STRINGSTRING
CDKN1A CDKN1A PPARGC1A PPARGC1A POMC POMC FOXG1 FOXG1 CAT CAT G6PC G6PC EP300 EP300 GDF11 GDF11 ENSMFAP00000044279 ENSMFAP00000044279 ENSMFAP00000043974 ENSMFAP00000043974 FASLG FASLG RBL2 RBL2 BCL2L11 BCL2L11 FBXO32 FBXO32 ENSMFAP00000042679 ENSMFAP00000042679 ENSMFAP00000041691 ENSMFAP00000041691 TXNIP TXNIP SOD2 SOD2 SIRT1 SIRT1 NFYA NFYA RETN RETN YWHAG YWHAG CREBBP CREBBP IGFBP1 IGFBP1 ABCA6 ABCA6 AKT2 AKT2 CCNG2 CCNG2 ENSMFAP00000032601 ENSMFAP00000032601 SMAD4 SMAD4 SMAD2 SMAD2 SIRT3 SIRT3 PLXNA4 PLXNA4 TXN TXN HDAC2 HDAC2 FOXO3 FOXO3 ENSMFAP00000000347 ENSMFAP00000000347 NFYB NFYB NFYC NFYC NR3C1 NR3C1 BCL6B BCL6B CITED2 CITED2 PCBP4 PCBP4 DDIT3 DDIT3 FOXO1 FOXO1 ATXN3 ATXN3 ENSMFAP00000025317 ENSMFAP00000025317 GCK GCK PCK1 PCK1 STK11 STK11 YWHAB YWHAB FOXO4 FOXO4 GADD45A GADD45A KAT2B KAT2B KLF4 KLF4 AGRP AGRP AKT3 AKT3 ENSMFAP00000020710 ENSMFAP00000020710 ENSMFAP00000020343 ENSMFAP00000020343 ENSMFAP00000020087 ENSMFAP00000020087 FOXO6 FOXO6 CDKN1B CDKN1B TRIM63 TRIM63 AKT1 AKT1 ENSMFAP00000016088 ENSMFAP00000016088 ENSMFAP00000014215 ENSMFAP00000014215 SREBF1 SREBF1 MSTN MSTN ENSMFAP00000012966 ENSMFAP00000012966 PINK1 PINK1 ENSMFAP00000012434 ENSMFAP00000012434 ENSMFAP00000012107 ENSMFAP00000012107 SFN SFN ENSMFAP00000010148 ENSMFAP00000010148 ENSMFAP00000010018 ENSMFAP00000010018 YWHAQ YWHAQ G7P3Z5_MACFA G7P3Z5_MACFA INS INS HDAC1 HDAC1 BCL6 BCL6 SIN3A SIN3A BTG1 BTG1 SMAD3 SMAD3 YWHAZ YWHAZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
POMCProopiomelanocortin. (265 aa)
FOXG1Forkhead box G1. (489 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (533 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
EP300E1A binding protein p300. (2414 aa)
GDF11Growth differentiation factor 11. (342 aa)
ENSMFAP0000004427914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (212 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
RBL2RB transcriptional corepressor like 2. (1141 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
FBXO32F-box protein 32. (355 aa)
ENSMFAP0000004267914_3_3 domain-containing protein. (92 aa)
ENSMFAP0000004169114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (224 aa)
TXNIPThioredoxin interacting protein. (391 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
SIRT1Sirtuin 1. (743 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
RETNUncharacterized protein. (65 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
CREBBPCREB binding protein. (2442 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
ABCA6ATP binding cassette subfamily A member 6. (1618 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
ENSMFAP00000032601CBFD_NFYB_HMF domain-containing protein. (287 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
PLXNA4Plexin A4. (1894 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
FOXO3Forkhead box O3. (672 aa)
ENSMFAP00000000347CBFD_NFYB_HMF domain-containing protein. (200 aa)
NFYBCBFD_NFYB_HMF domain-containing protein. (208 aa)
NFYCNuclear transcription factor Y subunit gamma. (439 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (778 aa)
BCL6BBCL6B transcription repressor. (474 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
PCBP4Poly(rC) binding protein 4. (406 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
FOXO1Forkhead box O1. (655 aa)
ATXN3Josephin domain-containing protein. (375 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
GCKPhosphotransferase. (480 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
YWHAB14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] (246 aa)
FOXO4Forkhead box O4. (505 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
KAT2BLysine acetyltransferase 2B. (731 aa)
KLF4Testis cDNA clone: QtsA-19426, similar to human Kruppel-like factor 4 (gut) (KLF4). (479 aa)
AGRPAgouti related neuropeptide. (132 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ENSMFAP00000020710Thioredoxin; Belongs to the thioredoxin family. (101 aa)
ENSMFAP00000020343Thioredoxin domain-containing protein. (101 aa)
ENSMFAP00000020087Josephin domain-containing protein. (314 aa)
FOXO6Forkhead box O6. (451 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TRIM63Tripartite motif containing 63. (383 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSMFAP00000016088Uncharacterized protein. (123 aa)
ENSMFAP00000014215Anti_prolifrtn domain-containing protein. (161 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (376 aa)
ENSMFAP00000012966Thioredoxin; Belongs to the thioredoxin family. (105 aa)
PINK1Protein kinase domain-containing protein. (581 aa)
ENSMFAP00000012434Thioredoxin; Belongs to the thioredoxin family. (105 aa)
ENSMFAP0000001210714_3_3 domain-containing protein; Belongs to the 14-3-3 family. (265 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
ENSMFAP0000001001814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
G7P3Z5_MACFAThioredoxin; Belongs to the thioredoxin family. (102 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
BCL6BCL6 transcription repressor. (708 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (257 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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