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| | PLAA | Uncharacterized protein. (795 aa) |
| | CALR | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (417 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1374 aa) |
| | UBQLN4 | Ubiquitin-like domain-containing protein. (601 aa) |
| | XBP1 | BZIP domain-containing protein. (380 aa) |
| | UFD1 | Ubiquitin recognition factor in ER associated degradation 1. (308 aa) |
| | SEL1L | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (870 aa) |
| | CRYAA | SHSP domain-containing protein; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (172 aa) |
| | LOC102122430 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (146 aa) |
| | CKAP4 | Cytoskeleton associated protein 4. (506 aa) |
| | CAPN1 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family. (732 aa) |
| | SEC31A | SEC31 homolog A, COPII coat complex component. (1250 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | DNAJC5 | DnaJ heat shock protein family (Hsp40) member C5. (198 aa) |
| | HYOU1 | Hypoxia up-regulated 1. (999 aa) |
| | DNAJC5B | DnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa) |
| | SSR3 | Translocon-associated protein subunit gamma. (185 aa) |
| | SEC61B | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa) |
| | UBE2G1 | Ubiquitin-conjugating enzyme E2 G1, N-terminally processed; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | MARCHF6 | Membrane associated ring-CH-type finger 6. (910 aa) |
| | TRAM1 | Translocating chain-associated membrane protein; Belongs to the TRAM family. (374 aa) |
| | SYVN1 | Synoviolin 1. (617 aa) |
| | EDEM1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (657 aa) |
| | LMAN1L | Lectin, mannose binding 1 like. (508 aa) |
| | ATF6B | Activating transcription factor 6 beta. (708 aa) |
| | DERL3 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (238 aa) |
| | SEC24C | Uncharacterized protein. (1094 aa) |
| | ERO1A | Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa) |
| | SEC23A | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa) |
| | BCL2 | BCL2 apoptosis regulator. (242 aa) |
| | ERP29 | Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa) |
| | RRBP1 | Ribosome binding protein 1. (1440 aa) |
| | SEC62 | SEC62 homolog, preprotein translocation factor. (399 aa) |
| | HSPH1 | Heat shock protein family H (Hsp110) member 1. (978 aa) |
| | UBQLN3 | Uncharacterized protein. (655 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | DAD1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (113 aa) |
| | TRAM1L1 | Translocating chain-associated membrane protein; Belongs to the TRAM family. (369 aa) |
| | VCP | Valosin containing protein; Belongs to the AAA ATPase family. (806 aa) |
| | FBXO2 | F-box protein 2. (297 aa) |
| | ENSMFAP00000014199 | HATPase_c domain-containing protein. (307 aa) |
| | ENSMFAP00000014202 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (571 aa) |
| | YOD1 | YOD1 deubiquitinase. (348 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa) |
| | RPN2 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (648 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | ENSMFAP00000017492 | Uncharacterized protein. (585 aa) |
| | CANX | Calnexin. (592 aa) |
| | RAD23B | Uncharacterized protein. (409 aa) |
| | DNAJA1 | Uncharacterized protein. (397 aa) |
| | MBTPS1 | Membrane bound transcription factor peptidase, site 1. (1054 aa) |
| | EDEM3 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (948 aa) |
| | ERLEC1 | Endoplasmic reticulum lectin 1. (483 aa) |
| | DNAJC10 | DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (793 aa) |
| | RNF5 | Ring finger protein 5. (180 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | SIL1 | SIL1 nucleotide exchange factor. (468 aa) |
| | HSPA2 | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (641 aa) |
| | DNAJB12 | DnaJ heat shock protein family (Hsp40) member B12. (409 aa) |
| | FBXO6 | F-box protein 6. (293 aa) |
| | SEC31B | SEC31 homolog B, COPII coat complex component. (1176 aa) |
| | SEC61A1 | SEC61 translocon alpha 1 subunit. (482 aa) |
| | UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2. (1518 aa) |
| | BAG2 | BAG domain-containing protein. (211 aa) |
| | NSFL1C | NSFL1 cofactor. (372 aa) |
| | LMAN2 | Lectin, mannose binding 2. (321 aa) |
| | ATXN3 | Josephin domain-containing protein. (375 aa) |
| | LMAN1 | Lectin, mannose binding 1. (510 aa) |
| | HSPBP1 | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity). (364 aa) |
| | DERL1 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa) |
| | ERO1B | Endoplasmic reticulum oxidoreductase 1 beta. (467 aa) |
| | UBXN1 | UBX domain protein 1. (310 aa) |
| | GANAB | Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia. (969 aa) |
| | STT3B | STT3 oligosaccharyltransferase complex catalytic subunit B. (825 aa) |
| | SEC23B | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa) |
