STRINGSTRING
C8B C8B F5 F5 PLG PLG F13B F13B SERPING1 SERPING1 VSIG4 VSIG4 FGG FGG C2 C2 C5 C5 ITGB2 ITGB2 C8A C8A F13A1 F13A1 ENSMFAP00000008465 ENSMFAP00000008465 C4BPA C4BPA TFPI TFPI BDKRB2 BDKRB2 MASP2 MASP2 CR2 CR2 SERPIND1 SERPIND1 ITGAM ITGAM SERPINC1 SERPINC1 F2 F2 MBL2 MBL2 CFI CFI F12 F12 ITGAX ITGAX CD59 CD59 VTN VTN F7 F7 SERPINB2 SERPINB2 LOC102135038 LOC102135038 SERPINA1 SERPINA1 PROS1 PROS1 F10 F10 PLAUR PLAUR F2R F2R C3 C3 PROC PROC C1S C1S F9 F9 FGB FGB FGA FGA KLKB1 KLKB1 F11 F11 F3 F3 PLAT PLAT C6 C6 PROCR PROCR C7 C7 LOC102132156 LOC102132156 CD46 CD46 A2M A2M CFHR5 CFHR5 F2RL3 F2RL3 C1QA C1QA SERPINA5 SERPINA5 C1QB C1QB PLAU PLAU SERPINF2 SERPINF2 C1QC C1QC F2RL2 F2RL2 C1R C1R KNG1 KNG1 C8G C8G F8 F8 CFH-2 CFH-2 CPB2 CPB2 C4BPB C4BPB CD55 CD55 C9 C9 VWF VWF CFD CFD SERPINE1 SERPINE1 CR1L CR1L ENSMFAP00000045703 ENSMFAP00000045703
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C8BComplement C8 beta chain. (591 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2181 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (811 aa)
F13BCoagulation factor XIII B chain. (661 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (500 aa)
VSIG4V-set and immunoglobulin domain containing 4. (404 aa)
FGGFibrinogen gamma chain. (453 aa)
C2Uncharacterized protein; Belongs to the peptidase S1 family. (1112 aa)
C5Complement C5. (1676 aa)
ITGB2Integrin beta. (874 aa)
C8AComplement C8 alpha chain. (584 aa)
F13A1Coagulation factor XIII A chain. (732 aa)
ENSMFAP00000008465C-type lectin domain-containing protein. (249 aa)
C4BPAComplement component 4 binding protein alpha. (623 aa)
TFPITissue factor pathway inhibitor. (304 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
MASP2Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
CR2Complement C3d receptor 2. (1093 aa)
SERPIND1Serpin family D member 1; Belongs to the serpin family. (499 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1147 aa)
SERPINC1Serpin family C member 1; Belongs to the serpin family. (464 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (620 aa)
MBL2Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (255 aa)
CFIUncharacterized protein. (161 aa)
F12Coagulation factor XII. (615 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1168 aa)
CD59CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity). (130 aa)
VTNSMB domain-containing protein. (479 aa)
F7Coagulation factor VII. (472 aa)
SERPINB2Serpin family B member 2; Belongs to the serpin family. (415 aa)
LOC102135038Uncharacterized protein; Belongs to the peptidase S1 family. (664 aa)
SERPINA1Serpin family A member 1; Belongs to the serpin family. (418 aa)
PROS1Protein S. (676 aa)
F10Coagulation factor X. (488 aa)
PLAURUrokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). (335 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
C3Complement C3. (1663 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (462 aa)
C1SUncharacterized protein; Belongs to the peptidase S1 family. (688 aa)
F9Coagulation factor IX. (461 aa)
FGBFibrinogen beta chain. (491 aa)
FGAFibrinogen alpha chain. (928 aa)
KLKB1Kallikrein B1; Belongs to the peptidase S1 family. (638 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (625 aa)
F3Coagulation factor III, tissue factor. (296 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
C6Complement C6. (934 aa)
PROCRProtein C receptor. (238 aa)
C7Complement C7. (843 aa)
LOC102132156Uncharacterized protein. (1744 aa)
CD46CD46 molecule. (399 aa)
A2MAlpha-2-macroglobulin. (1474 aa)
CFHR5Complement factor H related 5. (577 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (385 aa)
C1QAComplement C1q A chain. (245 aa)
SERPINA5Serpin family A member 5; Belongs to the serpin family. (477 aa)
C1QBComplement C1q B chain. (253 aa)
PLAUPlasminogen activator, urokinase. (430 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
C1QCComplement C1q C chain. (245 aa)
F2RL2Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
C1RComplement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. (698 aa)
KNG1Kininogen 1. (644 aa)
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2351 aa)
CFH-2Uncharacterized protein. (1235 aa)
CPB2Carboxypeptidase B2. (423 aa)
C4BPBComplement component 4 binding protein beta. (252 aa)
CD55CD55 molecule (Cromer blood group). (541 aa)
C9Complement C9. (561 aa)
VWFVon Willebrand factor. (2813 aa)
CFDComplement factor D; Belongs to the peptidase S1 family. (253 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
CR1LComplement C3b/C4b receptor 1 like. (568 aa)
ENSMFAP00000045703Uncharacterized protein; Belongs to the peptidase S1 family. (687 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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