STRINGSTRING
SMAD2 SMAD2 FOXO4 FOXO4 HDAC2 HDAC2 FOXO3 FOXO3 NR3C1 NR3C1 SMAD3 SMAD3 SIN3A SIN3A HDAC1 HDAC1 INS INS ENSMFAP00000010148 ENSMFAP00000010148 SREBF1 SREBF1 TRIM63 TRIM63 FOXO6 FOXO6 ENSMFAP00000020087 ENSMFAP00000020087 PPARGC1A PPARGC1A POMC POMC CAT CAT G6PC G6PC ENSMFAP00000043974 ENSMFAP00000043974 FBXO32 FBXO32 SOD2 SOD2 RETN RETN IGFBP1 IGFBP1 PLXNA4 PLXNA4 SIRT3 SIRT3 ATXN3 ATXN3 FOXO1 FOXO1 AGRP AGRP PCK1 PCK1 GCK GCK ENSMFAP00000025317 ENSMFAP00000025317 ABCA6 ABCA6 SMAD4 SMAD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FOXO4Forkhead box O4. (505 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
FOXO3Forkhead box O3. (672 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (778 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
TRIM63Tripartite motif containing 63. (383 aa)
FOXO6Forkhead box O6. (451 aa)
ENSMFAP00000020087Josephin domain-containing protein. (314 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
POMCProopiomelanocortin. (265 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (533 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
FBXO32F-box protein 32. (355 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
RETNUncharacterized protein. (65 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
PLXNA4Plexin A4. (1894 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
ATXN3Josephin domain-containing protein. (375 aa)
FOXO1Forkhead box O1. (655 aa)
AGRPAgouti related neuropeptide. (132 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
GCKPhosphotransferase. (480 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
ABCA6ATP binding cassette subfamily A member 6. (1618 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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