STRINGSTRING
PIK3R3 PIK3R3 MAP2K1 MAP2K1 WNT9B WNT9B DVL3 DVL3 PIK3CD PIK3CD FGFR2 FGFR2 HRAS HRAS AXIN2 AXIN2 ID2 ID2 GRB2 GRB2 IL6ST IL6ST LEFTY1 LEFTY1 HOXB1 HOXB1 STAT3 STAT3 SMAD3 SMAD3 PCGF6 PCGF6 ESX1 ESX1 MAPK1 MAPK1 AXIN1 AXIN1 WNT2B WNT2B MAPK11 MAPK11 BMPR1A BMPR1A GSK3B GSK3B PIK3CB PIK3CB MEIS1 MEIS1 PCGF5 PCGF5 CTNNB1 CTNNB1 PCGF2 PCGF2 BMP4 BMP4 FZD6 FZD6 PCGF3 PCGF3 FGF2 FGF2 ESRRB ESRRB POU5F1 POU5F1 LIF LIF ONECUT1 ONECUT1 ENSMFAP00000011315 ENSMFAP00000011315 FZD5 FZD5 NEUROG1 NEUROG1 FZD9 FZD9 FZD10 FZD10 PAX6 PAX6 ZIC3 ZIC3 SOX2 SOX2 SKIL SKIL WNT3 WNT3 FZD7 FZD7 IGF1 IGF1 WNT16 WNT16 OTX1 OTX1 AKT1 AKT1 ACVR1B ACVR1B RIF1 RIF1 BMPR2 BMPR2 FGFR3 FGFR3 INHBC INHBC TCF3 TCF3 FGFR4 FGFR4 AKT3 AKT3 WNT8B WNT8B DVL1 DVL1 INHBE INHBE KLF4 KLF4 DLX5 DLX5 ISL1 ISL1 INHBB INHBB WNT11 WNT11 WNT6 WNT6 WNT10B WNT10B WNT7B WNT7B WNT2 WNT2 FZD3 FZD3 WNT7A WNT7A TCF7 TCF7 PIK3CA PIK3CA WNT8A WNT8A PIK3R1 PIK3R1 WNT3A WNT3A ID3 ID3 SMAD2 SMAD2 MYF5 MYF5 MAPK3 MAPK3 ACVR1C ACVR1C ACVR1 ACVR1 SETDB1 SETDB1 SMARCAD1 SMARCAD1 LHX5 LHX5 NRAS NRAS JARID2 JARID2 BMPR1B BMPR1B SMAD4 SMAD4 IGF1R IGF1R APC2 APC2 ACVR2A ACVR2A AKT2 AKT2 JAK1 JAK1 ID1 ID1 JAK2 JAK2 KRAS KRAS HESX1 HESX1 PCGF1 PCGF1 WNT10A WNT10A WNT5A WNT5A ZFHX3 ZFHX3 HOXA1 HOXA1 JAK3 JAK3 FZD4 FZD4 PIK3R2 PIK3R2 WNT1 WNT1 FGFR1 FGFR1 SMAD1 SMAD1 MAPK14 MAPK14 INHBA INHBA RAF1 RAF1 BMI1 BMI1 LIFR LIFR FZD2 FZD2 REST REST WNT4 WNT4 HOXD1 HOXD1 DUSP9 DUSP9 ACVR2B ACVR2B APC APC NANOG NANOG NODAL NODAL WNT5B WNT5B MYC MYC KAT6A KAT6A MAP2K2 MAP2K2 WNT9A WNT9A SMAD5 SMAD5 LOC102144954 LOC102144954 TBX3 TBX3 DVL2 DVL2 FZD8 FZD8 HAND1 HAND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AXIN2Axin 2. (844 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
IL6STInterleukin 6 signal transducer. (942 aa)
LEFTY1Left-right determination factor. (366 aa)
HOXB1Homeobox B1. (304 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PCGF6Polycomb group ring finger 6. (350 aa)
ESX1ESX homeobox 1. (361 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
AXIN1Axin 1. (867 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
MEIS1Meis homeobox 1. (465 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
CTNNB1Catenin beta 1. (781 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ESRRBEstrogen related receptor beta. (438 aa)
POU5F1POU domain protein. (360 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
ONECUT1One cut domain family member. (465 aa)
ENSMFAP00000011315Homeobox domain-containing protein. (264 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
NEUROG1Neurogenin 1. (237 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
PAX6Uncharacterized protein. (462 aa)
ZIC3Zic family member 3. (488 aa)
SOX2SRY-box transcription factor 2. (319 aa)
SKILSKI like proto-oncogene. (684 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
IGF1Insulin like growth factor 1. (159 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
OTX1Orthodenticle homeobox 1. (354 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
INHBCInhibin subunit beta C. (352 aa)
TCF3Transcription factor 3. (654 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
DVL1Dishevelled segment polarity protein 1. (673 aa)
INHBEInhibin subunit beta E. (351 aa)
KLF4Testis cDNA clone: QtsA-19426, similar to human Kruppel-like factor 4 (gut) (KLF4). (479 aa)
DLX5Distal-less homeobox 5. (289 aa)
ISL1ISL LIM homeobox 1. (349 aa)
INHBBInhibin subunit beta B. (360 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
TCF7Transcription factor 7. (398 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (488 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1291 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
LHX5LIM homeobox 5. (402 aa)
NRASUncharacterized protein. (189 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1200 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HESX1HESX homeobox 1. (185 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ZFHX3Zinc finger homeobox 3. (3699 aa)
HOXA1Homeobox A1. (335 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (524 aa)
PIK3R2Uncharacterized protein. (694 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
INHBAInhibin subunit beta A. (426 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
BMI1RING-type domain-containing protein. (326 aa)
LIFRLIF receptor subunit alpha. (1097 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (562 aa)
RESTRE1 silencing transcription factor. (1095 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
HOXD1Homeobox D1. (327 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
APCAPC regulator of WNT signaling pathway. (2861 aa)
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (280 aa)
NODALNodal growth differentiation factor. (347 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
LOC102144954Left-right determination factor. (366 aa)
TBX3T-box transcription factor 3. (743 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.