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ATP6V1D ATP6V1D CALR CALR DYNC2H1 DYNC2H1 ATP6V1A ATP6V1A MRC1 MRC1 HLA-E HLA-E EEA1 EEA1 HLA-DPA1 HLA-DPA1 HLA-F HLA-F ENSMFAP00000001843 ENSMFAP00000001843 TUBB3 TUBB3 ATP6V1G1 ATP6V1G1 DYNC1I1 DYNC1I1 LOC102140782 LOC102140782 TUBA8 TUBA8 VAMP3 VAMP3 ENSMFAP00000004499 ENSMFAP00000004499 SEC61B SEC61B RAB5A RAB5A LOC102125623 LOC102125623 ATP6V1B2 ATP6V1B2 RAB7A RAB7A CYBB CYBB ITGB2 ITGB2 THBS2 THBS2 NCF2 NCF2 HLA-DRB5 HLA-DRB5 ENSMFAP00000008465 ENSMFAP00000008465 FCGR1A FCGR1A RILP RILP NOS1 NOS1 COLEC11 COLEC11 DQB1 DQB1 LOC102124047 LOC102124047 LOC102139130 LOC102139130 ITGB5 ITGB5 HGS HGS LOC102135686 LOC102135686 TUBA4A TUBA4A TLR2 TLR2 ATP6V0A1 ATP6V0A1 ATP6V1E2 ATP6V1E2 ENSMFAP00000011903 ENSMFAP00000011903 TUBB4B TUBB4B CD14 CD14 LAMP2 LAMP2 RAB5B RAB5B MPO MPO TCIRG1 TCIRG1 CORO1A CORO1A ITGAM ITGAM LAMP1 LAMP1 MSR1 MSR1 DYNC1LI1 DYNC1LI1 ITGA2 ITGA2 CLEC7A CLEC7A RAB7B RAB7B CANX CANX Mafa-B Mafa-B ACTB ACTB MBL2 MBL2 HLA-DRA HLA-DRA CYBA CYBA LOC102114865 LOC102114865 ATP6V1G2 ATP6V1G2 ATP6V1C2 ATP6V1C2 ATP6V1E1 ATP6V1E1 THBS1 THBS1 ATP6V1H ATP6V1H ENSMFAP00000020718 ENSMFAP00000020718 THBS4 THBS4 ATP6V0D2 ATP6V0D2 TUBA1C TUBA1C LOC102135038 LOC102135038 ENSMFAP00000022650 ENSMFAP00000022650 SEC22B SEC22B LOC102140945 LOC102140945 ATP6V1F ATP6V1F STX18 STX18 LOC102123543 LOC102123543 SEC61A1 SEC61A1 ATP6V0C ATP6V0C CD36 CD36 TUBB2B TUBB2B C3 C3 FCAR FCAR OLR1 OLR1 LOC102123548 LOC102123548 ATP6V1C1 ATP6V1C1 LOC102141835 LOC102141835 ATP6V0E1 ATP6V0E1 ATP6V0B ATP6V0B SFTPD SFTPD CTSL CTSL PIKFYVE PIKFYVE DYNC1LI2 DYNC1LI2 PLA2R1 PLA2R1 LOC102118733 LOC102118733 TUBAL3 TUBAL3 ATP6V1B1 ATP6V1B1 TUBA1A TUBA1A ITGA5 ITGA5 TAP2 TAP2 M6PR M6PR ENSMFAP00000033644 ENSMFAP00000033644 NCF4 NCF4 ATP6AP1 ATP6AP1 HLA-DOB HLA-DOB STX12 STX12 STX7 STX7 LOC102128954 LOC102128954 TUBB TUBB ITGAV ITGAV LOC102140649 LOC102140649 COMP COMP SEC61A2 SEC61A2 PIK3C3 PIK3C3 ENSMFAP00000035747 ENSMFAP00000035747 ITGB1 ITGB1 LOC102121218 LOC102121218 NCF1 NCF1 FCGR2B FCGR2B TUBB1 TUBB1 THBS3 THBS3 CTSS CTSS C1R C1R LOC102132794 LOC102132794 DYNC1I2 DYNC1I2 LOC102125518 LOC102125518 TAP1 TAP1 ATP6V0A2 ATP6V0A2 ITGB3 ITGB3 TUBB6 TUBB6 HLA-DOA HLA-DOA MARCO MARCO TLR4 TLR4 LOC102119798 LOC102119798 SEC61G SEC61G MRC2 MRC2 RAB5C RAB5C SCARB1 SCARB1 COLEC12 COLEC12 TFRC TFRC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ATP6V1DATPase H+ transporting V1 subunit D. (250 aa)
CALRCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (417 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4314 aa)
ATP6V1AUncharacterized protein. (617 aa)
MRC1Mannose receptor C-type 1. (1456 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (382 aa)
EEA1Early endosome antigen 1. (1453 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (443 aa)
ENSMFAP00000001843Ig-like domain-containing protein. (181 aa)
TUBB3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (507 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
DYNC1I1WD_REPEATS_REGION domain-containing protein. (645 aa)
LOC102140782Ig-like domain-containing protein. (325 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
VAMP3Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. (100 aa)
ENSMFAP00000004499Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (414 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
LOC102125623Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
ATP6V1B2ATPase H+ transporting V1 subunit B2. (632 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
ITGB2Integrin beta. (874 aa)
THBS2Thrombospondin 2. (1172 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
HLA-DRB5Ig-like domain-containing protein. (286 aa)
ENSMFAP00000008465C-type lectin domain-containing protein. (249 aa)
FCGR1AUncharacterized protein. (375 aa)
RILPRab interacting lysosomal protein. (395 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
COLEC11C-type lectin domain-containing protein. (280 aa)
DQB1Ig-like domain-containing protein. (156 aa)
LOC102124047Ig-like domain-containing protein. (217 aa)
LOC102139130Ig-like domain-containing protein. (118 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (830 aa)
LOC102135686Ig-like domain-containing protein. (191 aa)
TUBA4ATubulin alpha-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (448 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (787 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
ENSMFAP00000011903Ig-like domain-containing protein. (133 aa)
TUBB4BTubulin beta-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
CD14Uncharacterized protein. (384 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
RAB5BUncharacterized protein. (221 aa)
