5 ENSMFAP00000025317 ENSMFAP00000025317 NFE2 NFE2 PAX5 PAX5 ENSMFAP00000026020 ENSMFAP00000026020 TMEM62 TMEM62 ENSMFAP00000026582 ENSMFAP00000026582 SERPINB13 SERPINB13 KXD1 KXD1 NFATC2 NFATC2 PSMB6 PSMB6 PRMT8 PRMT8 DPY30 DPY30 H3F3A H3F3A ENSMFAP00000027900 ENSMFAP00000027900 KMT2E KMT2E CTSL CTSL ITCH ITCH SMARCE1 SMARCE1 SCML2 SCML2 PSMC2 PSMC2 ELF2 ELF2 GATA3 GATA3 CTLA4 CTLA4 PSMB10 PSMB10 ENSMFAP00000031517 ENSMFAP00000031517 PSMA1 PSMA1 PSMC6 PSMC6 SCMH1 SCMH1 KMT2B KMT2B YAP1 YAP1 PSMD9 PSMD9 PSMA3 PSMA3 AGO1 AGO1 CBX6 CBX6 PSMC1 PSMC1 FOXP3 FOXP3 TJP1 TJP1 SETD1A SETD1A ENSMFAP00000034298 ENSMFAP00000034298 PSMD5 PSMD5 PSME4 PSME4 ENSMFAP00000034774 ENSMFAP00000034774 PSMC3 PSMC3 ENSMFAP00000035194 ENSMFAP00000035194 TNRC6B TNRC6B ENSMFAP00000035461 ENSMFAP00000035461 RUNX2 RUNX2 CREBBP CREBBP PSMC4 PSMC4 BLK BLK OCLN OCLN SMARCA2 SMARCA2 RPS27A RPS27A PSMD2 PSMD2 PSMB9 PSMB9 BMI1 BMI1 LIFR LIFR PRKCQ PRKCQ SMARCD2 SMARCD2 GATA2 GATA2 KMT2D KMT2D ARID2 ARID2 ACTL6B ACTL6B TNFRSF18 TNFRSF18 PSMD10 PSMD10 PSMD7 PSMD7 LDB2 LDB2 RBBP5 RBBP5 GP1BA GP1BA ENSMFAP00000039848 ENSMFAP00000039848 IL3 IL3 KMT2C KMT2C PSME3 PSME3 PTPN11 PTPN11 UBB UBB LDB1 LDB1 KMT2A KMT2A PAX2 PAX2 PSMD11 PSMD11 ENSMFAP00000042309 ENSMFAP00000042309 ENSMFAP00000042423 ENSMFAP00000042423 H2BC15 H2BC15 ESR1 ESR1 KCTD6 KCTD6 ENSMFAP00000043336 ENSMFAP00000043336 ENSMFAP00000043772 ENSMFAP00000043772 PSMB1 PSMB1 ENSMFAP00000043974 ENSMFAP00000043974 WDR5 WDR5 ITGA2B ITGA2B SETD5 SETD5 EP300 EP300 ABL1 ABL1 CTSK CTSK SMARCD1 SMARCD1 PAX8 PAX8 PSMD4 PSMD4 MYL9 MYL9 PSMA7 PSMA7 ENSMFAP00000012842 ENSMFAP00000012842 CLDN5 CLDN5 AGO2 AGO2 H2BC5 H2BC5 G8F2Z2_MACFA G8F2Z2_MACFA ENSMFAP00000013484 ENSMFAP00000013484 LOC102146894 LOC102146894 LOC102117118 LOC102117118 LMO3 LMO3 H2BC3 H2BC3 ACTL6A ACTL6A HIST2H2BE HIST2H2BE G8F5U3_MACFA G8F5U3_MACFA ZFPM1 ZFPM1 CCND3 CCND3 PSMA5 PSMA5 CCND1 CCND1 CSNK2A1 CSNK2A1 CCND2 CCND2 PSMD3 PSMD3 LMO2 LMO2 ENSMFAP00000001505 ENSMFAP00000001505 SCML1 SCML1 ENSMFAP00000001720 ENSMFAP00000001720 LOC102121517 LOC102121517 LOC102138275 LOC102138275 ENSMFAP00000002027 ENSMFAP00000002027 H2AZ2 H2AZ2 H2BC13 H2BC13 MYB MYB PSMD6 PSMD6 CDK7 CDK7 HIPK2 HIPK2 ENSMFAP00000003583 ENSMFAP00000003583 RYBP RYBP ENSMFAP00000003955 ENSMFAP00000003955 NR4A3 NR4A3 ENSMFAP00000004537 ENSMFAP00000004537 ASH2L ASH2L PSMA4 PSMA4 AXIN1 AXIN1 PSMD14 PSMD14 MOV10 MOV10 PSMB2 PSMB2 PML PML ENSMFAP00000005693 ENSMFAP00000005693 CDK6 CDK6 H2AZ1 H2AZ1 ENSMFAP00000005841 ENSMFAP00000005841 PSMB7 PSMB7 PSMB8 PSMB8 RING1 RING1 PSMD1 PSMD1 PSMF1 PSMF1 ENSMFAP00000006175 ENSMFAP00000006175 PSMB3 PSMB3 LGALS3 LGALS3 SIN3A SIN3A ENSMFAP00000006991 ENSMFAP00000006991 PCGF5 PCGF5 PSMB5 PSMB5 RNF2 RNF2 CBX8 CBX8 PHC3 PHC3 ELF1 ELF1 PSME2 PSME2 SMARCB1 SMARCB1 LMO1 LMO1 SIN3B SIN3B CBFB CBFB ENSMFAP00000008526 ENSMFAP00000008526 HDAC1 HDAC1 ELF4 ELF4 MNAT1 MNAT1 CSNK2B CSNK2B ENSMFAP00000009536 ENSMFAP00000009536 HIST1H3B HIST1H3B LOC102147067 LOC102147067 HIST1H2BO HIST1H2BO ENSMFAP00000009883 ENSMFAP00000009883 SOCS3 SOCS3 H2BC14 H2BC14 ENSMFAP00000009974 ENSMFAP00000009974 ENSMFAP00000010006 ENSMFAP00000010006 ENSMFAP00000010019 ENSMFAP00000010019 ENSMFAP00000010034 ENSMFAP00000010034 ENSMFAP00000010040 ENSMFAP00000010040 H2BC1 H2BC1 H2AC20 H2AC20 ENSMFAP00000010148 ENSMFAP00000010148 UBC UBC ENSMFAP00000010517 ENSMFAP00000010517 LOC101864869 LOC101864869 LOC102138794 LOC102138794 LOC102136612 LOC102136612 ENSMFAP00000010627 ENSMFAP00000010627 H2BC11 H2BC11 ENSMFAP00000010686 ENSMFAP00000010686 H2AX H2AX CCNH CCNH H2AC6 H2AC6 PSMB11 PSMB11 ENSMFAP00000010848 ENSMFAP00000010848 ENSMFAP00000010867 ENSMFAP00000010867 ENSMFAP00000010884 ENSMFAP00000010884 PSMA8 PSMA8 PHC1 PHC1 ENSMFAP00000011138 ENSMFAP00000011138 G7P2P1_MACFA G7P2P1_MACFA H2AC7 H2AC7 ENSMFAP00000011394 ENSMFAP00000011394 ENSMFAP00000011563 ENSMFAP00000011563
