STRINGSTRING
IL17A IL17A SHANK3 SHANK3 FOXP1 FOXP1 MTOR MTOR EIF4E EIF4E KCTD13 KCTD13 CNTNAP2 CNTNAP2 PDE10A PDE10A NRXN1 NRXN1 NLGN4Y NLGN4Y SYP SYP CBLN1 CBLN1 STMN2 STMN2 NRXN2 NRXN2 NLGN1 NLGN1 NLGN2 NLGN2 NTRK2 NTRK2 KMO KMO POGZ POGZ PVALB PVALB GRID2 GRID2 IL2 IL2 ARID1B ARID1B TSC2 TSC2 MECP2 MECP2 ANK2 ANK2 SHANK2 SHANK2 NRXN3 NRXN3 CDH8 CDH8 FMR1 FMR1 CHD8 CHD8 GRM1 GRM1 ALDH1A2 ALDH1A2 HOMER1 HOMER1 OXTR OXTR UBE3A UBE3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL17AInterleukin 17A. (155 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1596 aa)
FOXP1Forkhead box P1. (693 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
EIF4EEukaryotic translation initiation factor 4E. (247 aa)
KCTD13Potassium channel tetramerization domain containing 13. (329 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
PDE10APhosphodiesterase. (856 aa)
NRXN1Neurexin 1. (1507 aa)
NLGN4YNeuroligin 4 Y-linked. (873 aa)
SYPSynaptophysin. (313 aa)
CBLN1Cerebellin 1 precursor. (193 aa)
STMN2Stathmin; Belongs to the stathmin family. (190 aa)
NRXN2Neurexin 2. (1713 aa)
NLGN1Neuroligin 1. (823 aa)
NLGN2Neuroligin 2. (849 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (458 aa)
POGZPogo transposable element derived with ZNF domain. (1418 aa)
PVALBParvalbumin; Belongs to the parvalbumin family. (110 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
ARID1BAT-rich interaction domain 1B. (2295 aa)
TSC2TSC complex subunit 2. (1807 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
ANK2Ankyrin 2. (3938 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1742 aa)
NRXN3Neurexin 3. (1664 aa)
CDH8Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (744 aa)
FMR1Fragile X mental retardation 1. (632 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2589 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (540 aa)
HOMER1Homer scaffold protein 1. (358 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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