STRINGSTRING
PDGFD PDGFD CACNA1S CACNA1S CAMK1 CAMK1 PTGER3 PTGER3 ORAI1 ORAI1 PLCB4 PLCB4 ENSMFAP00000001843 ENSMFAP00000001843 EDNRA EDNRA ORAI3 ORAI3 MYLK MYLK TACR2 TACR2 CASQ1 CASQ1 OXTR OXTR SLC8A2 SLC8A2 AVPR1B AVPR1B CD38 CD38 ADCY8 ADCY8 CACNA1E CACNA1E RYR2 RYR2 PDGFRB PDGFRB ADCY2 ADCY2 MCOLN1 MCOLN1 NOS3 NOS3 TBXA2R TBXA2R MYLK4 MYLK4 CAMK1G CAMK1G VDAC1 VDAC1 SLC8A3 SLC8A3 CALM3 CALM3 CALML4 CALML4 GRPR GRPR TPCN2 TPCN2 LOC102141439 LOC102141439 SLC25A5 SLC25A5 ATP2B2 ATP2B2 CAMK2D CAMK2D GRM1 GRM1 SPHK2 SPHK2 CHRNA7 CHRNA7 ATP2A3 ATP2A3 HTR7 HTR7 PLCZ1 PLCZ1 NOS1 NOS1 ENSMFAP00000009633 ENSMFAP00000009633 HTR2C HTR2C PRKACA PRKACA PPP3CC PPP3CC LOC102124047 LOC102124047 LOC102139130 LOC102139130 CACNA1B CACNA1B ADORA2B ADORA2B CALML3 CALML3 LOC102135686 LOC102135686 DRD5 DRD5 CHRM5 CHRM5 DRD1 DRD1 ATP2B4 ATP2B4 ENSMFAP00000011903 ENSMFAP00000011903 PLCE1 PLCE1 ADRB2 ADRB2 BDKRB2 BDKRB2 CYSLTR2 CYSLTR2 PRKCA PRKCA CHRM1 CHRM1 CHRM2 CHRM2 CYSLTR1 CYSLTR1 PLN PLN PTAFR PTAFR HRH1 HRH1 PRKACG PRKACG NTSR1 NTSR1 LTB4R2 LTB4R2 ATP2A2 ATP2A2 ADRA1A ADRA1A GRIN1 GRIN1 PRKCB PRKCB TRHR TRHR P2RX2 P2RX2 PLCD4 PLCD4 MCOLN2 MCOLN2 ASPH ASPH PPP3R1 PPP3R1 GRIN2D GRIN2D ATP2B3 ATP2B3 PDGFB PDGFB ADORA2A ADORA2A HRH2 HRH2 HTR6 HTR6 PDGFC PDGFC LHCGR LHCGR SPHK1 SPHK1 NOS2 NOS2 P2RX7 P2RX7 SLC25A4 SLC25A4 PPP3CB PPP3CB PDE1B PDE1B ENSMFAP00000020718 ENSMFAP00000020718 MCOLN3 MCOLN3 MCU MCU ITPR2 ITPR2 ITPKB ITPKB HTR2A HTR2A GNA14 GNA14 CAMK2A CAMK2A CACNA1G CACNA1G SLC25A6 SLC25A6 PLCB1 PLCB1 PHKB PHKB TACR1 TACR1 GNAS GNAS PRKACB PRKACB GNAL GNAL PHKA2 PHKA2 PLCD3 PLCD3 F2R F2R P2RX3 P2RX3 PDGFA PDGFA PLCB3 PLCB3 ADRA1B ADRA1B GRIN2C GRIN2C PHKG1 PHKG1 MYLK3 MYLK3 ATP2B1 ATP2B1 AGTR1 AGTR1 VDAC3 VDAC3 LOC102118733 LOC102118733 ERBB4 ERBB4 CASQ2 CASQ2 P2RX6 P2RX6 PLCG2 PLCG2 PRKCG PRKCG ITPR1 ITPR1 CACNA1F CACNA1F CAMK4 CAMK4 CXCR4 CXCR4 GRIN2A GRIN2A PLCB2 PLCB2 ENSMFAP00000033644 ENSMFAP00000033644 HTR2B HTR2B CCKAR CCKAR LOC102128954 LOC102128954 EGF EGF PPP3CA PPP3CA PTK2B PTK2B ADRA1D ADRA1D GNAQ GNAQ AVPR1A AVPR1A RYR3 RYR3 PHKG2 PHKG2 ENSMFAP00000035747 ENSMFAP00000035747 PDE1A PDE1A GRM5 GRM5 TNNC1 TNNC1 CACNA1H CACNA1H ADCY7 ADCY7 TNNC2 TNNC2 SLC25A31 SLC25A31 EGFR EGFR ADCY1 ADCY1 ADCY3 ADCY3 P2RX1 P2RX1 VDAC2 VDAC2 PHKA1 PHKA1 PDE1C PDE1C PDGFRA PDGFRA CACNA1I CACNA1I HTR5A HTR5A P2RX4 P2RX4 ERBB2 ERBB2 PPIF PPIF PTGFR PTGFR GNA11 GNA11 ORAI2 ORAI2 ITPR3 ITPR3 ITPKA ITPKA CALML6 CALML6 CAMK1D CAMK1D PTGER1 PTGER1 ERBB3 ERBB3 PLCD1 PLCD1 RYR1 RYR1 STIM2 STIM2 TPCN1 TPCN1 STIM1 STIM1 ADRB3 ADRB3 CACNA1A CACNA1A CACNA1D CACNA1D ADCY4 ADCY4 PLCG1 PLCG1 GNA15 GNA15 TACR3 TACR3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PDGFDPlatelet derived growth factor D. (370 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
PTGER3Prostaglandin E receptor 3. (410 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (289 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ENSMFAP00000001843Ig-like domain-containing protein. (181 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ORAI3ORAI calcium release-activated calcium modulator 3. (295 aa)
MYLKMyosin light chain kinase. (1914 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (398 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (398 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (753 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
CD38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system (By similarity). (301 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2412 aa)
RYR2Ryanodine receptor 2. (4943 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
MCOLN1Mucolipin-1; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion. Involved [...] (580 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
TBXA2RThromboxane A2 receptor. (455 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (443 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
VDAC1Uncharacterized protein. (289 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CALML4Calmodulin like 4. (193 aa)
GRPRGastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
TPCN2Two pore segment channel 2. (752 aa)
LOC102141439G_PROTEIN_RECEP_F1_2 domain-containing protein. (370 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
SPHK2Sphingosine kinase 2. (653 aa)
CHRNA7Uncharacterized protein. (510 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1051 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (480 aa)
PLCZ11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (638 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
LOC102124047Ig-like domain-containing protein. (217 aa)
LOC102139130Ig-like domain-containing protein. (118 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2277 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (394 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
