node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | APP | ENSMFAP00000017983 | ENSMFAP00000007885 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.408 |
ACTB | GAPDH | ENSMFAP00000017983 | ENSMFAP00000004362 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Glyceraldehyde-3-phosphate dehydrogenase. | 0.862 |
ACTB | YWHAZ | ENSMFAP00000017983 | ENSMFAP00000004111 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. | 0.632 |
ADAM10 | ADAM17 | ENSMFAP00000034841 | ENSMFAP00000043554 | ADAM metallopeptidase domain 10. | ADAM metallopeptidase domain 17. | 0.939 |
ADAM10 | APH1A | ENSMFAP00000034841 | ENSMFAP00000007408 | ADAM metallopeptidase domain 10. | Uncharacterized protein. | 0.546 |
ADAM10 | APP | ENSMFAP00000034841 | ENSMFAP00000007885 | ADAM metallopeptidase domain 10. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.820 |
ADAM10 | BACE1 | ENSMFAP00000034841 | ENSMFAP00000016850 | ADAM metallopeptidase domain 10. | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.735 |
ADAM10 | NCSTN | ENSMFAP00000034841 | ENSMFAP00000033979 | ADAM metallopeptidase domain 10. | Ncstrn_small domain-containing protein. | 0.756 |
ADAM10 | PSEN1 | ENSMFAP00000034841 | ENSMFAP00000002389 | ADAM metallopeptidase domain 10. | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.716 |
ADAM10 | PSEN2 | ENSMFAP00000034841 | ENSMFAP00000002554 | ADAM metallopeptidase domain 10. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.711 |
ADAM10 | PSENEN | ENSMFAP00000034841 | ENSMFAP00000007003 | ADAM metallopeptidase domain 10. | Presenilin enhancer, gamma-secretase subunit. | 0.740 |
ADAM17 | ADAM10 | ENSMFAP00000043554 | ENSMFAP00000034841 | ADAM metallopeptidase domain 17. | ADAM metallopeptidase domain 10. | 0.939 |
ADAM17 | APH1A | ENSMFAP00000043554 | ENSMFAP00000007408 | ADAM metallopeptidase domain 17. | Uncharacterized protein. | 0.409 |
ADAM17 | APP | ENSMFAP00000043554 | ENSMFAP00000007885 | ADAM metallopeptidase domain 17. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.528 |
ADAM17 | BACE1 | ENSMFAP00000043554 | ENSMFAP00000016850 | ADAM metallopeptidase domain 17. | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.452 |
ADAM17 | NCSTN | ENSMFAP00000043554 | ENSMFAP00000033979 | ADAM metallopeptidase domain 17. | Ncstrn_small domain-containing protein. | 0.691 |
ADAM17 | PSEN2 | ENSMFAP00000043554 | ENSMFAP00000002554 | ADAM metallopeptidase domain 17. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.564 |
ADAM17 | PSENEN | ENSMFAP00000043554 | ENSMFAP00000007003 | ADAM metallopeptidase domain 17. | Presenilin enhancer, gamma-secretase subunit. | 0.730 |
ADAM9 | APH1A | ENSMFAP00000044355 | ENSMFAP00000007408 | ADAM metallopeptidase domain 9. | Uncharacterized protein. | 0.400 |
ADAM9 | APP | ENSMFAP00000044355 | ENSMFAP00000007885 | ADAM metallopeptidase domain 9. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.467 |