MPOMyeloperoxidase. (745 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
CORO1ACoronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. (461 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1147 aa)
LAMP1Lysosomal associated membrane protein 1. (423 aa)
MSR1Macrophage scavenger receptor 1. (451 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (466 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
CLEC7AC-type lectin domain containing 7A. (281 aa)
RAB7BRAB7B, member RAS oncogene family. (189 aa)
CANXCalnexin. (592 aa)
Mafa-BMHC_I-like_Ag-recog domain-containing protein. (139 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (379 aa)
MBL2Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (255 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
LOC102114865Ig-like domain-containing protein; Belongs to the MHC class I family. (244 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
ATP6V1E1V-type proton ATPase subunit E 1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (226 aa)
THBS1Thrombospondin 1. (1173 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
ENSMFAP00000020718Ig-like domain-containing protein. (193 aa)
THBS4Thrombospondin 4. (961 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (484 aa)
LOC102135038Uncharacterized protein; Belongs to the peptidase S1 family. (664 aa)
ENSMFAP00000022650C-type lectin domain-containing protein. (265 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
LOC102140945Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Binds IgG1 and IgG2 (By similarity). (277 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (147 aa)
STX18Syntaxin 18. (349 aa)
LOC102123543Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (482 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (128 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
TUBB2BTubulin beta-2A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. (445 aa)
C3Complement C3. (1663 aa)
FCARFc fragment of IgA receptor. (287 aa)
OLR1Oxidized low density lipoprotein receptor 1. (291 aa)
LOC102123548Ig-like domain-containing protein; Belongs to the MHC class I family. (363 aa)
ATP6V1C1V-type proton ATPase subunit C 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). (382 aa)
LOC102141835Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (259 aa)
SFTPDSurfactant protein D. (375 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
DYNC1LI2Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity). (492 aa)
PLA2R1Phospholipase A2 receptor 1. (1466 aa)
LOC102118733Ig-like domain-containing protein. (192 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
TUBA1ADetyrosinated tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
TAP2Transporter 2, ATP binding cassette subfamily B member. (703 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (278 aa)
ENSMFAP00000033644Ig-like domain-containing protein. (192 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (470 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
LOC102128954Ig-like domain-containing protein. (191 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
LOC102140649Ig-like domain-containing protein. (263 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
SEC61A2SEC61 translocon alpha 2 subunit. (476 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
ENSMFAP00000035747Ig-like domain-containing protein. (198 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
LOC102121218Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
FCGR2BUncharacterized protein. (317 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
THBS3Thrombospondin 3. (956 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
C1RComplement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. (698 aa)
LOC102132794Ig-like domain-containing protein; Belongs to the MHC class I family. (334 aa)
DYNC1I2Dynein cytoplasmic 1 intermediate chain 2. (638 aa)
LOC102125518Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (450 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (808 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (552 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
MARCOMacrophage receptor with collagenous structure. (520 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa)
LOC102119798C-type lectin domain-containing protein. (248 aa)
SEC61GSEC61 translocon gamma subunit. (68 aa)
MRC2Mannose receptor C type 2. (1479 aa)
RAB5CRAB5C, member RAS oncogene family. (249 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
COLEC12Collectin subfamily member 12. (742 aa)
TFRCTransferrin receptor. (760 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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