STRINGSTRING
GCK GCK FOXA2 FOXA2 ATF4 ATF4 SEC63 SEC63 SSR1 SSR1 ENSMFAP00000043489 ENSMFAP00000043489 ENSMFAP00000042604 ENSMFAP00000042604 CREB3L3 CREB3L3 MTOR MTOR HSPA5 HSPA5 IAPP IAPP TXNIP TXNIP ATF6 ATF6 PLIN3 PLIN3 PKLR PKLR SLC2A2 SLC2A2 RIPK3 RIPK3 DNAJC3 DNAJC3 GLUD2 GLUD2 HSP90B1 HSP90B1 FFAR4 FFAR4 LOC102124370 LOC102124370 ENSMFAP00000029118 ENSMFAP00000029118 DDIT3 DDIT3 NFATC2 NFATC2 ENSMFAP00000027000 ENSMFAP00000027000 CREB3 CREB3 PKM PKM FOXO1 FOXO1 ENSMFAP00000026148 ENSMFAP00000026148 MANF MANF LONP1 LONP1 SYT4 SYT4 IL1B IL1B GIPR GIPR CREB3L2 CREB3L2 ATF5 ATF5 CDKAL1 CDKAL1 THBS1 THBS1 YIPF3 YIPF3 FGF21 FGF21 RPAP2 RPAP2 CREB3L1 CREB3L1 G7PB98_MACFA G7PB98_MACFA G7PFU7_MACFA G7PFU7_MACFA NFATC1 NFATC1 FFAR1 FFAR1 UBL5 UBL5 UBD UBD SENP1 SENP1 YIPF5 YIPF5 XBP1 XBP1 TRIB3 TRIB3 ENSMFAP00000000815 ENSMFAP00000000815 ENSMFAP00000005508 ENSMFAP00000005508
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GCKPhosphotransferase. (480 aa)
FOXA2Forkhead box A2. (457 aa)
ATF4Activating transcription factor 4. (351 aa)
SEC63SEC63 homolog, protein translocation regulator. (760 aa)
SSR1Signal sequence receptor subunit 1. (298 aa)
ENSMFAP00000043489Pyruvate kinase; Belongs to the pyruvate kinase family. (525 aa)
ENSMFAP00000042604Pyruvate kinase; Belongs to the pyruvate kinase family. (455 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (301 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
IAPPIslet amyloid polypeptide. (89 aa)
TXNIPThioredoxin interacting protein. (391 aa)
ATF6Activating transcription factor 6. (669 aa)
PLIN3Perilipin; Belongs to the perilipin family. (434 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
GLUD2Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (534 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (804 aa)
FFAR4Free fatty acid receptor 4; Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega- 3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)- coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates [...] (377 aa)
LOC102124370Perilipin; Belongs to the perilipin family. (445 aa)
ENSMFAP00000029118Small ubiquitin-related modifier. (104 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
ENSMFAP00000027000Pyruvate kinase; Belongs to the pyruvate kinase family. (142 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
FOXO1Forkhead box O1. (655 aa)
ENSMFAP00000026148Small ubiquitin-related modifier. (95 aa)
MANFMesencephalic astrocyte derived neurotrophic factor. (182 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (961 aa)
SYT4Synaptotagmin 4. (425 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ATF5Activating transcription factor 5. (282 aa)
CDKAL1CDK5 regulatory subunit associated protein 1 like 1. (576 aa)
THBS1Thrombospondin 1. (1173 aa)
YIPF3Yip1 domain family member 3. (350 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
RPAP2RNA polymerase II associated protein 2. (612 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
G7PB98_MACFASmall ubiquitin-related modifier. (95 aa)
G7PFU7_MACFASmall ubiquitin-related modifier. (101 aa)
NFATC1Nuclear factor of activated T cells 1. (812 aa)
FFAR1Free fatty acid receptor 1; G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular c [...] (300 aa)
UBL5Testis cDNA, clone: QtsA-15893, similar to human ubiquitin-like 5 (UBL5). (73 aa)
UBDUbiquitin D. (165 aa)
SENP1ULP_PROTEASE domain-containing protein. (645 aa)
YIPF5Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi. (257 aa)
XBP1BZIP domain-containing protein. (380 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
ENSMFAP00000000815Small ubiquitin-related modifier. (121 aa)
ENSMFAP00000005508Pyruvate kinase; Belongs to the pyruvate kinase family. (332 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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