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GNAI1 GNAI1 GNAT3 GNAT3 ADORA2B ADORA2B DPEP2 DPEP2 PLCG1 PLCG1 IL6 IL6 ADCY4 ADCY4 CREB1 CREB1 GNG3 GNG3 ADAM17 ADAM17 GNB2 GNB2 ENSMFAP00000042978 ENSMFAP00000042978 GNB1 GNB1 CD3G CD3G ITPR3 ITPR3 GNG10 GNG10 PRKAR2B PRKAR2B GNB4 GNB4 GNAZ GNAZ ADCY3 ADCY3 ADCY1 ADCY1 MAPK14 MAPK14 ADCY7 ADCY7 FGR FGR GNAI3 GNAI3 GNG2 GNG2 GNG7 GNG7 GNB5 GNB5 ADCY5 ADCY5 YES1 YES1 PRKAR1B PRKAR1B IL10 IL10 DPEP3 DPEP3 ITPR1 ITPR1 PLCG2 PLCG2 ENSMFAP00000029969 ENSMFAP00000029969 PRKAR2A PRKAR2A ENSMFAP00000028378 ENSMFAP00000028378 SCART1 SCART1 AHCYL1 AHCYL1 GNG8 GNG8 PRKACB PRKACB GNAS GNAS GNG12 GNG12 LYN LYN ENSMFAP00000022223 ENSMFAP00000022223 HCK HCK ITPR2 ITPR2 GNG11 GNG11 SYK SYK ENSMFAP00000020180 ENSMFAP00000020180 LOC102116394 LOC102116394 GNAI2 GNAI2 SRC SRC DPEP1 DPEP1 PRKAR1A PRKAR1A LOC101925950 LOC101925950 CD163 CD163 PRKACG PRKACG GNG5 GNG5 GNB3 GNB3 CYSLTR1 CYSLTR1 ENSMFAP00000013772 ENSMFAP00000013772 GGT1 GGT1 CYSLTR2 CYSLTR2 PRKACA PRKACA MYH9 MYH9 GNGT2 GNGT2 PLK2 PLK2 FCGR1A FCGR1A CD247 CD247 FYN FYN ADCY6 ADCY6 GNGT1 GNGT1 ADCY8 ADCY8 RHBDF1 RHBDF1 ADCY2 ADCY2 ENSMFAP00000004344 ENSMFAP00000004344 GNG13 GNG13 RHBDF2 RHBDF2 ENSMFAP00000005412 ENSMFAP00000005412 ENSMFAP00000006047 ENSMFAP00000006047 GNG4 GNG4 PRKX PRKX FURIN FURIN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAI1G protein subunit alpha i1. (422 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (394 aa)
DPEP2Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (490 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
GNB2WD_REPEATS_REGION domain-containing protein. (375 aa)
ENSMFAP00000042978G protein gamma domain-containing protein. (63 aa)
GNB1G protein subunit beta 1. (340 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (181 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
GNB4G protein subunit beta 4. (340 aa)
GNAZG protein subunit alpha z. (355 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
FGRTyrosine-protein kinase. (529 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNB5G protein subunit beta 5. (409 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
YES1Tyrosine-protein kinase. (548 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (313 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
DPEP3Dipeptidase 3; Probable metalloprotease which hydrolyzes cystinyl-bis- glycine. May be involved in meiosis (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (513 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ENSMFAP00000029969Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (401 aa)
ENSMFAP00000028378Uncharacterized protein. (317 aa)
SCART1Scavenger receptor family member expressed on T cells 1. (1006 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNASGNAS complex locus. (1023 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LYNTyrosine-protein kinase. (512 aa)
ENSMFAP00000022223Cyclic nucleotide-binding domain-containing protein. (81 aa)
HCKTyrosine-protein kinase HCK; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic p [...] (525 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
SYKTyrosine-protein kinase. (635 aa)
ENSMFAP00000020180Uncharacterized protein. (375 aa)
LOC102116394Uncharacterized protein. (564 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
SRCTyrosine-protein kinase. (542 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (411 aa)
PRKAR1AUncharacterized protein. (381 aa)
LOC101925950Uncharacterized protein. (586 aa)
CD163CD163 molecule. (1153 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNB3G protein subunit beta 3. (340 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
ENSMFAP00000013772Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GGT1Uncharacterized protein. (569 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (332 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
FCGR1AUncharacterized protein. (375 aa)
CD247Uncharacterized protein. (168 aa)
FYNTyrosine-protein kinase. (537 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
RHBDF1Rhomboid 5 homolog 1. (891 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
ENSMFAP00000004344Uncharacterized protein. (293 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
RHBDF2Rhomboid 5 homolog 2. (836 aa)
ENSMFAP00000005412Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSMFAP00000006047Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PRKXProtein kinase X-linked; Belongs to the protein kinase superfamily. (358 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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