node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | ESR1 | ENSMFAP00000031008 | ENSMFAP00000043221 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.713 |
AR | ESR2 | ENSMFAP00000031008 | ENSMFAP00000031270 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Estrogen receptor 2. | 0.450 |
AR | NR3C1 | ENSMFAP00000031008 | ENSMFAP00000000850 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Nuclear receptor subfamily 3 group C member 1. | 0.633 |
AR | NR3C2 | ENSMFAP00000031008 | ENSMFAP00000006794 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Nuclear receptor subfamily 3 group C member 2. | 0.647 |
AR | PGR | ENSMFAP00000031008 | ENSMFAP00000030596 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Progesterone receptor. | 0.674 |
ENSMFAP00000021707 | ESRRB | ENSMFAP00000021707 | ENSMFAP00000009231 | Nuclear receptor domain-containing protein. | Estrogen related receptor beta. | 0.484 |
ENSMFAP00000021707 | ESRRG | ENSMFAP00000021707 | ENSMFAP00000009972 | Nuclear receptor domain-containing protein. | Estrogen related receptor gamma. | 0.597 |
ENSMFAP00000021707 | PPARG | ENSMFAP00000021707 | ENSMFAP00000035941 | Nuclear receptor domain-containing protein. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.434 |
ESR1 | AR | ENSMFAP00000043221 | ENSMFAP00000031008 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 0.713 |
ESR1 | ESR2 | ENSMFAP00000043221 | ENSMFAP00000031270 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Estrogen receptor 2. | 0.994 |
ESR1 | NR3C1 | ENSMFAP00000043221 | ENSMFAP00000000850 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor subfamily 3 group C member 1. | 0.465 |
ESR1 | NR5A1 | ENSMFAP00000043221 | ENSMFAP00000025487 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor subfamily 5 group A member 1. | 0.490 |
ESR1 | NR5A2 | ENSMFAP00000043221 | ENSMFAP00000007884 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor subfamily 5 group A member 2. | 0.489 |
ESR1 | PGR | ENSMFAP00000043221 | ENSMFAP00000030596 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Progesterone receptor. | 0.957 |
ESR1 | PPARG | ENSMFAP00000043221 | ENSMFAP00000035941 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.531 |
ESR2 | AR | ENSMFAP00000031270 | ENSMFAP00000031008 | Estrogen receptor 2. | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 0.450 |
ESR2 | ESR1 | ENSMFAP00000031270 | ENSMFAP00000043221 | Estrogen receptor 2. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.994 |
ESR2 | NR5A1 | ENSMFAP00000031270 | ENSMFAP00000025487 | Estrogen receptor 2. | Nuclear receptor subfamily 5 group A member 1. | 0.453 |
ESR2 | NR5A2 | ENSMFAP00000031270 | ENSMFAP00000007884 | Estrogen receptor 2. | Nuclear receptor subfamily 5 group A member 2. | 0.453 |
ESR2 | PGR | ENSMFAP00000031270 | ENSMFAP00000030596 | Estrogen receptor 2. | Progesterone receptor. | 0.853 |