LOC102135686Ig-like domain-containing protein. (191 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (478 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
ENSMFAP00000011903Ig-like domain-containing protein. (133 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
ADRB2Adrenergic receptor beta 2. (415 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (332 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
HRH1Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (487 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
LTB4R2Leukotriene B4 receptor 2. (389 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ADRA1AAdrenoceptor alpha 1A. (462 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
TRHRThyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (398 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (496 aa)
PLCD41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (799 aa)
MCOLN2Mucolipin 2. (566 aa)
ASPHAspartate beta-hydroxylase. (762 aa)
PPP3R1Uncharacterized protein. (189 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1062 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
HRH2Histamine receptor H2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (703 aa)
SPHK1Sphingosine kinase 1. (470 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1218 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
PDE1BPhosphodiesterase. (538 aa)
ENSMFAP00000020718Ig-like domain-containing protein. (193 aa)
MCOLN3Mucolipin 3. (553 aa)
MCUMitochondrial calcium uniporter. (351 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (941 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
GNA14G protein subunit alpha 14. (355 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
SLC25A6Solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
GNASGNAS complex locus. (1023 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNALG protein subunit alpha L. (450 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
PLCD3Phosphoinositide phospholipase C. (785 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (398 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (280 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
ADRA1BAdrenoceptor alpha 1B. (518 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1242 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (421 aa)
MYLK3Myosin light chain kinase 3. (819 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
LOC102118733Ig-like domain-containing protein. (192 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (407 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (408 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
ENSMFAP00000033644Ig-like domain-containing protein. (192 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
CCKARCholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
LOC102128954Ig-like domain-containing protein. (191 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
ADRA1DAdrenoceptor alpha 1D. (462 aa)
GNAQG protein subunit alpha q. (359 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
RYR3Ryanodine receptor 3. (4873 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
ENSMFAP00000035747Ig-like domain-containing protein. (198 aa)
PDE1APhosphodiesterase. (545 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2352 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
TNNC2Troponin C2, fast skeletal type. (160 aa)
SLC25A31ADP/ATP translocase 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility (By similarity). (315 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
VDAC2Uncharacterized protein. (308 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1227 aa)
PDE1CPhosphodiesterase. (768 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2111 aa)
HTR5A5-hydroxytryptamine receptor 5A. (357 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
ERBB2Receptor protein-tyrosine kinase. (1406 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GNA11G protein subunit alpha 11. (359 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (261 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
CALML6Calmodulin like 6. (181 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
PTGER1Prostaglandin E receptor 1. (402 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1353 aa)
PLCD1Phosphoinositide phospholipase C. (777 aa)
RYR1Ryanodine receptor 1. (4309 aa)
STIM2Stromal interaction molecule 2. (840 aa)
TPCN1Two pore segment channel 1. (888 aa)
STIM1Stromal interaction molecule 1. (770 aa)
ADRB3Adrenergic receptor beta 3. (418 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2370 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
GNA15G protein subunit alpha 15. (330 aa)
TACR3Tachykinin receptor 3; Belongs to the G-protein coupled receptor 1 family. (463 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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