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| | SNW1 | SNW domain containing 1. (571 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (464 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (825 aa) |
| | SNRPD2 | Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa) |
| | PRPF6 | Pre-mRNA processing factor 6. (941 aa) |
| | SNRPD3 | Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa) |
| | RP9 | RP9 pre-mRNA splicing factor. (221 aa) |
| | PLRG1 | Pleiotropic regulator 1. (514 aa) |
| | SRSF7 | Uncharacterized protein. (235 aa) |
| | SLU7 | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. (586 aa) |
| | PPIE | Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa) |
| | CDC40 | Cell division cycle 40. (579 aa) |
| | SRSF5 | Serine and arginine rich splicing factor 5. (272 aa) |
| | HNRNPCL1 | RRM domain-containing protein. (220 aa) |
| | SMNDC1 | Tudor domain-containing protein. (238 aa) |
| | SART1 | Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (800 aa) |
| | SF3A2 | Splicing factor 3a subunit 2. (464 aa) |
| | ZMAT2 | Zinc finger matrin-type 2. (199 aa) |
| | TXNL4A | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa) |
| | ALYREF | Aly/REF export factor. (257 aa) |
| | PRPF31 | Pre-mRNA processing factor 31. (499 aa) |
| | NCBP2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa) |
| | LSM2 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa) |
| | CDC5L | Cell division cycle 5 like. (802 aa) |
| | HNRNPA3 | Heterogeneous nuclear ribonucleoprotein A3. (378 aa) |
| | ENSMFAP00000010363 | Uncharacterized protein. (192 aa) |
| | PRPF38B | Pre-mRNA processing factor 38B. (546 aa) |
| | SNRPA1 | U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. (255 aa) |
| | SNRPG-2 | Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa) |
| | SRSF8 | Serine and arginine rich splicing factor 8. (287 aa) |
| | DDX5 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa) |
| | SF3B5 | Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa) |
| | XAB2 | XPA binding protein 2. (855 aa) |
| | PQBP1 | Polyglutamine binding protein 1. (265 aa) |
| | ENSMFAP00000014202 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (571 aa) |
| | SNRPC-2 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (159 aa) |
| | ENSMFAP00000014996 | Uncharacterized protein. (308 aa) |
| | AQR | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1480 aa) |
| | NCBP1 | Nuclear cap binding protein subunit 1. (790 aa) |
| | SNU13 | NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. (158 aa) |
| | U2SURP | U2 snRNP associated SURP domain containing. (1029 aa) |
| | LSM4 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa) |
| | SNRPB2 | Small nuclear ribonucleoprotein polypeptide B2. (225 aa) |
| | SNRNP40 | WD_REPEATS_REGION domain-containing protein. (401 aa) |
| | DDX42 | DEAD-box helicase 42. (937 aa) |
| | ENSMFAP00000016862 | Uncharacterized protein. (372 aa) |
| | SF3A1 | Splicing factor 3a subunit 1. (793 aa) |
| | DHX38 | DEAH-box helicase 38. (1234 aa) |
| | MAGOH | Mago homolog, exon junction complex subunit. (146 aa) |
| | RBMX | RNA-binding motif protein, X chromosome, N-terminally processed; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the suprasplic [...] (391 aa) |
| | LSM6 | LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa) |
| | CHERP | Calcium homeostasis endoplasmic reticulum protein. (927 aa) |
| | SNRPF | Sm domain-containing protein. (127 aa) |
| | RBM17 | RNA binding motif protein 17. (401 aa) |
| | BUD31 | BUD31 homolog. (144 aa) |
| | PRPF40B | Pre-mRNA processing factor 40 homolog B. (892 aa) |
| | LSM8 | U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa) |
| | WBP11 | WW domain binding protein 11. (641 aa) |
| | HSPA2 | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (641 aa) |
