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| | PDGFD | Platelet derived growth factor D. (370 aa) |
| | ARF1 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs p [...] (181 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | DGKE | Diacylglycerol kinase. (567 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | AVP | Arginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa) |
| | AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5. (364 aa) |
| | GRB2 | Growth factor receptor-binding protein 2. (217 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) |
| | LPAR6 | Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa) |
| | ENSMFAP00000001843 | Ig-like domain-containing protein. (181 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa) |
| | FCER1A | Fc fragment of IgE receptor Ia. (260 aa) |
| | RHOA | Uncharacterized protein. (141 aa) |
| | CYTH1 | Cytohesin 1. (401 aa) |
| | DNM3 | Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa) |
| | LPAR2 | Lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity). (351 aa) |
| | CYTH3 | Cytohesin 3. (399 aa) |
| | AVPR1B | Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa) |
| | ARF6 | ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa) |
| | RALA | RAS like proto-oncogene A. (206 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | ENSMFAP00000004742 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (347 aa) |
| | LOC102145495 | Ras-GEF domain-containing protein. (536 aa) |
| | GRM3 | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity). (879 aa) |
| | GRM6 | Glutamate metabotropic receptor 6. (753 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa) |
| | DGKI | Diacylglycerol kinase. (1079 aa) |
| | RHEB | Ras homolog, mTORC1 binding. (196 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | KIT | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa) |
| | GRM1 | Glutamate metabotropic receptor 1. (1195 aa) |
| | SPHK2 | Sphingosine kinase 2. (653 aa) |
| | CYTH4 | Cytohesin 4. (394 aa) |
| | DGKQ | Diacylglycerol kinase. (875 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa) |
| | GRM8 | Glutamate metabotropic receptor 8. (908 aa) |
| | PIK3R6 | Phosphoinositide-3-kinase regulatory subunit 6. (750 aa) |
| | ENSMFAP00000009633 | Uncharacterized protein. (245 aa) |
| | LOC102115767 | Ras-GEF domain-containing protein. (590 aa) |
| | LOC102124047 | Ig-like domain-containing protein. (217 aa) |
| | LOC102139130 | Ig-like domain-containing protein. (118 aa) |
| | TSC1 | TSC complex subunit 1. (1168 aa) |
| | AGT | SERPIN domain-containing protein; Belongs to the serpin family. (485 aa) |
| | LOC102135686 | Ig-like domain-containing protein. (191 aa) |
| | ENSMFAP00000011903 | Ig-like domain-containing protein. (133 aa) |
| | LPAR4 | Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa) |
| | PLPP3 | acidPPc domain-containing protein. (353 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | RRAS | RAS related. (218 aa) |
| | PLPP1 | Phospholipid phosphatase 1. (285 aa) |
| | DNM1 | Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | F2 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (620 aa) |
| | ENSMFAP00000017798 | Ras-GEF domain-containing protein. (400 aa) |
| | PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa) |
| | SPHK1 | Sphingosine kinase 1. (470 aa) |
| | LPAR1-2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | DGKZ | Diacylglycerol kinase. (1118 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | TSC2 | TSC complex subunit 2. (1807 aa) |
| | ENSMFAP00000020718 | Ig-like domain-containing protein. (193 aa) |
| | PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa) |
| | PLA2G4B | Phospholipase A2. (781 aa) |
| | CYTH2 | Uncharacterized protein. (400 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | GRM4 | Metabotropic glutamate receptor 4; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity). (912 aa) |
| | GNAS | GNAS complex locus. (1023 aa) |
| | RALGDS | Uncharacterized protein. (902 aa) |
| | AVPR2 | Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa) |
| | FCER1G | High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functi [...] (112 aa) |
| | PLA2G4A | Phospholipase A2. (749 aa) |
| | GAB1 | GRB2 associated binding protein 1. (751 aa) |
| | PLPP2 | Phospholipid phosphatase 2. (302 aa) |
| | RAPGEF4 | Rap guanine nucleotide exchange factor 4. (1011 aa) |
| | F2R | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (280 aa) |
| | PIP5K1C | Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (708 aa) |
| | KITLG | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa) |
| | SHC1 | SHC adaptor protein 1. (584 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | PLA2G4E | Phospholipase A2. (869 aa) |
| | PIK3R5 | Phosphoinositide-3-kinase regulatory subunit 5. (881 aa) |
| | AGTR1 | Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa) |
| | AGPAT4 | 1-acyl-sn-glycerol-3-phosphate acyltransferase delta; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity). (378 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | LOC102116894 | Ras-GEF domain-containing protein. (469 aa) |
| | LOC102118733 | Ig-like domain-containing protein. (192 aa) |
| | DGKB | Diacylglycerol kinase. (803 aa) |
| | DGKG | Diacylglycerol kinase. (791 aa) |
| | AGPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (283 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | NRAS | Uncharacterized protein. (189 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa) |
| | DGKD | Diacylglycerol kinase. (1209 aa) |
| | MS4A2 | Membrane spanning 4-domains A2. (245 aa) |
| | PLD1 | Phospholipase. (1074 aa) |
| | PLD2 | Phospholipase. (933 aa) |
| | ADCY5 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa) |
| | ENSMFAP00000033644 | Ig-like domain-containing protein. (192 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | GAB2 | GRB2 associated binding protein 2. (677 aa) |
| | ENSMFAP00000034139 | Ras-GEF domain-containing protein. (525 aa) |
| | LOC102128954 | Ig-like domain-containing protein. (191 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa) |
| | RRAS2 | RAS related 2. (204 aa) |
| | AVPR1A | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa) |
| | PLA2G4D | Phospholipase A2. (817 aa) |
| | AGPAT2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa) |
| | RAPGEF3 | Rap guanine nucleotide exchange factor 3. (923 aa) |
| | ENSMFAP00000035747 | Ig-like domain-containing protein. (198 aa) |
| | PIK3R2 | Uncharacterized protein. (694 aa) |
| | GRM5 | Glutamate metabotropic receptor 5. (1212 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | DGKH | Diacylglycerol kinase. (1220 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | LPAR3 | Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1382 aa) |
| | PLA2G4F | Phospholipase A2. (849 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa) |
| | RALB | Ras-related protein Ral-B; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By s [...] (212 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | DGKK | Diacylglycerol kinase. (1265 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa) |
| | GRM2 | Glutamate metabotropic receptor 2. (872 aa) |
| | DGKA | Diacylglycerol kinase. (735 aa) |
| | DNM2 | Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa) |
| | SHC2 | Uncharacterized protein. (516 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | GNA12 | G protein subunit alpha 12. (381 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | PTGFR | Prostaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | ENSMFAP00000041150 | Ras-GEF domain-containing protein. (525 aa) |
| | SHC3 | SHC adaptor protein 3. (598 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | MRAS | Uncharacterized protein. (208 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | ADCY4 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa) |
| | ENSMFAP00000044716 | Ras-GEF domain-containing protein. (527 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
