STRINGSTRING
TFPI2 TFPI2 VWF VWF GLA GLA TFPI TFPI NAGA NAGA TNFAIP3 TNFAIP3 SERPINA1 SERPINA1 CD40LG CD40LG CTLA4 CTLA4 CD4 CD4 SIGLEC1 SIGLEC1 CD55 CD55 LOC102142214 LOC102142214 LOC102131633 LOC102131633
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TFPI2Tissue factor pathway inhibitor. (235 aa)
VWFVon Willebrand factor. (2813 aa)
GLAAlpha-galactosidase. (429 aa)
TFPITissue factor pathway inhibitor. (304 aa)
NAGAAlpha-galactosidase. (411 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in [...] (790 aa)
SERPINA1Serpin family A member 1; Belongs to the serpin family. (418 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1709 aa)
CD55CD55 molecule (Cromer blood group). (541 aa)
LOC102142214Rieske domain-containing protein. (590 aa)
LOC102131633MHC_I-like_Ag-recog domain-containing protein. (245 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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