STRINGSTRING
STAT1 STAT1 CD80 CD80 IRF3 IRF3 TBK1 TBK1 CCL5 CCL5 IFNB1 IFNB1 HDAC9 HDAC9 PFN2 PFN2 HDAC7 HDAC7 TRAF3 TRAF3 CUL4A CUL4A TLR7 TLR7 DDB1 DDB1 STAT2 STAT2 HDAC4 HDAC4 CD19 CD19 TRIM25 TRIM25 CUL1 CUL1 TLR3 TLR3 TRAF6 TRAF6 RBX1 RBX1 RHOA RHOA CD86 CD86 OAS2 OAS2 OAS1 OAS1 SKP1 SKP1 OAS3 OAS3 IL6 IL6 HDAC5 HDAC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT1Signal transducer and activator of transcription. (758 aa)
CD80CD80 molecule. (288 aa)
IRF3Interferon regulatory factor 3. (422 aa)
TBK1TANK binding kinase 1. (729 aa)
CCL5C-C motif chemokine. (91 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (187 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
PFN2Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). (188 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1008 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
CD19CD19 molecule. (557 aa)
TRIM25Tripartite motif containing 25. (630 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RBX1RING-box protein 1. (108 aa)
RHOAUncharacterized protein. (141 aa)
CD86CD86 molecule. (329 aa)
OAS22'-5'-oligoadenylate synthetase 2. (687 aa)
OAS12'-5'-oligoadenylate synthetase 1. (488 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (167 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1088 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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