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| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (1044 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (535 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) |
| | ENSMFAP00000002130 | DEFENSIN domain-containing protein. (94 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | ATG16L1 | Autophagy related 16 like 1. (624 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | RHOA | Uncharacterized protein. (141 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | TXN | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | LOC102138104 | Uncharacterized protein. (426 aa) |
| | STING1 | Stimulator of interferon protein. (379 aa) |
| | LOC102141352 | Uncharacterized protein. (198 aa) |
| | NLRX1 | NLR family member X1. (972 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | PANX1 | Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa) |
| | GSDMD | Gasdermin D. (518 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | CASP5 | Caspase 5; Belongs to the peptidase C14A family. (462 aa) |
| | VDAC1 | Uncharacterized protein. (289 aa) |
| | TANK | TRAF family member associated NFKB activator. (425 aa) |
| | CXCL2 | C-X-C motif chemokine. (107 aa) |
| | CYBB | Cytochrome b-245 beta chain. (570 aa) |
| | LOC102141744 | Uncharacterized protein. (198 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (404 aa) |
| | LOC102119017 | Uncharacterized protein. (67 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (687 aa) |
| | CXCL3 | C-X-C motif chemokine. (107 aa) |
| | DNM1L | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa) |
| | BCL2 | BCL2 apoptosis regulator. (242 aa) |
| | LOC102140303 | Uncharacterized protein. (190 aa) |
| | CTSB | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. (339 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (488 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | GBP2 | Guanylate binding protein 2. (591 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | NAMPT | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (187 aa) |
| | LOC102146717 | Uncharacterized protein. (189 aa) |
| | PYDC2 | Pyrin domain containing 2. (139 aa) |
| | ENSMFAP00000014199 | HATPase_c domain-containing protein. (307 aa) |
| | PKN2 | Protein kinase N2. (983 aa) |
| | ENSMFAP00000014845 | DEFSN domain-containing protein. (64 aa) |
| | TRPV2 | Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa) |
| | LOC101925999 | Uncharacterized protein. (455 aa) |
| | BRCC3 | MPN domain-containing protein. (297 aa) |
| | CCL5 | C-C motif chemokine. (91 aa) |
| | AIM2 | Absent in melanoma 2. (348 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | TRPM7 | Transient receptor potential cation channel subfamily M member 7. (1848 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | CYBA | Cytochrome b-245 alpha chain. (197 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | ERBIN | Erbb2 interacting protein. (1418 aa) |
| | CAMP | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. (173 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | LOC102126320 | DEFENSIN domain-containing protein. (94 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | LOC102116444 | Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | TRIP6 | Thyroid hormone receptor interactor 6. (476 aa) |
| | MCU | Mitochondrial calcium uniporter. (351 aa) |
| | CASP4 | Caspase 4; Belongs to the peptidase C14A family. (377 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | LOC102117659 | DEFENSIN domain-containing protein. (96 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (477 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | CARD17 | CARD domain-containing protein. (128 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa) |
| | ANTXR1 | Anthrax toxin receptor; Belongs to the ATR family. (564 aa) |
| | GBP7 | Guanylate binding protein 7. (638 aa) |
| | NLRP12 | NLR family pyrin domain containing 12. (962 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | TYK2 | Tyrosine-protein kinase. (1190 aa) |
| | CXCL3-2 | C-X-C motif chemokine. (107 aa) |
| | RNASEL | Ribonuclease L. (741 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa) |
| | MFN2 | Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | IFI16 | Interferon gamma inducible protein 16. (729 aa) |
| | VDAC3 | Voltage dependent anion channel 3. (284 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa) |
| | NEK7 | NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa) |
| | DHX33 | DEAH-box helicase 33. (707 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (398 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (657 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | STAT2 | Signal transducer and activator of transcription. (851 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (831 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | GABARAP | GABA type A receptor-associated protein. (117 aa) |
| | JAK1 | Tyrosine-protein kinase. (1159 aa) |
| | LOC102125546 | DEFENSIN domain-containing protein. (94 aa) |
| | NLRP7 | NLR family pyrin domain containing 7. (1037 aa) |
| | MFN1 | Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (741 aa) |
| | PKN1 | Protein kinase N1. (949 aa) |
| | CARD6 | Caspase recruitment domain family member 6. (1037 aa) |
| | GBP3 | Guanylate binding protein 3. (595 aa) |
| | TXN2 | Thioredoxin 2. (196 aa) |
| | LOC102116064 | Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1117 aa) |
| | GPRC6A | G protein-coupled receptor class C group 6 member A. (928 aa) |
| | CXCL1L | C-X-C motif chemokine. (154 aa) |
| | CARD18 | Caspase recruitment domain family member 18. (100 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | ENSMFAP00000037625 | DEFSN domain-containing protein. (64 aa) |
| | LOC102116821 | Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1035 aa) |
| | HSP90AB1 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (381 aa) |
| | VDAC2 | Uncharacterized protein. (308 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (541 aa) |
| | ANTXR2 | Anthrax toxin receptor; Belongs to the ATR family. (488 aa) |
| | DEFA6 | Defensin alpha 6. (100 aa) |
| | TXNIP | Thioredoxin interacting protein. (391 aa) |
| | ENSMFAP00000040719 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa) |
| | PSTPIP1 | Proline-serine-threonine phosphatase interacting protein 1. (413 aa) |
| | MEFV | MEFV innate immuity regulator, pyrin. (785 aa) |
| | IRF7 | Interferon regulatory factor 7. (504 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | CASR | Calcium sensing receptor. (1078 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa) |
| | GBP1 | Guanylate binding protein 1. (590 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (497 aa) |
| | RNF31 | Uncharacterized protein. (1072 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa) |
| | CARD16 | CARD domain-containing protein. (97 aa) |
| | NAIP | NLR family apoptosis inhibitory protein. (1403 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1088 aa) |
| | IFNAR2 | Uncharacterized protein. (735 aa) |
| | CXCL1 | C-X-C motif chemokine. (107 aa) |
| | GABARAPL1 | Uncharacterized protein. (146 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa) |
| | LOC102125912 | DEFENSIN domain-containing protein. (94 aa) |
| | LOC102118641 | Defensin_propep domain-containing protein. (97 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in [...] (790 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