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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H2AJHistone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (129 aa)
PRMT6Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
ENSMFAP00000011762ANK_REP_REGION domain-containing protein. (116 aa)
H3C1H3 clustered histone 1. (136 aa)
LOC102130997Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000011880Ubiquitin-like domain-containing protein. (128 aa)
ENSMFAP00000011989Uncharacterized protein; Belongs to the AAA ATPase family. (398 aa)
ENSMFAP00000012034Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000012162Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000012235Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMFAP00000012290Ubiquitin-like domain-containing protein. (156 aa)
ENSMFAP00000012317Uncharacterized protein. (59 aa)
ENSMFAP00000012416annotation not available (136 aa)
CSF2Colony stimulating factor 2. (144 aa)
H2AC14Histone H2A; Belongs to the histone H2A family. (128 aa)
ENSMFAP00000012784annotation not available (136 aa)
WDR5BWD repeat domain 5B. (330 aa)
ENSMFAP00000014622Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMFAP00000014776annotation not available (136 aa)
ENSMFAP00000014826annotation not available (136 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
ENSMFAP00000015048annotation not available (136 aa)
CBX4Chromobox 4. (558 aa)
ENSMFAP00000015065Histone H4. (103 aa)
ENSMFAP00000015112annotation not available (126 aa)
ENSMFAP00000015119Histone H4. (103 aa)
ENSMFAP00000015138Histone H4. (103 aa)
ENSMFAP00000015196Histone H4. (103 aa)
SETD1BSET domain containing 1B, histone lysine methyltransferase. (1880 aa)
ENSMFAP00000015614Uncharacterized protein. (506 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
RSPO3R-spondin 3. (293 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1270 aa)
ENSMFAP00000015936Ubiquitin-like domain-containing protein. (144 aa)
TCF12Transcription factor 12. (706 aa)
CBX2Chromobox 2. (555 aa)
IL2RAInterleukin 2 receptor alpha. (272 aa)
GATA1GATA binding protein 1. (413 aa)
SRCTyrosine-protein kinase. (542 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (334 aa)
PSMD13PCI domain-containing protein. (399 aa)
PF4C-X-C motif chemokine. (101 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
SMARCD3SWIB domain-containing protein. (483 aa)
ARID1AAT-rich interaction domain 1A. (2268 aa)
TCF3Transcription factor 3. (654 aa)
PSMD12PCI domain-containing protein. (456 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
THBS1Thrombospondin 1. (1173 aa)
ENSMFAP00000020929Histone H2B; Belongs to the histone H2B family. (134 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
YAF2RanBP2-type domain-containing protein. (204 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
PHC2Polyhomeotic homolog 2. (859 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (334 aa)
ENSMFAP00000021715Proteasome subunit alpha type. (174 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
ARID1BAT-rich interaction domain 1B. (2295 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1259 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
KAT2BLysine acetyltransferase 2B. (731 aa)
