STRINGSTRING
SNX27 SNX27 PARD6A PARD6A SHROOM2 SHROOM2 SHANK1 SHANK1 RIMS2 RIMS2 PREX2 PREX2 APBA1 APBA1 SNTB1 SNTB1 SHANK2 SHANK2 LRRC7 LRRC7 DVL3 DVL3 PARD6G PARD6G SDCBP2 SDCBP2 ARHGAP23 ARHGAP23 DLG1 DLG1 DEPTOR DEPTOR TAX1BP3 TAX1BP3 CNKSR3 CNKSR3 SYNJ2BP SYNJ2BP STXBP4 STXBP4 APBA2 APBA2 FRMPD4 FRMPD4 PTPN13 PTPN13 TJP2 TJP2 ARHGEF12 ARHGEF12 PDZD4 PDZD4 ENSMFAP00000017173 ENSMFAP00000017173 CNKSR1 CNKSR1 IL16 IL16 DLG5 DLG5 DLG4 DLG4 MAGI1 MAGI1 PDLIM2 PDLIM2 LOC102145105 LOC102145105 MPDZ MPDZ GOPC GOPC RHPN1 RHPN1 ERBIN ERBIN PDZD2 PDZD2 FRMPD1 FRMPD1 GRID2IP GRID2IP TIAM1 TIAM1 PDLIM3 PDLIM3 ENSMFAP00000006504 ENSMFAP00000006504 USH1C USH1C PARD3 PARD3 HTRA3 HTRA3 PDZD3 PDZD3 PCLO PCLO MAGI2 MAGI2 PDZRN3 PDZRN3 NOS1 NOS1 TIAM2 TIAM2 PTPN3 PTPN3 PARD6B PARD6B MPP5 MPP5 LMO7 LMO7 PDLIM4 PDLIM4 PDZK1 PDZK1 MPP6 MPP6 FRMPD2 FRMPD2 INTU INTU PREX1 PREX1 SHANK3 SHANK3 LNX1 LNX1 RADIL RADIL MAST4 MAST4 MAST3 MAST3 DVL2 DVL2 RGS12 RGS12 PDLIM7 PDLIM7 SNTA1 SNTA1 SIPA1L2 SIPA1L2 FRMPD3 FRMPD3 LIN7A LIN7A MAGI3 MAGI3 PPP1R9B PPP1R9B DLG3 DLG3 GRASP GRASP ARHGAP21 ARHGAP21 MAST1 MAST1 RGS3 RGS3 MPP1 MPP1 LIN7B LIN7B ARHGEF11 ARHGEF11 SIPA1L1 SIPA1L1 MPP4 MPP4 PDZD9 PDZD9 SDCBP SDCBP CNKSR2 CNKSR2 SIPA1L3 SIPA1L3 PDZD7 PDZD7 MPP2 MPP2 SYNPO2 SYNPO2 AHNAK AHNAK GRIP1 GRIP1 RIMS1 RIMS1 CARD14 CARD14 PPP1R9A PPP1R9A SNTG1 SNTG1 SNTG2 SNTG2 MPP3 MPP3 PICK1 PICK1 WHRN WHRN TJP1 TJP1 MYO18A MYO18A SHROOM3 SHROOM3 PDZD11 PDZD11 PSMD9 PSMD9 PDZD8 PDZD8 PDZRN4 PDZRN4 PTPN4 PTPN4 GIPC2 GIPC2 LIMK2 LIMK2 GIPC1 GIPC1 SCRIB SCRIB SHROOM4 SHROOM4 LIMK1 LIMK1 HTRA4 HTRA4 LIN7C LIN7C GORASP2 GORASP2 LNX2 LNX2 AFDN AFDN MPP7 MPP7 PATJ PATJ HTRA1 HTRA1 SLC9A3R2 SLC9A3R2 PRX PRX SYNPO2L SYNPO2L ENSMFAP00000025331 ENSMFAP00000025331 PARD3B PARD3B APBA3 APBA3 RAPGEF2 RAPGEF2 SLC9A3R1 SLC9A3R1 CYTIP CYTIP DLG2 DLG2 RHPN2 RHPN2 GIPC3 GIPC3 CASK CASK GRIP2 GRIP2 SIPA1 SIPA1 MAGIX MAGIX DVL1 DVL1 RAPGEF6 RAPGEF6 HTRA2 HTRA2 MAST2 MAST2 LDB3 LDB3 PDLIM1 PDLIM1 PDLIM5 PDLIM5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNX27Sorting nexin 27. (541 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
SHROOM2Shroom family member 2. (1612 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (2171 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1367 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1606 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (840 aa)
SNTB1Syntrophin beta 1. (538 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1742 aa)
LRRC7Leucine rich repeat containing 7. (1542 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
SDCBP2Syndecan binding protein 2. (292 aa)
ARHGAP23Rho GTPase activating protein 23. (1438 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
DEPTORDEP domain containing MTOR interacting protein. (409 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
CNKSR3CNKSR family member 3. (555 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
STXBP4Syntaxin binding protein 4. (555 aa)
APBA2Amyloid beta precursor protein binding family A member 2. (749 aa)
FRMPD4FERM and PDZ domain containing 4. (1352 aa)
PTPN13Protein tyrosine phosphatase non-receptor type 13. (2492 aa)
