STRINGSTRING
MAP2K1 MAP2K1 PPP2R5E PPP2R5E CCNB2 CCNB2 SPDYA SPDYA ADCY6 ADCY6 STAG3 STAG3 PPP2R1A PPP2R1A ADCY8 ADCY8 CDC20 CDC20 ADCY2 ADCY2 FBXO43 FBXO43 YWHAZ YWHAZ PPP1CA PPP1CA AURKA AURKA MAPK1 MAPK1 PPP2R5C PPP2R5C CDC23 CDC23 MAPK11 MAPK11 RPS6KA6 RPS6KA6 CALM3 CALM3 CALML4 CALML4 ANAPC5 ANAPC5 CAMK2D CAMK2D ANAPC13 ANAPC13 ANAPC10 ANAPC10 PLCZ1 PLCZ1 INS INS SGO1 SGO1 PRKACA PRKACA YWHAQ YWHAQ CPEB2 CPEB2 PPP3CC PPP3CC BTRC BTRC SLK SLK CDC26 CDC26 CALML3 CALML3 MOS MOS LOC102142638 LOC102142638 PRKACG PRKACG ANAPC7 ANAPC7 IGF1 IGF1 ESPL1 ESPL1 PPP3R1 PPP3R1 PPP3CB PPP3CB ITPR2 ITPR2 CAMK2A CAMK2A PPP1CB PPP1CB YWHAB YWHAB SPDYC SPDYC MAD2L1 MAD2L1 REC8 REC8 PRKACB PRKACB CDC27 CDC27 CDK2 CDK2 YWHAH YWHAH RPS6KA1 RPS6KA1 RPS6KA3 RPS6KA3 SPDYE4 SPDYE4 PPP2R5B PPP2R5B MAPK3 MAPK3 ENSMFAP00000029671 ENSMFAP00000029671 FBXO5 FBXO5 CDC16 CDC16 PGR PGR AR AR ITPR1 ITPR1 IGF1R IGF1R BUB1 BUB1 CPEB4 CPEB4 ADCY5 ADCY5 SMC3 SMC3 PPP3CA PPP3CA PPP2CA PPP2CA SMC1A SMC1A SMC1B SMC1B PPP2R5A PPP2R5A ADCY7 ADCY7 MAPK14 MAPK14 PPP1CC PPP1CC ADCY1 ADCY1 ANAPC4 ANAPC4 ADCY3 ADCY3 YWHAG YWHAG PTTG1 PTTG1 MAD1L1 MAD1L1 PLK1 PLK1 CUL1 CUL1 MAD2L2 MAD2L2 PPP2R1B PPP2R1B ENSMFAP00000040719 ENSMFAP00000040719 CCNE1 CCNE1 ITPR3 ITPR3 CALML6 CALML6 FBXW11 FBXW11 RBX1 RBX1 PPP2R5D PPP2R5D ANAPC1 ANAPC1 SKP1 SKP1 PKMYT1 PKMYT1 CDK1 CDK1 ADCY4 ADCY4 PPP2CB PPP2CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
CCNB2G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (398 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (313 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
STAG3Stromal antigen 3. (1226 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A regulatory subunit A. (589 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CDC20WD_REPEATS_REGION domain-containing protein. (499 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
FBXO43F-box protein 43. (702 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (257 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
CDC23Cell division cycle 23. (597 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
RPS6KA6Ribosomal protein S6 kinase. (815 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CALML4Calmodulin like 4. (193 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
ANAPC13Anaphase promoting complex subunit 13. (74 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
PLCZ11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (638 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SGO1Shugoshin 1. (527 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (883 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
BTRCUncharacterized protein. (605 aa)
SLKSTE20 like kinase. (1236 aa)
CDC26Cell division cycle 26. (85 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (346 aa)
LOC102142638Protein kinase domain-containing protein. (297 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
ANAPC7Anaphase promoting complex subunit 7. (599 aa)
IGF1Insulin like growth factor 1. (159 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2120 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
YWHAB14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] (246 aa)
SPDYCSpeedy/RINGO cell cycle regulator family member C. (293 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2. (205 aa)
REC8REC8 meiotic recombination protein. (549 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CDC27Cell division cycle 27. (830 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
YWHAH14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
SPDYE4Speedy/RINGO cell cycle regulator family member E4. (237 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
ENSMFAP00000029671Uncharacterized protein. (345 aa)
FBXO5F-box protein 5. (448 aa)
CDC16Cell division cycle 16. (526 aa)
PGRProgesterone receptor. (936 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1091 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
SMC1BStructural maintenance of chromosomes protein. (1234 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
ANAPC4Anaphase promoting complex subunit 4. (981 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
PTTG1PTTG1 regulator of sister chromatid separation, securin. (202 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
ENSMFAP0000004071914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CALML6Calmodulin like 6. (181 aa)
FBXW11F-box and WD repeat domain containing 11. (542 aa)
RBX1RING-box protein 1. (108 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
ANAPC1Anaphase promoting complex subunit 1. (1944 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (167 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1. (568 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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