ENSMFAP00000022290Histone domain-containing protein. (113 aa)
PBRM1Polybromo 1. (1725 aa)
PSME1Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (249 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1077 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
ENSMFAP00000023218AAA domain-containing protein; Belongs to the AAA ATPase family. (366 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
PSMC526S proteasome regulatory subunit T6; Belongs to the AAA ATPase family. (406 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
NFE2Nuclear factor, erythroid 2. (373 aa)
PAX5Paired box 5. (391 aa)
ENSMFAP00000026020Uncharacterized protein. (300 aa)
TMEM62Transmembrane protein 62. (643 aa)
ENSMFAP00000026582HMG box domain-containing protein. (177 aa)
SERPINB13Serpin family B member 13; Belongs to the serpin family. (400 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
PSMB6Proteasome subunit beta. (250 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
DPY30Dpy-30 histone methyltransferase complex regulatory subunit. (99 aa)
H3F3Aannotation not available (136 aa)
ENSMFAP00000027900ANK_REP_REGION domain-containing protein. (163 aa)
KMT2ELysine methyltransferase 2E. (1859 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
SCML2Scm polycomb group protein like 2. (701 aa)
PSMC226S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa)
ELF2E74 like ETS transcription factor 2. (593 aa)
GATA3GATA binding protein 3. (444 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
PSMB10Proteasome subunit beta. (273 aa)
ENSMFAP00000031517Uncharacterized protein. (262 aa)
PSMA1Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (269 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
SCMH1SAM domain-containing protein. (660 aa)
KMT2BHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (2716 aa)
YAP1Yes associated protein 1. (506 aa)
PSMD9PDZ domain-containing protein. (223 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
CBX6Chromobox 6. (397 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
FOXP3Forkhead box protein P3, C-terminally processed; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The s [...] (456 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1767 aa)
SETD1ASET domain containing 1A, histone lysine methyltransferase. (1710 aa)
ENSMFAP00000034298Histone H3; Belongs to the histone H3 family. (141 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity). (508 aa)
PSME4Proteasome activator subunit 4. (1844 aa)
ENSMFAP00000034774Uncharacterized protein. (158 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (451 aa)
ENSMFAP00000035194AAA domain-containing protein; Belongs to the AAA ATPase family. (418 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1823 aa)
ENSMFAP00000035461WD_REPEATS_REGION domain-containing protein. (288 aa)
RUNX2RUNX family transcription factor 2. (627 aa)
CREBBPCREB binding protein. (2442 aa)
PSMC426S proteasome regulatory subunit 6B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated wit [...] (418 aa)
BLKTyrosine-protein kinase. (505 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (546 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1569 aa)
RPS27ABrain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (912 aa)
PSMB9Proteasome subunit beta. (219 aa)
BMI1RING-type domain-containing protein. (326 aa)
LIFRLIF receptor subunit alpha. (1097 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (493 aa)
GATA2GATA binding protein 2. (480 aa)
KMT2DLysine methyltransferase 2D. (5538 aa)
ARID2AT-rich interaction domain 2. (1815 aa)
