STRINGSTRING
TGFB1 TGFB1 PIK3R3 PIK3R3 MAP2K1 MAP2K1 FYN FYN PIK3CD PIK3CD JUND JUND CSF1 CSF1 GRB2 GRB2 LOC102143631 LOC102143631 NFKB1 NFKB1 MAP3K14 MAP3K14 TNF TNF MAPK10 MAPK10 IFNGR2 IFNGR2 TEC TEC MAPK1 MAPK1 TGFB2 TGFB2 MAPK11 MAPK11 PIK3CB PIK3CB LILRA5 LILRA5 NCF2 NCF2 FCGR1A FCGR1A SOCS1 SOCS1 SOCS3 SOCS3 PPP3CC PPP3CC JUNB JUNB FOS FOS LILRA4 LILRA4 NFKBIA NFKBIA NFATC1 NFATC1 IFNB1 IFNB1 NFKB2 NFKB2 LCK LCK PPP3R1 PPP3R1 MAP2K7 MAP2K7 TREM2 TREM2 AKT1 AKT1 IKBKG IKBKG TAB1 TAB1 CYBA CYBA RELB RELB TNFSF11 TNFSF11 PPP3CB PPP3CB SQSTM1 SQSTM1 OSCAR OSCAR SYK SYK TRAF2 TRAF2 RELA RELA AKT3 AKT3 TNFRSF11A TNFRSF11A IL1A IL1A IL1B IL1B BTK BTK BLNK BLNK LOC102140945 LOC102140945 NOX1 NOX1 FOSL2 FOSL2 CYLD CYLD IFNAR1 IFNAR1 IFNG IFNG TYK2 TYK2 NFATC2 NFATC2 PIK3CA PIK3CA TGFBR1 TGFBR1 ACP5 ACP5 PIK3R1 PIK3R1 LOC102131997 LOC102131997 FOSL1 FOSL1 SIRPG SIRPG LOC102139733 LOC102139733 MAPK3 MAPK3 SIRPA SIRPA TNFRSF1A TNFRSF1A PLCG2 PLCG2 MAPK9 MAPK9 TAB2 TAB2 CAMK4 CAMK4 STAT2 STAT2 TNFRSF11B TNFRSF11B CALCR CALCR STAT1 STAT1 NCF4 NCF4 AKT2 AKT2 GAB2 GAB2 JAK1 JAK1 PPP3CA PPP3CA IFNGR1 IFNGR1 TGFBR2 TGFBR2 IL1R1 IL1R1 PPARG PPARG CSF1R CSF1R PIK3R2 PIK3R2 MAPK14 MAPK14 FOSB FOSB NCF1 NCF1 MAPK8 MAPK8 FCGR2B FCGR2B FHL2 FHL2 MITF MITF MAP3K7 MAP3K7 IKBKB IKBKB ITGB3 ITGB3 TRAF6 TRAF6 MAP2K6 MAP2K6 IFNAR2 IFNAR2 CREB1 CREB1 LCP2 LCP2 CTSK CTSK CHUK CHUK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (325 aa)
CSF1Colony stimulating factor 1. (587 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
LOC102143631Uncharacterized protein. (484 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
IFNGR2Interferon gamma receptor 2. (336 aa)
TECTyrosine-protein kinase. (630 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
LILRA5Leukocyte immunoglobulin like receptor A5. (299 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
FCGR1AUncharacterized protein. (375 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LILRA4Leukocyte immunoglobulin like receptor A4. (499 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
NFATC1Nuclear factor of activated T cells 1. (812 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (187 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
LCKTyrosine-protein kinase. (342 aa)
PPP3R1Uncharacterized protein. (189 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
RELBRELB proto-oncogene, NF-kB subunit. (526 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
SQSTM1Sequestosome 1. (440 aa)
OSCAROsteoclast associated Ig-like receptor. (238 aa)
SYKTyrosine-protein kinase. (635 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
TNFRSF11ATNF receptor superfamily member 11a. (615 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (271 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
BTKTyrosine-protein kinase. (659 aa)
BLNKB cell linker. (456 aa)
LOC102140945Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Binds IgG1 and IgG2 (By similarity). (277 aa)
NOX1NADPH oxidase 1. (564 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (477 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC102131997Uncharacterized protein. (481 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
SIRPGSignal regulatory protein gamma. (387 aa)
LOC102139733Uncharacterized protein. (397 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
SIRPAUncharacterized protein. (507 aa)
TNFRSF1AUncharacterized protein. (455 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
TNFRSF11BTNF receptor superfamily member 11b. (428 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (517 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GAB2GRB2 associated binding protein 2. (677 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IFNGR1Uncharacterized protein. (488 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (991 aa)
PIK3R2Uncharacterized protein. (694 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FCGR2BUncharacterized protein. (317 aa)
FHL2Four and a half LIM domains 2. (389 aa)
MITFMelanocyte inducing transcription factor. (519 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa)
IFNAR2Uncharacterized protein. (735 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (329 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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