| | SSR4 | Signal sequence receptor subunit 4. (173 aa) |
| | AMFR | Autocrine motility factor receptor. (643 aa) |
| | MAN1A2 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (645 aa) |
| | MBTPS2 | Membrane bound transcription factor peptidase, site 2. (520 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | DERL2 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa) |
| | MOGS | Mannosyl-oligosaccharide glucosidase. (837 aa) |
| | DNAJB1 | DnaJ heat shock protein family (Hsp40) member B1. (340 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (398 aa) |
| | MAN1B1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (699 aa) |
| | UBE4B | Ubiquitination factor E4B. (1302 aa) |
| | RNF185 | Ring finger protein 185. (192 aa) |
| | SEC24A | SEC24 homolog A, COPII coat complex component. (1093 aa) |
| | TXNDC5 | Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (431 aa) |
| | HSP90B1 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (804 aa) |
| | SEC13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa) |
| | UBXN4 | UBX domain protein 4. (508 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (831 aa) |
| | SAR1B | Secretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa) |
| | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (149 aa) |
| | CAPN2 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs; Belongs to the peptidase C2 family. (703 aa) |
| | HSPA4L | Heat shock protein family A (Hsp70) member 4 like. (840 aa) |
| | DNAJA2 | DnaJ heat shock protein family (Hsp40) member A2. (412 aa) |
| | RPN1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (607 aa) |
| | DNAJC1 | DnaJ heat shock protein family (Hsp40) member C1. (556 aa) |
| | SEC61A2 | SEC61 translocon alpha 2 subunit. (476 aa) |
| | EDEM2 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa) |
| | CRYAB | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa) |
| | HERPUD1 | Homocysteine inducible ER protein with ubiquitin like domain 1. (391 aa) |
| | UGGT1 | UDP-glucose glycoprotein glucosyltransferase 1. (1556 aa) |
| | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3. (504 aa) |
| | STT3A | STT3 oligosaccharyltransferase complex catalytic subunit A. (705 aa) |
| | SEL1L2 | SEL1L2 adaptor subunit of ERAD E3 ligase. (687 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | PDIA4 | Protein disulfide-isomerase A4. (644 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | UBXN2A | UBX domain protein 2A. (260 aa) |
| | HSP90AB1 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa) |
| | HSPA8 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa) |
| | P4HB | Protein disulfide-isomerase. (510 aa) |
| | UBXN8 | UBX domain protein 8. (270 aa) |
| | SEC24B | SEC24 homolog B, COPII coat complex component. (1277 aa) |
| | SEC24D | SEC24 homolog D, COPII coat complex component. (1033 aa) |
| | MAN1C1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (630 aa) |
| | PRKCSH | Protein kinase C substrate 80K-H. (534 aa) |
| | ATF6 | Activating transcription factor 6. (669 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | DDOST | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (456 aa) |
| | NGLY1 | Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins [...] (654 aa) |
| | UBE2J1 | Ubiquitin conjugating enzyme E2 J1. (318 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (606 aa) |
| | DNAJB2 | J domain-containing protein. (324 aa) |
| | SVIP | Small VCP interacting protein. (77 aa) |
| | MAN1A1 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (653 aa) |
| | HSPA5 | Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa) |
| | BCAP31 | B cell receptor associated protein 31. (313 aa) |
| | SAR1A | Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family. (198 aa) |
| | SSR2 | Signal sequence receptor subunit 2. (263 aa) |
| | RBX1 | RING-box protein 1. (108 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (978 aa) |
| | UBE2G2 | Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (165 aa) |
| | PREB | WD_REPEATS_REGION domain-containing protein. (419 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (890 aa) |
| | DNAJB11 | J domain-containing protein. (358 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (167 aa) |
| | SEC61G | SEC61 translocon gamma subunit. (68 aa) |
| | SSR1 | Signal sequence receptor subunit 1. (298 aa) |
| | TUSC3 | Tumor suppressor candidate 3. (348 aa) |
| | SEC63 | SEC63 homolog, protein translocation regulator. (760 aa) |
| | PDIA6 | Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (492 aa) |
| | EIF2AK1 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] (631 aa) |
| | UBXN6 | UBX domain-containing protein 6. (441 aa) |
| | UBE2D4 | Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | ATF4 | Activating transcription factor 4. (351 aa) |
| | HSPA1L | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (643 aa) |