TJP2Uncharacterized protein; Belongs to the MAGUK family. (1247 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
PDZD4PDZ domain containing 4. (775 aa)
ENSMFAP00000017173PDZ domain-containing protein. (255 aa)
CNKSR1Connector enhancer of kinase suppressor of Ras 1. (713 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (By similarity). (1331 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1905 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1462 aa)
PDLIM2PDZ and LIM domain protein 2; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). (602 aa)
LOC102145105Uncharacterized protein. (971 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2084 aa)
GOPCPDZ domain-containing protein. (462 aa)
RHPN1Rhophilin Rho GTPase binding protein 1. (669 aa)
ERBINErbb2 interacting protein. (1418 aa)
PDZD2PDZ domain containing 2. (2792 aa)
FRMPD1FERM and PDZ domain containing 1. (1578 aa)
GRID2IPGrid2 interacting protein. (1156 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
PDLIM3PDZ and LIM domain 3. (364 aa)
ENSMFAP00000006504PDZ domain-containing protein. (285 aa)
USH1CUSH1 protein network component harmonin. (899 aa)
PARD3Par-3 family cell polarity regulator. (1325 aa)
HTRA3HtrA serine peptidase 3. (453 aa)
PDZD3PDZ domain containing 3. (505 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5181 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1283 aa)
PDZRN3PDZ domain containing ring finger 3. (1066 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1725 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (913 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
LMO7LIM domain 7. (1670 aa)
PDLIM4PDZ and LIM domain 4. (329 aa)
PDZK1PDZ domain containing 1. (519 aa)
MPP6Uncharacterized protein; Belongs to the MAGUK family. (582 aa)
FRMPD2FERM and PDZ domain containing 2. (1310 aa)
INTUInturned planar cell polarity protein. (942 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1661 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1596 aa)
LNX1Ligand of numb-protein X 1. (727 aa)
RADILRap associating with DIL domain. (1071 aa)
MAST4Microtubule associated serine/threonine kinase family member 4. (2518 aa)
MAST3Microtubule associated serine/threonine kinase 3. (1311 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
RGS12Regulator of G protein signaling 12. (1447 aa)
PDLIM7PDZ and LIM domain 7. (441 aa)
SNTA1Syntrophin alpha 1. (505 aa)
SIPA1L2Signal induced proliferation associated 1 like 2. (1722 aa)
FRMPD3FERM and PDZ domain containing 3. (1810 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1482 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (818 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (863 aa)
GRASPGeneral receptor for phosphoinositides 1 associated scaffold protein. (395 aa)
ARHGAP21Rho GTPase activating protein 21. (1958 aa)
MAST1Microtubule associated serine/threonine kinase 1. (1571 aa)
RGS3Regulator of G protein signaling 3. (916 aa)
MPP1Membrane palmitoylated protein 1; Belongs to the MAGUK family. (466 aa)
LIN7BProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1573 aa)
SIPA1L1Signal induced proliferation associated 1 like 1. (1804 aa)
