STRINGSTRING
MAP2K1 MAP2K1 CCND1 CCND1 MYL3 MYL3 HRAS HRAS CCN2 CCN2 PRKAA1 PRKAA1 PLCB4 PLCB4 ADCY6 ADCY6 MYLK MYLK GNGT1 GNGT1 SLC8A2 SLC8A2 ADCY8 ADCY8 RYR2 RYR2 ADCY2 ADCY2 GNA13 GNA13 SMAD3 SMAD3 NOS3 NOS3 MAPK1 MAPK1 PRKAB1 PRKAB1 MYLK4 MYLK4 ENSMFAP00000006047 ENSMFAP00000006047 GNG4 GNG4 SLC8A3 SLC8A3 CALM3 CALM3 CALML4 CALML4 TFAM TFAM SPHK2 SPHK2 GNAI1 GNAI1 GNGT2 GNGT2 NOS1 NOS1 PIK3R6 PIK3R6 PRKACA PRKACA CALML3 CALML3 EGR1 EGR1 RRAS RRAS GNB3 GNB3 APLNR APLNR GNG5 GNG5 PRKACG PRKACG PIK3R4 PIK3R4 LIPE LIPE MEF2D MEF2D RPS6KB2 RPS6KB2 PRKAA2 PRKAA2 AKT1 AKT1 CDH1 CDH1 SPHK1 SPHK1 NOS2 NOS2 ADCY10 ADCY10 GNAI2 GNAI2 JAG1 JAG1 PIK3CG PIK3CG HDAC4 HDAC4 AKT3 AKT3 GNG11 GNG11 ITPR2 ITPR2 NRF1 NRF1 GNG12 GNG12 PLCB1 PLCB1 HDAC5 HDAC5 RPS6KB1 RPS6KB1 PDE3B PDE3B UCP1 UCP1 PRKACB PRKACB PRKAG3 PRKAG3 RPS6 RPS6 MEF2C MEF2C PLCB3 PLCB3 TGFBR1 TGFBR1 MYLK3 MYLK3 PIK3R5 PIK3R5 AGTR1 AGTR1 SMAD2 SMAD2 PLAT PLAT MEF2A MEF2A MAPK3 MAPK3 ITPR1 ITPR1 MYL2 MYL2 NRAS NRAS CAMK4 CAMK4 SMAD4 SMAD4 PLCB2 PLCB2 PRKCE PRKCE ADCY5 ADCY5 GABARAP GABARAP AKT2 AKT2 GNB5 GNB5 KRAS KRAS GNAQ GNAQ RRAS2 RRAS2 RYR3 RYR3 PIK3C3 PIK3C3 PLIN1 PLIN1 GNG2 GNG2 GNAI3 GNAI3 MYL4 MYL4 SLC9A1 SLC9A1 ADCY7 ADCY7 ADCY1 ADCY1 RAF1 RAF1 SPP1 SPP1 ADCY3 ADCY3 NOTCH3 NOTCH3 GNB4 GNB4 GNG10 GNG10 ITPR3 ITPR3 CALML6 CALML6 MTOR MTOR PRKAG1 PRKAG1 MRAS MRAS GNB1 GNB1 PRKAB2 PRKAB2 RYR1 RYR1 MAP2K2 MAP2K2 GNG3 GNG3 ADCY4 ADCY4 SERPINE1 SERPINE1 GABARAPL1 GABARAPL1 PPARGC1A PPARGC1A PRKAG2 PRKAG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MYL3Myosin light chain 3. (225 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CCN2Connective tissue growth factor. (349 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
MYLKMyosin light chain kinase. (1914 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (753 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
RYR2Ryanodine receptor 2. (4943 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
GNA13G protein subunit alpha 13. (377 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (443 aa)
ENSMFAP00000006047Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CALML4Calmodulin like 4. (193 aa)
TFAMTranscription factor A, mitochondrial. (248 aa)
SPHK2Sphingosine kinase 2. (653 aa)
GNAI1G protein subunit alpha i1. (422 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (750 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
RRASRAS related. (218 aa)
GNB3G protein subunit beta 3. (340 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
LIPEHormone-sensitive lipase. (1058 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
SPHK1Sphingosine kinase 1. (470 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1218 aa)
ADCY10Adenylate cyclase 10. (1562 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
NRF1Nuclear respiratory factor 1. (522 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PDE3BPhosphodiesterase. (1117 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
RPS640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (249 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MYLK3Myosin light chain kinase 3. (819 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
MYL2Myosin light chain 2. (166 aa)
NRASUncharacterized protein. (189 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNB5G protein subunit beta 5. (409 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GNAQG protein subunit alpha q. (359 aa)
RRAS2RAS related 2. (204 aa)
RYR3Ryanodine receptor 3. (4873 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
GNAI3G protein subunit alpha i3. (354 aa)
MYL4Myosin light chain 4. (195 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
NOTCH3Notch receptor 3. (2300 aa)
GNB4G protein subunit beta 4. (340 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CALML6Calmodulin like 6. (181 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKAG1Uncharacterized protein. (331 aa)
MRASUncharacterized protein. (208 aa)
GNB1G protein subunit beta 1. (340 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
RYR1Ryanodine receptor 1. (4309 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
GABARAPL1Uncharacterized protein. (146 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (16%) [HD]