| | SF3A3 | Matrin-type domain-containing protein. (504 aa) |
| | TRA2A | Transformer 2 alpha homolog. (282 aa) |
| | PUF60 | Poly(U) binding splicing factor 60. (559 aa) |
| | BCAS2 | BCAS2, pre-mRNA processing factor. (225 aa) |
| | CWC15 | CWC15 spliceosome associated protein homolog. (229 aa) |
| | ACIN1 | Apoptotic chromatin condensation inducer 1. (1340 aa) |
| | LSM7 | LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa) |
| | DDX46 | DEAD-box helicase 46. (1032 aa) |
| | DHX8 | DEAH-box helicase 8. (1222 aa) |
| | TCERG1 | Transcription elongation regulator 1. (1113 aa) |
| | RBM8A | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa) |
| | SF3B3 | Splicing factor 3b subunit 3. (1217 aa) |
| | SRSF2 | Testis cDNA, clone: QtsA-15801, similar to human splicing factor, arginine/serine-rich 2 (SFRS2). (221 aa) |
| | SNRPA | Small nuclear ribonucleoprotein polypeptide A. (282 aa) |
| | SRSF4 | Serine and arginine rich splicing factor 4. (494 aa) |
| | SYF2 | SYF2 pre-mRNA splicing factor. (243 aa) |
| | SNRPD1 | Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (119 aa) |
| | SF3B4 | Splicing factor 3b subunit 4. (424 aa) |
| | THOC2 | THO complex 2. (1593 aa) |
| | TRA2B | RRM domain-containing protein. (288 aa) |
| | EFTUD2 | Elongation factor Tu GTP binding domain containing 2. (972 aa) |
| | SF3B6 | Splicing factor 3b subunit 6. (125 aa) |
| | SRSF6 | Serine and arginine rich splicing factor 6. (343 aa) |
| | ISY1 | Uncharacterized protein. (285 aa) |
| | PHF5A | PHD finger protein 5A. (110 aa) |
| | LSM3 | U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa) |
| | SF3B2 | Splicing factor 3b subunit 2. (896 aa) |
| | DHX16 | DEAH-box helicase 16. (1044 aa) |
| | DHX15 | DEAH-box helicase 15. (795 aa) |
| | RBM22 | Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses; Belongs to the SLT11 family. (420 aa) |
| | ENSMFAP00000035649 | Uncharacterized protein. (298 aa) |
| | DDX39B | ATP-dependent RNA helicase UAP56/SUB2. (428 aa) |
| | PPIH | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (177 aa) |
| | THOC3 | THO complex 3. (351 aa) |
| | U2AF1L4 | Uncharacterized protein. (220 aa) |
| | LSM5 | U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa) |
| | PRPF40A | Pre-mRNA processing factor 40 homolog A. (930 aa) |
| | HSPA8 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa) |
| | DDX23 | DEAD-box helicase 23. (820 aa) |
| | SNRPB | Small nuclear ribonucleoprotein polypeptides B and B1. (330 aa) |
| | SRSF10 | RRM domain-containing protein. (262 aa) |
| | PPIL1 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa) |
| | USP39 | Ubiquitin specific peptidase 39. (565 aa) |
| | THOC1 | THO complex 1. (660 aa) |
| | SNRNP70 | Small nuclear ribonucleoprotein U1 subunit 70. (437 aa) |
| | PRPF3 | Pre-mRNA processing factor 3. (683 aa) |
| | SNRPE | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (92 aa) |
| | SRSF1 | Uncharacterized protein. (253 aa) |
| | RBM25 | RNA binding motif protein 25. (843 aa) |
| | PRPF8 | Pre-mRNA processing factor 8. (2339 aa) |
| | U2AF2 | U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (475 aa) |
| | SRSF3 | Serine and arginine rich splicing factor 3. (164 aa) |
| | CTNNBL1 | DUF1716 domain-containing protein. (563 aa) |
| | SRSF9 | Serine and arginine rich splicing factor 9. (187 aa) |
| | PRPF4 | Pre-mRNA processing factor 4. (543 aa) |
| | PRPF38A | Pre-mRNA-splicing factor 38A; Involved in pre-mRNA splicing as a component of the spliceosome. (312 aa) |
| | SNRNP200 | Small nuclear ribonucleoprotein U5 subunit 200. (2136 aa) |
| | HSPA1L | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (643 aa) |
| | HNRNPM | Heterogeneous nuclear ribonucleoprotein M. (730 aa) |
| | PRPF18 | Pre-mRNA processing factor 18. (351 aa) |
