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| | GTF2A1 | General transcription factor IIA subunit 1. (376 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa) |
| | KPNA2 | Importin subunit alpha; Functions in nuclear protein import. (529 aa) |
| | JUND | JunD proto-oncogene, AP-1 transcription factor subunit. (325 aa) |
| | ENSMFAP00000001505 | Histone H2A; Belongs to the histone H2A family. (126 aa) |
| | LOC102121517 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (103 aa) |
| | LOC102138275 | Histone H4. (103 aa) |
| | ENSMFAP00000002027 | Histone H2A; Belongs to the histone H2A family. (117 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | YY1 | YY1 transcription factor. (414 aa) |
| | H2BC13 | Histone H2B; Belongs to the histone H2B family. (136 aa) |
| | MYB | MYB proto-oncogene, transcription factor. (759 aa) |
| | ENSMFAP00000003444 | TFIIA_gamma_C domain-containing protein. (74 aa) |
| | POLR2L | RNA polymerase II subunit L. (67 aa) |
| | LOC102137233 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | ENSMFAP00000004828 | Uncharacterized protein. (67 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | MOV10 | Mov10 RISC complex RNA helicase. (1003 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (557 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | H2AZ1 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | USF2 | Upstream transcription factor 2, c-fos interacting. (380 aa) |
| | POLR2F | RNA polymerase II subunit F. (158 aa) |
| | ENSMFAP00000006991 | Histone H2B; Belongs to the histone H2B family. (149 aa) |
| | POLR2G | S1 domain-containing protein. (234 aa) |
| | NR5A2 | Nuclear receptor subfamily 5 group A member 2. (541 aa) |
| | CBFB | Core-binding factor subunit beta. (182 aa) |
| | ENSMFAP00000008526 | Histone H2A; Belongs to the histone H2A family. (106 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | EBAG9 | Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (258 aa) |
| | HIST1H3B | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC102147067 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | HIST1H2BO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMFAP00000009974 | Histone H4. (103 aa) |
| | ENSMFAP00000010006 | annotation not available (136 aa) |
| | ENSMFAP00000010034 | annotation not available (136 aa) |
| | ENSMFAP00000010040 | Histone domain-containing protein; Belongs to the histone H2B family. (67 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | ENSMFAP00000010148 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa) |
| | POLR2A | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (982 aa) |
| | BCL2 | BCL2 apoptosis regulator. (242 aa) |
| | ENSMFAP00000010517 | Histone H4. (103 aa) |
| | LOC102126330 | Importin subunit alpha; Functions in nuclear protein import. (504 aa) |
| | LOC102136612 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | ENSMFAP00000010627 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | H2BC11 | Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa) |
| | ENSMFAP00000010686 | Histone H4. (103 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | H2AC6 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | ENSMFAP00000010848 | Histone H4. (103 aa) |
| | ENSMFAP00000010867 | Histone H4. (103 aa) |
| | ENSMFAP00000010884 | Histone H4. (103 aa) |
| | ENSMFAP00000011138 | Histone H4. (103 aa) |
| | G7P2P1_MACFA | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | H2AC7 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | ENSMFAP00000011394 | annotation not available (126 aa) |
| | ENSMFAP00000011563 | annotation not available (136 aa) |
| | POLR2C | DNA-directed RNA polymerase II subunit RPB3. (275 aa) |
| | H2AJ | Histone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (129 aa) |
| | GTF2F2 | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa) |
| | H3C1 | H3 clustered histone 1. (136 aa) |
| | LOC102130997 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ENSMFAP00000012034 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1464 aa) |
| | ENSMFAP00000012162 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMFAP00000012416 | annotation not available (136 aa) |
| | NRIP1 | Nuclear receptor interacting protein 1. (1155 aa) |
| | ENSMFAP00000012784 | annotation not available (136 aa) |
| | AGO2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (881 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | DDX5 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa) |
| | G8F2Z2_MACFA | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMFAP00000013484 | Histone H4. (103 aa) |
| | LOC102146894 | Histone domain-containing protein. (136 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMFAP00000014199 | HATPase_c domain-containing protein. (307 aa) |
| | HIST2H2BE | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | G8F5U3_MACFA | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ENSMFAP00000014622 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMFAP00000014776 | annotation not available (136 aa) |
| | ENSMFAP00000014826 | annotation not available (136 aa) |
| | ENSMFAP00000015048 | annotation not available (136 aa) |
| | ENSMFAP00000015065 | Histone H4. (103 aa) |
| | ENSMFAP00000015112 | annotation not available (126 aa) |
| | ENSMFAP00000015119 | Histone H4. (103 aa) |
| | ENSMFAP00000015138 | Histone H4. (103 aa) |
| | ENSMFAP00000015196 | Histone H4. (103 aa) |
| | POLR2K | Uncharacterized protein. (58 aa) |
