STRINGSTRING
RARA RARA HDAC2 HDAC2 BRD2 BRD2 ENSMFAP00000000815 ENSMFAP00000000815 BRD9 BRD9 CCR2 CCR2 HDAC10 HDAC10 CDA CDA HDAC11 HDAC11 EXT1 EXT1 HDAC3 HDAC3 HDAC1 HDAC1 HIST1H3B HIST1H3B LOC102147067 LOC102147067 ENSMFAP00000010627 ENSMFAP00000010627 LOC102130997 LOC102130997 ENSMFAP00000012034 ENSMFAP00000012034 H3-4 H3-4 ENSMFAP00000012162 ENSMFAP00000012162 G7PFU7_MACFA G7PFU7_MACFA LOC102146894 LOC102146894 TIMP3 TIMP3 G8F5U3_MACFA G8F5U3_MACFA G7PB98_MACFA G7PB98_MACFA HEXIM1 HEXIM1 BRD4 BRD4 CRBN CRBN DNMT3A DNMT3A NSD2 NSD2 CA4 CA4 BRD7 BRD7 H3F3B H3F3B ENSMFAP00000022290 ENSMFAP00000022290 HDAC5 HDAC5 CCL2 CCL2 BRCA1 BRCA1 ENSMFAP00000026148 ENSMFAP00000026148 FLT3 FLT3 BRDT BRDT PIK3CA PIK3CA ENSMFAP00000029118 ENSMFAP00000029118 BRCA2 BRCA2 MZB1 MZB1 MCL1 MCL1 MDM2 MDM2 HDAC8 HDAC8 ENSMFAP00000034298 ENSMFAP00000034298 PIK3C3 PIK3C3 EGFR EGFR BRD3 BRD3 ESR1 ESR1 EZH2 EZH2 DOT1L DOT1L DNMT3B DNMT3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RARARetinoic acid receptor alpha. (462 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
BRD2Uncharacterized protein. (802 aa)
ENSMFAP00000000815Small ubiquitin-related modifier. (121 aa)
BRD9Bromodomain containing 9. (529 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
HDAC10Histone deacetylase 10. (672 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
HDAC11Histone deacetylase 11; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (319 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
HIST1H3BHistone H3; Belongs to the histone H3 family. (136 aa)
LOC102147067Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000010627Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102130997Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000012034Histone H3; Belongs to the histone H3 family. (136 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000012162Histone H3; Belongs to the histone H3 family. (136 aa)
G7PFU7_MACFASmall ubiquitin-related modifier. (101 aa)
LOC102146894Histone domain-containing protein. (136 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (By similarity). (211 aa)
G8F5U3_MACFAHistone H3; Belongs to the histone H3 family. (136 aa)
G7PB98_MACFASmall ubiquitin-related modifier. (95 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (359 aa)
BRD4Bromodomain containing 4. (1359 aa)
CRBNCereblon. (502 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
CA4Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (315 aa)
BRD7Bromodomain containing 7. (652 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
ENSMFAP00000022290Histone domain-containing protein. (113 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
BRCA1Uncharacterized protein. (1884 aa)
ENSMFAP00000026148Small ubiquitin-related modifier. (95 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1028 aa)
BRDTBromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also re [...] (947 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSMFAP00000029118Small ubiquitin-related modifier. (104 aa)
BRCA2BRCA2 DNA repair associated. (3418 aa)
MZB1Marginal zone B and B1 cell specific protein. (188 aa)
MCL1Uncharacterized protein. (350 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)
ENSMFAP00000034298Histone H3; Belongs to the histone H3 family. (141 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
BRD3Bromodomain containing 3. (726 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
EZH2Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] (751 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1562 aa)
DNMT3BDNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (853 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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