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| | CTSF | Cathepsin F; Belongs to the peptidase C1 family. (484 aa) |
| | CD63 | Tetraspanin. (238 aa) |
| | CTSA | Carboxypeptidase; Belongs to the peptidase S10 family. (494 aa) |
| | CTSG | Cathepsin G; Belongs to the peptidase S1 family. (255 aa) |
| | AP4E1 | AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1098 aa) |
| | CTSH | Cathepsin H; Belongs to the peptidase C1 family. (335 aa) |
| | AP1S2 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa) |
| | CLTB | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa) |
| | MCOLN1 | Mucolipin-1; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion. Involved [...] (580 aa) |
| | NAGA | Alpha-galactosidase. (411 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (557 aa) |
| | ABCB9 | ATP binding cassette subfamily B member 9. (766 aa) |
| | GALC | Galactosylceramidase. (685 aa) |
| | AP3B2 | AP-3 complex subunit beta. (1101 aa) |
| | CTNS | Cystinosin, lysosomal cystine transporter. (400 aa) |
| | LITAFD | LITAF domain containing. (72 aa) |
| | SPAM1 | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. (512 aa) |
| | CD164 | CD164 molecule. (197 aa) |
| | CTSO | Cathepsin O; Belongs to the peptidase C1 family. (321 aa) |
| | ABCA2 | ATP binding cassette subfamily A member 2. (2469 aa) |
| | AP4M1 | AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa) |
| | MANBA | Mannosidase beta. (879 aa) |
| | CTSZ | Cathepsin Z; Belongs to the peptidase C1 family. (368 aa) |
| | GGA3 | Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (723 aa) |
| | FUCA1 | Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family. (571 aa) |
| | LOC102143665 | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. (320 aa) |
| | LOC102129964 | DUF1624 domain-containing protein. (518 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (787 aa) |
| | CTSB | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. (339 aa) |
| | ARSG | Arylsulfatase G. (525 aa) |
| | GBA | Glucosylceramidase. (533 aa) |
| | AP4B1 | AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa) |
| | NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (515 aa) |
| | LAPTM5 | Uncharacterized protein. (283 aa) |
| | SGSH | N-sulfoglucosamine sulfohydrolase. (502 aa) |
| | CTSE | Cathepsin E; Belongs to the peptidase A1 family. (396 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (411 aa) |
| | AP1S1 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa) |
| | PSAP | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (539 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (423 aa) |
| | ENSMFAP00000016806 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (107 aa) |
| | CTSC | Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity). (463 aa) |
| | IDUA | Iduronidase alpha-L-. (653 aa) |
| | GGA2 | Golgi associated, gamma adaptin ear containing, ARF binding protein 2. (616 aa) |
| | GLA | Alpha-galactosidase. (429 aa) |
| | CLTCL1 | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1640 aa) |
| | GM2A | Ganglioside GM2 activator; Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). (190 aa) |
| | CD68 | CD68 molecule. (354 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa) |
| | AP3D1 | AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1215 aa) |
| | TPP1 | Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). (563 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | CTSV | Cathepsin V; Belongs to the peptidase C1 family. (334 aa) |
| | NPC2 | NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] (202 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (629 aa) |
| | LIPA | Lysosomal acid lipase/cholesteryl ester hydrolase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation (By similarity). (399 aa) |
| | AP1M1 | AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (435 aa) |
| | MAN2B1 | Lysosomal alpha-mannosidase; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover; Belongs to the glycosyl hydrolase 38 family. (1012 aa) |
| | GAA | Glucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (952 aa) |
| | HYAL3 | Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa) |
| | SORT1 | Sortilin. (831 aa) |
| | ATP6V0C | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (128 aa) |
| | SLC11A1 | Solute carrier family 11 member 1. (547 aa) |
| | GGA1 | Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (639 aa) |
| | LGMN | Legumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). (433 aa) |
| | LITAF | Lipopolysaccharide induced TNF factor. (161 aa) |
| | CLN5 | Uncharacterized protein. (358 aa) |
| | FUCA2 | Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (465 aa) |
| | SLC17A5 | Solute carrier family 17 member 5. (495 aa) |
| | ENSMFAP00000027078 | Uncharacterized protein. (654 aa) |
| | ACP5 | Tartrate-resistant acid phosphatase type 5. (325 aa) |
| | CLTA | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa) |
| | AP3M1 | AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes; Belongs to the adaptor complexes medium subunit family. (418 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (259 aa) |
| | AP3M2 | AP-3 complex subunit mu-2. (418 aa) |
| | CTSL | Cathepsin L; Belongs to the peptidase C1 family. (333 aa) |
| | GALNS | Galactosamine (N-acetyl)-6-sulfatase. (522 aa) |
| | HYAL4 | Hyaluronidase. (481 aa) |
| | LOC102122749 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (415 aa) |
| | LAPTM4A | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. (233 aa) |
| | IDS | Sulfatase domain-containing protein. (549 aa) |
| | HYAL1 | Hyaluronidase. (435 aa) |
| | M6PR | Mannose-6-phosphate receptor, cation dependent. (278 aa) |
| | AP3S1 | Adaptor related protein complex 3 subunit sigma 1. (193 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (470 aa) |
| | DNASE2 | Uncharacterized protein. (360 aa) |
| | AGA | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. Belongs to the Ntn-hydrolase family. (346 aa) |
| | SLC11A2 | Natural resistance-associated macrophage protein 2. (568 aa) |
| | HEXB | Beta-hexosaminidase. (557 aa) |
| | ARSB | Arylsulfatase B. (534 aa) |
| | IGF2R | Insulin like growth factor 2 receptor. (2491 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa) |
| | AP1G1 | AP-1 complex subunit gamma. (817 aa) |
| | GNPTAB | N-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1256 aa) |
| | AP1G2 | AP-1 complex subunit gamma. (785 aa) |
| | SUMF1 | Sulfatase modifying factor 1. (374 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (331 aa) |
| | NEU1 | Neuraminidase 1. (416 aa) |
| | ARSA | Arylsulfatase A. (599 aa) |
| | GUSB | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (651 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (552 aa) |
| | DNASE2B | Uncharacterized protein. (361 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1063 aa) |
| | PLA2G15 | Phospholipase A2 group XV. (412 aa) |
| | CLN3 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. (438 aa) |
| | AP1B1 | AP complex subunit beta. (949 aa) |
| | NAGLU | N-acetyl-alpha-glucosaminidase. (743 aa) |
| | SCARB2 | Scavenger receptor class B member 2; Belongs to the CD36 family. (478 aa) |
| | CLTC | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa) |
| | AP1S3 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (164 aa) |
| | NPC1 | NPC intracellular cholesterol transporter 1. (1277 aa) |
| | ASAH1 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (411 aa) |
| | CTSK | Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (329 aa) |
| | ACP2 | Lysosomal acid phosphatase. (423 aa) |
| | HYAL2 | Hyaluronidase. (473 aa) |
