STRINGSTRING
PSEN1 PSEN1 UBB UBB DLL1 DLL1 ENSMFAP00000043809 ENSMFAP00000043809 WWP2 WWP2 APH1B APH1B NCSTN NCSTN DLL4 DLL4 EGF EGF ADAM10 ADAM10 RPS27A RPS27A JAG2 JAG2 EGFR EGFR NOTCH3 NOTCH3 YBX1 YBX1 NEURL1B NEURL1B KXD1 KXD1 MIB1 MIB1 TACC3 TACC3 JAG1 JAG1 ENSMFAP00000012290 ENSMFAP00000012290 ENSMFAP00000011880 ENSMFAP00000011880 ENSMFAP00000011451 ENSMFAP00000011451 LOC101864869 LOC101864869 UBC UBC ENSMFAP00000009883 ENSMFAP00000009883 NEURL1 NEURL1 APH1A APH1A PSENEN PSENEN MIB2 MIB2 PSEN2 PSEN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa)
UBBUncharacterized protein. (219 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
ENSMFAP00000043809Uncharacterized protein. (125 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
APH1BUncharacterized protein. (257 aa)
NCSTNNcstrn_small domain-containing protein. (721 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
RPS27ABrain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1075 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
NOTCH3Notch receptor 3. (2300 aa)
YBX1Y-box binding protein 1. (324 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (555 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
TACC3Transforming acidic coiled-coil containing protein 3. (817 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ENSMFAP00000012290Ubiquitin-like domain-containing protein. (156 aa)
ENSMFAP00000011880Ubiquitin-like domain-containing protein. (128 aa)
ENSMFAP00000011451Uncharacterized protein. (144 aa)
LOC101864869Ubiquitin-like domain-containing protein. (156 aa)
UBCUbiquitin C. (645 aa)
ENSMFAP00000009883Ubiquitin-like domain-containing protein. (147 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
APH1AUncharacterized protein. (265 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (1070 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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