ACTL6BActin like 6B; Belongs to the actin family. (426 aa)
TNFRSF18TNF receptor superfamily member 18. (241 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
LDB2LIM domain binding 2. (383 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (548 aa)
GP1BAGlycoprotein Ib platelet subunit alpha. (649 aa)
ENSMFAP00000039848MPN domain-containing protein. (149 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (151 aa)
KMT2CLysine methyltransferase 2C. (4802 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
UBBUncharacterized protein. (219 aa)
LDB1LIM domain binding 1. (411 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3932 aa)
PAX2Paired box 2. (417 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
ENSMFAP00000042309Uncharacterized protein. (191 aa)
ENSMFAP00000042423Protein kinase domain-containing protein. (140 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (165 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
KCTD6Potassium channel tetramerization domain containing 6. (237 aa)
ENSMFAP00000043336Histone H2B; Belongs to the histone H2B family. (129 aa)
ENSMFAP00000043772Uncharacterized protein. (457 aa)
PSMB1Proteasome subunit beta. (241 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
WDR5WD repeat domain 5. (334 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
SETD5SET domain containing 5. (1461 aa)
EP300E1A binding protein p300. (2414 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa)
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (329 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa)
PAX8Paired box 8. (456 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (403 aa)
MYL9Myosin light chain 9. (172 aa)
PSMA7Proteasome subunit alpha type-7-like; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removi [...] (248 aa)
ENSMFAP00000012842Proteasome endopeptidase complex. (217 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (881 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
G8F2Z2_MACFAHistone H2B; Belongs to the histone H2B family. (126 aa)
ENSMFAP00000013484Histone H4. (103 aa)
LOC102146894Histone domain-containing protein. (136 aa)
LOC102117118Ubiquitin-like domain-containing protein. (127 aa)
LMO3LIM domain only 3. (163 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
ACTL6AActin-like protein 6A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remo [...] (429 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
G8F5U3_MACFAHistone H3; Belongs to the histone H3 family. (136 aa)
ZFPM1Zinc finger protein, FOG family member 1. (878 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
LMO2LIM domain only 2. (222 aa)
ENSMFAP00000001505Histone H2A; Belongs to the histone H2A family. (126 aa)
SCML1Scm polycomb group protein like 1. (329 aa)
ENSMFAP00000001720AAA domain-containing protein; Belongs to the AAA ATPase family. (384 aa)
LOC102121517Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (103 aa)
LOC102138275Histone H4. (103 aa)
ENSMFAP00000002027Histone H2A; Belongs to the histone H2A family. (117 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (136 aa)
MYBMYB proto-oncogene, transcription factor. (759 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
HIPK2Homeodomain interacting protein kinase 2. (1196 aa)
ENSMFAP00000003583Uncharacterized protein. (379 aa)
RYBPRING1 and YY1 binding protein. (230 aa)
ENSMFAP00000003955ETS domain-containing protein. (463 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
ENSMFAP00000004537Prot_ATP_ID_OB domain-containing protein. (166 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (616 aa)
