STRINGSTRING
CREB1 CREB1 FOXG1 FOXG1 CAMK2B CAMK2B HDAC2 HDAC2 LBR LBR HIPK2 HIPK2 NCOR2 NCOR2 MOV10 MOV10 HDAC3 HDAC3 SIN3A SIN3A CAMK2D CAMK2D HDAC1 HDAC1 ENSMFAP00000010148 ENSMFAP00000010148 TBL1X TBL1X TBL1XR1 TBL1XR1 ENSMFAP00000012453 ENSMFAP00000012453 AGO2 AGO2 ENSMFAP00000019629 ENSMFAP00000019629 MECP2 MECP2 GPS2 GPS2 AGO4 AGO4 AGO3 AGO3 CAMK2A CAMK2A ENSMFAP00000025317 ENSMFAP00000025317 HTT HTT CAMK4 CAMK4 AGO1 AGO1 TNRC6B TNRC6B NCOR1 NCOR1 AURKB AURKB ENSMFAP00000043974 ENSMFAP00000043974
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB1cAMP responsive element binding protein 1. (341 aa)
FOXG1Forkhead box G1. (489 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (644 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
LBRLamin B receptor. (615 aa)
HIPK2Homeodomain interacting protein kinase 2. (1196 aa)
NCOR2Nuclear receptor corepressor 2. (2510 aa)
MOV10Mov10 RISC complex RNA helicase. (1003 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
TBL1XF-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. (569 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (543 aa)
ENSMFAP00000012453Hist_deacetyl domain-containing protein. (223 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (881 aa)
ENSMFAP00000019629Uncharacterized protein. (331 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
GPS2G protein pathway suppressor 2. (327 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
HTTHuntingtin. (3118 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1823 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (345 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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