STRINGSTRING
ENSMFAP00000001080 ENSMFAP00000001080 FYN FYN CD247 CD247 CRK CRK ENSMFAP00000046103 ENSMFAP00000046103 ABL1 ABL1 VAV1 VAV1 CD3G CD3G ACTR3 ACTR3 ARPC3 ARPC3 ENSMFAP00000041476 ENSMFAP00000041476 MYO9B MYO9B ENSMFAP00000040574 ENSMFAP00000040574 ARPC1B ARPC1B DOCK1 DOCK1 CYFIP2 CYFIP2 ARPC4 ARPC4 CYFIP1 CYFIP1 FGR FGR ENSMFAP00000037181 ENSMFAP00000037181 VAV2 VAV2 YES1 YES1 ARPC1A ARPC1A ARPC5 ARPC5 ENSMFAP00000030863 ENSMFAP00000030863 MYO5A MYO5A MYH2 MYH2 MAPK3 MAPK3 MYO10 MYO10 NCK1 NCK1 MYO1C MYO1C ACTR2 ACTR2 ENSMFAP00000025357 ENSMFAP00000025357 ENSMFAP00000024256 ENSMFAP00000024256 WASL WASL ENSMFAP00000023491 ENSMFAP00000023491 LYN LYN BAIAP2 BAIAP2 BTK BTK ELMO2 ELMO2 ENSMFAP00000022447 ENSMFAP00000022447 HCK HCK SYK SYK CDC42 CDC42 SRC SRC ACTB ACTB ENSMFAP00000017819 ENSMFAP00000017819 ABI1 ABI1 NCKIPSD NCKIPSD VAV3 VAV3 BRK1 BRK1 ACTG1 ACTG1 ARPC2 ARPC2 ENSMFAP00000013586 ENSMFAP00000013586 ENSMFAP00000012835 ENSMFAP00000012835 ACTRT1 ACTRT1 ENSMFAP00000011139 ENSMFAP00000011139 ACTRT2 ACTRT2 ACTL7B ACTL7B ACTL7A ACTL7A WASF3 WASF3 MYH9 MYH9 ENSMFAP00000009163 ENSMFAP00000009163 ENSMFAP00000008755 ENSMFAP00000008755 WASF2 WASF2 NCKAP1L NCKAP1L WIPF3 WIPF3 WIPF1 WIPF1 WAS WAS WASF1 WASF1 ENSMFAP00000004985 ENSMFAP00000004985 NCKAP1 NCKAP1 ELMO1 ELMO1 MAPK1 MAPK1 PTK2 PTK2 WIPF2 WIPF2 ENSMFAP00000002257 ENSMFAP00000002257 GRB2 GRB2 ENSMFAP00000001543 ENSMFAP00000001543
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMFAP00000001080Uncharacterized protein; Belongs to the actin family. (354 aa)
FYNTyrosine-protein kinase. (537 aa)
CD247Uncharacterized protein. (168 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
ENSMFAP00000046103Uncharacterized protein. (225 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (181 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
ENSMFAP00000041476Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (165 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2157 aa)
ENSMFAP00000040574Uncharacterized protein. (130 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (278 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1232 aa)
FGRTyrosine-protein kinase. (529 aa)
ENSMFAP00000037181Uncharacterized protein; Belongs to the actin family. (163 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
YES1Tyrosine-protein kinase. (548 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ENSMFAP00000030863Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (313 aa)
MYO5AMyosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1855 aa)
MYH2Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2071 aa)
NCK1Cytoplasmic protein. (377 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
ENSMFAP00000025357Uncharacterized protein. (136 aa)
ENSMFAP00000024256Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (165 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ENSMFAP00000023491Uncharacterized protein. (185 aa)
LYNTyrosine-protein kinase. (512 aa)
BAIAP2Uncharacterized protein. (552 aa)
BTKTyrosine-protein kinase. (659 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
ENSMFAP00000022447Uncharacterized protein. (345 aa)
HCKTyrosine-protein kinase HCK; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic p [...] (525 aa)
SYKTyrosine-protein kinase. (635 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
SRCTyrosine-protein kinase. (542 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (379 aa)
ENSMFAP00000017819Uncharacterized protein. (185 aa)
ABI1Abl interactor 1. (508 aa)
NCKIPSDNCK interacting protein with SH3 domain. (722 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
BRK1Uncharacterized protein. (75 aa)
ACTG1Uncharacterized protein. (377 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
ENSMFAP00000013586Uncharacterized protein; Belongs to the actin family. (257 aa)
ENSMFAP00000012835Uncharacterized protein. (191 aa)
ACTRT1Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family. (350 aa)
ENSMFAP00000011139Uncharacterized protein. (191 aa)
ACTRT2Actin-related protein T2. (377 aa)
ACTL7BActin-like protein 7B. (415 aa)
ACTL7AActin-like protein 7A; Belongs to the actin family. (435 aa)
WASF3WASP family member 3. (502 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
ENSMFAP00000009163Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (410 aa)
ENSMFAP00000008755Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (153 aa)
WASF2WASP family member 2. (498 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
WIPF3WAS/WASL interacting protein family member 3. (486 aa)
WIPF1WAS/WASL interacting protein family member 1. (510 aa)
WASWASP actin nucleation promoting factor. (503 aa)
WASF1WASP family member 1. (559 aa)
ENSMFAP00000004985Uncharacterized protein. (90 aa)
NCKAP1NCK associated protein 1. (1134 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
WIPF2WAS/WASL interacting protein family member 2. (440 aa)
ENSMFAP00000002257Uncharacterized protein. (68 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
ENSMFAP00000001543Uncharacterized protein. (175 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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