STRINGSTRING
RHOQ RHOQ HDAC2 HDAC2 TGFB1 TGFB1 CCNE2 CCNE2 CCND1 CCND1 FYN FYN PPP2R5E PPP2R5E CASP6 CASP6 MAPK4 MAPK4 CITED2 CITED2 YY1 YY1 CDC25B CDC25B PPP2R5C PPP2R5C TGFB2 TGFB2 ATF2 ATF2 GPX6 GPX6 SOS2 SOS2 CFL2 CFL2 ENSMFAP00000009163 ENSMFAP00000009163 H2BC11 H2BC11 H1-0 H1-0 H2AC7 H2AC7 H2AW H2AW TGFB3 TGFB3 GPX3 GPX3 RHOB RHOB FBXO11 FBXO11 CASP10 CASP10 MYCBP2 MYCBP2 CDC42 CDC42 BBC3 BBC3 GPX1 GPX1 WASL WASL ACTR2 ACTR2 CDK2 CDK2 CDC25A CDC25A CASP7 CASP7 RND3 RND3 GPX7 GPX7 ENSMFAP00000030863 ENSMFAP00000030863 GPX4 GPX4 CASP3 CASP3 NCOA3 NCOA3 GPX5 GPX5 B2M B2M HGF HGF RHOT1 RHOT1 CASP8 CASP8 PRMT3 PRMT3 GPX8 GPX8 RARS2 RARS2 GPX2 GPX2 CREB1 CREB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOQRas homolog family member Q. (205 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
FYNTyrosine-protein kinase. (537 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
CASP6Uncharacterized protein; Belongs to the peptidase C14A family. (293 aa)
MAPK4Mitogen-activated protein kinase 4. (587 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
YY1YY1 transcription factor. (414 aa)
CDC25BCell division cycle 25B. (580 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ENSMFAP00000009163Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (410 aa)
H2BC11Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
H1-0H1 histone family member 0. (194 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
RHOBRas homolog gene family, member B. (196 aa)
FBXO11F-box protein 11. (926 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (519 aa)
MYCBP2MYC binding protein 2. (4751 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
BBC3BCL2 binding component 3. (261 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
CDC25ACell division cycle 25A. (491 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (377 aa)
RND3Rho family GTPase 3. (244 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (184 aa)
ENSMFAP00000030863Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (313 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (233 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
NCOA3Nuclear receptor coactivator. (1420 aa)
GPX5Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. (221 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
RHOT1Ras homolog family member T1. (752 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (579 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (158 aa)
RARS2Arginyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (582 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (150 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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