PSMA4Proteasome subunit alpha type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (261 aa)
AXIN1Axin 1. (867 aa)
PSMD1426S proteasome regulatory subunit N11. (310 aa)
MOV10Mov10 RISC complex RNA helicase. (1003 aa)
PSMB2Proteasome subunit beta. (201 aa)
PMLPromyelocytic leukemia. (882 aa)
ENSMFAP00000005693CSN8_PSD8_EIF3K domain-containing protein. (226 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
ENSMFAP00000005841Ubiquitin-like domain-containing protein. (122 aa)
PSMB7Proteasome subunit beta. (302 aa)
PSMB8Proteasome subunit beta. (276 aa)
RING1Ring finger protein 1. (412 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
ENSMFAP00000006175AAA domain-containing protein. (372 aa)
PSMB3Proteasome subunit beta. (205 aa)
LGALS3Galectin 3. (248 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
ENSMFAP00000006991Histone H2B; Belongs to the histone H2B family. (149 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
PSMB5Proteasome subunit beta. (263 aa)
RNF2Ring finger protein 2. (336 aa)
CBX8Chromobox 8. (420 aa)
PHC3Polyhomeotic homolog 3. (995 aa)
ELF1E74 like ETS transcription factor 1. (619 aa)
PSME2Proteasome activator subunit 2. (239 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (376 aa)
LMO1LIM domain only 1. (160 aa)
SIN3BSIN3 transcription regulator family member B. (1159 aa)
CBFBCore-binding factor subunit beta. (182 aa)
ENSMFAP00000008526Histone H2A; Belongs to the histone H2A family. (106 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ELF4E74 like ETS transcription factor 4. (662 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
CSNK2BUncharacterized protein. (298 aa)
ENSMFAP00000009536Proteasome subunit alpha type. (236 aa)
HIST1H3BHistone H3; Belongs to the histone H3 family. (136 aa)
LOC102147067Histone H3; Belongs to the histone H3 family. (136 aa)
HIST1H2BOHistone H2B; Belongs to the histone H2B family. (126 aa)
ENSMFAP00000009883Ubiquitin-like domain-containing protein. (147 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMFAP00000009974Histone H4. (103 aa)
ENSMFAP00000010006annotation not available (136 aa)
ENSMFAP00000010019ANK_REP_REGION domain-containing protein. (159 aa)
ENSMFAP00000010034annotation not available (136 aa)
ENSMFAP00000010040Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
UBCUbiquitin C. (645 aa)
ENSMFAP00000010517Histone H4. (103 aa)
LOC101864869Ubiquitin-like domain-containing protein. (156 aa)
LOC102138794RING-type domain-containing protein. (321 aa)
LOC102136612Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
ENSMFAP00000010627Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC11Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
ENSMFAP00000010686Histone H4. (103 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
CCNHCyclin-H; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout t [...] (325 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
PSMB11Proteasome subunit beta. (300 aa)
ENSMFAP00000010848Histone H4. (103 aa)
ENSMFAP00000010867Histone H4. (103 aa)
ENSMFAP00000010884Histone H4. (103 aa)
PSMA8Proteasome endopeptidase complex. (132 aa)
PHC1Polyhomeotic homolog 1. (1003 aa)
ENSMFAP00000011138Histone H4. (103 aa)
G7P2P1_MACFAHistone H2B; Belongs to the histone H2B family. (126 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSMFAP00000011394annotation not available (126 aa)
ENSMFAP00000011563annotation not available (136 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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