STRINGSTRING
TGFB1 TGFB1 HJV HJV ID2 ID2 E2F4 E2F4 LEFTY1 LEFTY1 BAMBI BAMBI RHOA RHOA TNF TNF PPP2R1A PPP2R1A SMAD3 SMAD3 CHRD CHRD MAPK1 MAPK1 RGMB RGMB TGFB2 TGFB2 BMPR1A BMPR1A GDF7 GDF7 SMURF2 SMURF2 BMP6 BMP6 BMP4 BMP4 TGIF2 TGIF2 NEO1 NEO1 TGFB3 TGFB3 NOG NOG RBL1 RBL1 GREM2 GREM2 FST FST BMP5 BMP5 RPS6KB2 RPS6KB2 RGMA RGMA ACVR1B ACVR1B BMPR2 BMPR2 BMP7 BMP7 INHBC INHBC THBS1 THBS1 SMURF1 SMURF1 TFDP1 TFDP1 INHBE INHBE THSD4 THSD4 SMAD7 SMAD7 INHBB INHBB RPS6KB1 RPS6KB1 IFNG IFNG BMP2 BMP2 LTBP1 LTBP1 SMAD6 SMAD6 TGFBR1 TGFBR1 SP1 SP1 ID3 ID3 SMAD2 SMAD2 MAPK3 MAPK3 ACVR1C ACVR1C ACVR1 ACVR1 GDF5 GDF5 BMPR1B BMPR1B SMAD4 SMAD4 TGIF1 TGIF1 ACVR2A ACVR2A ID1 ID1 ROCK1 ROCK1 AMH AMH TGFBR2 TGFBR2 PPP2CA PPP2CA HAMP HAMP CREBBP CREBBP DCN DCN NBL1 NBL1 SMAD1 SMAD1 INHBA INHBA FMOD FMOD CUL1 CUL1 PPP2R1B PPP2R1B ACVR2B ACVR2B NODAL NODAL RBX1 RBX1 ZFYVE9 ZFYVE9 MYC MYC ZFYVE16 ZFYVE16 FBN1 FBN1 SKP1 SKP1 SMAD5 SMAD5 LOC102144954 LOC102144954 PITX2 PITX2 GDF6 GDF6 PPP2CB PPP2CB EP300 EP300
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
E2F4E2F transcription factor 4. (416 aa)
LEFTY1Left-right determination factor. (366 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
RHOAUncharacterized protein. (141 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A regulatory subunit A. (589 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (479 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GDF7Growth differentiation factor 7. (450 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
NEO1Neogenin 1. (1434 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
RBL1RB transcriptional corepressor like 1. (1067 aa)
GREM2Gremlin. (168 aa)
FSTFollistatin. (344 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
RGMARepulsive guidance molecule A; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inacti [...] (458 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
INHBCInhibin subunit beta C. (352 aa)
THBS1Thrombospondin 1. (1173 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
TFDP1Transcription factor. (410 aa)
INHBEInhibin subunit beta E. (351 aa)
THSD4Thrombospondin type 1 domain containing 4. (1017 aa)
SMAD7Mothers against decapentaplegic homolog. (495 aa)
INHBBInhibin subunit beta B. (360 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
BMP2Bone morphogenetic protein 2. (544 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1683 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SP1Sp1 transcription factor. (786 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (488 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
GDF5Growth differentiation factor 5. (499 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGIF1TGFB induced factor homeobox 1. (312 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
AMHAnti-Mullerian hormone. (562 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
CREBBPCREB binding protein. (2442 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
NBL1NBL1, DAN family BMP antagonist. (216 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
INHBAInhibin subunit beta A. (426 aa)
FMODFibromodulin. (444 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
NODALNodal growth differentiation factor. (347 aa)
RBX1RING-box protein 1. (108 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
ZFYVE16Zinc finger FYVE-type containing 16. (1540 aa)
FBN1Fibrillin 1. (2871 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (167 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
LOC102144954Left-right determination factor. (366 aa)
PITX2Homeobox protein. (325 aa)
GDF6Growth differentiation factor 6. (455 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
EP300E1A binding protein p300. (2414 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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