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| | GLUL | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] (373 aa) |
| | PYGB | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | STAT3 | Signal transducer and activator of transcription. (802 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | CAPN1 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family. (732 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (336 aa) |
| | VPS4A | Uncharacterized protein; Belongs to the AAA ATPase family. (498 aa) |
| | LOC102141352 | Uncharacterized protein. (198 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (445 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | H2AZ1 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | PPIA | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | PPID | Uncharacterized protein. (370 aa) |
| | VDAC1 | Uncharacterized protein. (289 aa) |
| | ENSMFAP00000006305 | Uncharacterized protein. (62 aa) |
| | CHMP2A | Charged multivesicular body protein 2A. (222 aa) |
| | CYBB | Cytochrome b-245 beta chain. (570 aa) |
| | SLC25A5 | Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | CHMP2B | Charged multivesicular body protein 2B. (218 aa) |
| | CAMK2D | Protein kinase domain-containing protein. (533 aa) |
| | LOC102141744 | Uncharacterized protein. (198 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (404 aa) |
| | H2AC21 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H2AC1 | Histone H2A; Belongs to the histone H2A family. (131 aa) |
| | H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | DNM1L | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa) |
| | ENSMFAP00000010221 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | PYGL | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa) |
| | BCL2 | BCL2 apoptosis regulator. (242 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | H2AC6 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H2AC12 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | G8F3V0_MACFA | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | LOC102140303 | Uncharacterized protein. (190 aa) |
| | H2AC7 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | H2AJ | Histone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (129 aa) |
| | TICAM2 | TIR domain-containing adaptor molecule 2. (235 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (311 aa) |
| | H2AW | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | H2AC14 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (233 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (187 aa) |
| | LOC102146717 | Uncharacterized protein. (189 aa) |
| | ENSMFAP00000014199 | HATPase_c domain-containing protein. (307 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (554 aa) |
| | ZBP1 | Z-DNA binding protein 1. (420 aa) |
| | CHMP7 | Charged multivesicular body protein 7. (453 aa) |
| | FAF1 | Fas associated factor 1. (650 aa) |
| | TRPM7 | Transient receptor potential cation channel subfamily M member 7. (1848 aa) |
| | SLC25A4 | Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | SQSTM1 | Sequestosome 1. (440 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | PLA2G4B | Phospholipase A2. (781 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (629 aa) |
| | MACROH2A2 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (271 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | FTH1-2 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (162 aa) |
| | SLC25A6 | Solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (477 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) |
| | PLA2G4A | Phospholipase A2. (749 aa) |
| | CHMP3 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (231 aa) |
| | LOC101926166 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (562 aa) |
| | TYK2 | Tyrosine-protein kinase. (1190 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase. (662 aa) |
| | BID | BH3 interacting domain death agonist. (244 aa) |
| | CHMP5 | Charged multivesicular body protein 5. (219 aa) |
| | PLA2G4E | Phospholipase A2. (869 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | VDAC3 | Voltage dependent anion channel 3. (284 aa) |
| | MLKL | Mixed lineage kinase domain like pseudokinase. (470 aa) |
| | RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa) |
| | TNFRSF1A | Uncharacterized protein. (455 aa) |
| | VPS4B | Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (532 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (398 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | IL33 | Interleukin 33. (270 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | STAT2 | Signal transducer and activator of transcription. (851 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (831 aa) |
| | LOC102137290 | Uncharacterized protein. (643 aa) |
| | GLUD2 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (534 aa) |
| | PGAM5 | Uncharacterized protein. (140 aa) |
| | CAPN2 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs; Belongs to the peptidase C2 family. (703 aa) |
| | JAK1 | Tyrosine-protein kinase. (1159 aa) |
| | CHMP6 | Charged multivesicular body protein 6. (209 aa) |
| | JAK2 | Tyrosine-protein kinase. (1139 aa) |
| | IFNGR1 | Uncharacterized protein. (488 aa) |
| | PLA2G4D | Phospholipase A2. (817 aa) |
| | JAK3 | Tyrosine-protein kinase. (1124 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa) |
| | SLC25A31 | ADP/ATP translocase 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility (By similarity). (315 aa) |
| | CHMP1A | Charged multivesicular body protein 1A. (196 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1035 aa) |
| | PLA2G4F | Phospholipase A2. (849 aa) |
| | HSP90AB1 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (381 aa) |
| | VDAC2 | Uncharacterized protein. (308 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | SPATA2 | Spermatogenesis associated 2. (520 aa) |
| | STAT4 | Signal transducer and activator of transcription. (748 aa) |
| | ENSMFAP00000042558 | Uncharacterized protein. (170 aa) |
| | CHMP4B | Charged multivesicular body protein 4B. (224 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (497 aa) |
| | RNF31 | Uncharacterized protein. (1072 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa) |
| | SPATA2L | Spermatogenesis associated 2 like. (424 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | IFNAR2 | Uncharacterized protein. (735 aa) |
| | PYGM | Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). (842 aa) |
| | AIFM1 | Apoptosis inducing factor mitochondria associated 1. (613 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in [...] (790 aa) |