| | STAG2 | Stromal antigen 2. (1268 aa) |
| | TFF1 | Trefoil factor 1. (84 aa) |
| | TBP | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase [...] (326 aa) |
| | ENSMFAP00000016154 | CS domain-containing protein. (155 aa) |
| | CHD1 | Chromodomain helicase DNA binding protein 1. (1712 aa) |
| | POLR2D | RNA polymerase II subunit D. (142 aa) |
| | KANK4 | KN motif and ankyrin repeat domains 4. (993 aa) |
| | ENSMFAP00000018412 | HATPase_c domain-containing protein. (644 aa) |
| | GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (601 aa) |
| | KANK3 | KN motif and ankyrin repeat domains 3. (834 aa) |
| | RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa) |
| | ENSMFAP00000020443 | Rad21_Rec8 domain-containing protein. (521 aa) |
| | ENSMFAP00000020929 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa) |
| | AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa) |
| | H3F3B | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | KAT2B | Lysine acetyltransferase 2B. (731 aa) |
| | ENSMFAP00000022290 | Histone domain-containing protein. (113 aa) |
| | PRMT1 | Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa) |
| | CITED1 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa) |
| | ENSMFAP00000025317 | Hist_deacetyl domain-containing protein. (258 aa) |
| | GREB1 | Growth regulating estrogen receptor binding 1. (1949 aa) |
| | ENSMFAP00000026020 | Uncharacterized protein. (300 aa) |
| | TGFA | Transforming growth factor alpha. (166 aa) |
| | PRMT8 | Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa) |
| | TFF3 | Trefoil factor 3. (94 aa) |
| | H3F3A | annotation not available (136 aa) |
| | SP1 | Sp1 transcription factor. (786 aa) |
| | POLR2J3 | Uncharacterized protein. (266 aa) |
| | PTGES3 | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway; Belongs to the p23/wos2 family. (162 aa) |
| | ZC3H12C | Zinc finger CCCH-type containing 12C. (884 aa) |
| | ZC3H12B | Zinc finger CCCH-type containing 12B. (836 aa) |
| | CXXC5 | CXXC-type domain-containing protein. (324 aa) |
| | POLR2B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1308 aa) |
| | CCNT1 | Cyclin T1; Belongs to the cyclin family. (728 aa) |
| | PGR | Progesterone receptor. (936 aa) |
| | GATA3 | GATA binding protein 3. (444 aa) |
| | LOC102133669 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | C11orf88 | Chromosome 11 open reading frame 88. (197 aa) |
| | CARM1 | Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (593 aa) |
| | KANK1 | KN motif and ankyrin repeat domains 1. (1352 aa) |
| | NCOA3 | Nuclear receptor coactivator. (1420 aa) |
| | GREB1L | GREB1 like retinoic acid receptor coactivator. (1924 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (831 aa) |
| | POU2F1 | POU domain protein. (766 aa) |
| | POLR2E | Uncharacterized protein. (210 aa) |
| | KDM4B | Lysine demethylase 4B. (1130 aa) |
| | AGO1 | Argonaute RISC component 1; Belongs to the argonaute family. (857 aa) |
| | GTF2F1 | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | ENSMFAP00000034298 | Histone H3; Belongs to the histone H3 family. (141 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (782 aa) |
| | TNRC6B | Trinucleotide repeat containing adaptor 6B. (1823 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1233 aa) |
| | ZC3H12D | Zinc finger CCCH-type containing 12D. (526 aa) |
| | CDK9 | Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa) |
| | TRPS1 | Transcriptional repressor GATA binding 1. (1294 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | ENSMFAP00000036233 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (104 aa) |
| | GTF2A2 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa) |
| | STAG1 | Stromal antigen 1. (1258 aa) |
| | ENSMFAP00000037561 | Uncharacterized protein. (115 aa) |
| | FOSB | FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa) |
| | POLR2H | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa) |
| | HSP90AB1 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa) |
| | ENSMFAP00000038713 | CS domain-containing protein. (154 aa) |
| | KANK2 | KN motif and ankyrin repeat domains 2. (851 aa) |
| | ENSMFAP00000039407 | Importin subunit alpha; Functions in nuclear protein import. (446 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa) |
| | NCOA1 | Nuclear receptor coactivator 1. (1534 aa) |
| | ZNF217 | Zinc finger protein 217. (1049 aa) |
| | H2BW2 | H2B histone family member M; Belongs to the histone H2B family. (153 aa) |
| | CXCL12 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa) |
| | ENSMFAP00000042475 | Uncharacterized protein. (290 aa) |
| | USF1 | Upstream transcription factor 1. (310 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (165 aa) |
| | TBPL1 | TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). (186 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) |
| | KCTD6 | Potassium channel tetramerization domain containing 6. (237 aa) |
| | ENSMFAP00000043336 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | ENSMFAP00000043498 | Uncharacterized protein. (69 aa) |
| | POLR2J | RNA_pol_L_2 domain-containing protein. (158 aa) |
| | ENSMFAP00000043974 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa) |
| | POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa) |
| | EP300 | E1A binding protein p300. (2414 aa) |
| | FOXA1 | Forkhead box A1. (470 aa) |
| | ENSMFAP00000045422 | Uncharacterized protein. (507 aa) |
| | FKBP4 | Peptidylprolyl isomerase. (459 aa) |