MPP4Membrane palmitoylated protein 4; Belongs to the MAGUK family. (636 aa)
PDZD9PDZ domain-containing protein 9. (264 aa)
SDCBPUncharacterized protein. (324 aa)
CNKSR2Connector enhancer of kinase suppressor of Ras 2. (1034 aa)
SIPA1L3Signal induced proliferation associated 1 like 3. (1777 aa)
PDZD7PDZ domain containing 7. (1030 aa)
MPP2Membrane palmitoylated protein 2; Belongs to the MAGUK family. (537 aa)
SYNPO2Synaptopodin 2. (1261 aa)
AHNAKAHNAK nucleoprotein. (5758 aa)
GRIP1Glutamate receptor interacting protein 1. (1120 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1692 aa)
CARD14Caspase recruitment domain family member 14. (995 aa)
PPP1R9AProtein phosphatase 1 regulatory subunit 9A. (1371 aa)
SNTG1Syntrophin gamma 1. (517 aa)
SNTG2Syntrophin gamma 2. (539 aa)
MPP3Membrane palmitoylated protein 3; Belongs to the MAGUK family. (619 aa)
PICK1PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] (415 aa)
WHRNWhirlin. (907 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1767 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2054 aa)
SHROOM3Shroom family member 3. (1996 aa)
PDZD11PDZ domain-containing protein. (140 aa)
PSMD9PDZ domain-containing protein. (223 aa)
PDZD8PDZ domain containing 8. (1154 aa)
PDZRN4PDZ domain containing ring finger 4. (777 aa)
PTPN4Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa)
GIPC2GIPC PDZ domain containing family member 2. (315 aa)
LIMK2LIM domain kinase 2. (638 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
SCRIBScribble planar cell polarity protein. (1662 aa)
SHROOM4Shroom family member 4. (1499 aa)
LIMK1LIM domain kinase 1. (677 aa)
HTRA4HtrA serine peptidase 4. (476 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
GORASP2Golgi reassembly stacking protein 2. (452 aa)
LNX2Ligand of numb-protein X 2. (690 aa)
AFDNAfadin, adherens junction formation factor. (1781 aa)
MPP7Membrane palmitoylated protein 7; Belongs to the MAGUK family. (576 aa)
PATJUncharacterized protein. (568 aa)
HTRA1HtrA serine peptidase 1. (481 aa)
SLC9A3R2SLC9A3 regulator 2. (311 aa)
PRXPeriaxin. (1419 aa)
SYNPO2LSynaptopodin 2 like. (979 aa)
ENSMFAP00000025331Uncharacterized protein. (259 aa)
PARD3BPar-3 family cell polarity regulator beta. (1204 aa)
APBA3Amyloid beta precursor protein binding family A member 3. (575 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1701 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatoz [...] (358 aa)
CYTIPCytohesin 1 interacting protein. (359 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
RHPN2Rhophilin Rho GTPase binding protein 2. (610 aa)
GIPC3GIPC PDZ domain containing family member 3. (312 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
GRIP2Glutamate receptor interacting protein 2. (1143 aa)
SIPA1Signal-induced proliferation-associated 1. (1042 aa)
MAGIXMAGI family member, X-linked. (332 aa)
DVL1Dishevelled segment polarity protein 1. (673 aa)
RAPGEF6Uncharacterized protein. (1609 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1795 aa)
LDB3LIM domain binding 3. (732 aa)
PDLIM1PDZ and LIM domain 1. (330 aa)
PDLIM5PDZ and LIM domain 5. (625 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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