STRINGSTRING
PIK3R3 PIK3R3 PIK3CD PIK3CD BCAR1 BCAR1 RHOA RHOA CDH5 CDH5 ACTN4 ACTN4 PTK2 PTK2 MAPK11 MAPK11 PIK3CB PIK3CB CYBB CYBB ITGB2 ITGB2 THY1 THY1 CTNNB1 CTNNB1 NCF2 NCF2 ITGA4 ITGA4 GNAI1 GNAI1 CLDN9 CLDN9 CLDN24 CLDN24 RHOH RHOH CLDN22 CLDN22 CLDN10 CLDN10 CLDN19 CLDN19 CLDN17 CLDN17 CLDN20 CLDN20 CLDN4 CLDN4 ICAM1 ICAM1 CLDN5 CLDN5 CLDN3 CLDN3 PRKCA PRKCA VCAM1 VCAM1 CLDN14 CLDN14 CLDN8 CLDN8 CLDN2 CLDN2 VAV3 VAV3 PRKCB PRKCB MMP9 MMP9 ITGAM ITGAM PXN PXN CTNND1 CTNND1 ACTB ACTB CYBA CYBA CDC42 CDC42 GNAI2 GNAI2 SIPA1 SIPA1 MYL5 MYL5 CLDN16 CLDN16 ROCK2 ROCK2 CD99L2 CD99L2 RAPGEF4 RAPGEF4 VCL VCL PIK3CA PIK3CA PIK3R1 PIK3R1 CLDN18 CLDN18 RASSF5 RASSF5 PLCG2 PLCG2 JAM2 JAM2 PRKCG PRKCG CTNNA3 CTNNA3 PECAM1 PECAM1 MYL2 MYL2 VASP VASP MYL12A MYL12A CXCR4 CXCR4 MMP2 MMP2 EZR EZR ITGAL ITGAL NCF4 NCF4 ACTN1 ACTN1 ROCK1 ROCK1 PTK2B PTK2B MSN MSN VAV2 VAV2 CTNNA2 CTNNA2 RAP1A RAP1A RAPGEF3 RAPGEF3 PIK3R2 PIK3R2 OCLN OCLN ITGB1 ITGB1 GNAI3 GNAI3 MAPK14 MAPK14 NCF1 NCF1 MYL7 MYL7 RAP1B RAP1B F11R F11R PTPN11 PTPN11 CLDN7 CLDN7 CTNNA1 CTNNA1 ARHGAP35 ARHGAP35 CLDN1 CLDN1 CXCL12 CXCL12 VAV1 VAV1 MYLPF MYLPF CLDN11 CLDN11 CLDN15 CLDN15 TXK TXK ARHGAP5 ARHGAP5 PLCG1 PLCG1 CD99 CD99 RAC2 RAC2 MYL9 MYL9 ITK ITK ESAM ESAM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
RHOAUncharacterized protein. (141 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
ACTN4Actinin alpha 4. (931 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
ITGB2Integrin beta. (874 aa)
THY1Thy-1 cell surface antigen. (161 aa)
CTNNB1Catenin beta 1. (781 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
GNAI1G protein subunit alpha i1. (422 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
RHOHRas homolog family member H. (191 aa)
CLDN22Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1147 aa)
PXNPaxillin. (1079 aa)
CTNND1Catenin delta 1. (968 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (379 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
SIPA1Signal-induced proliferation-associated 1. (1042 aa)
MYL5Myosin light chain 5. (175 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
CD99L2CD99 molecule like 2. (267 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
VCLUncharacterized protein. (80 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
RASSF5Ras association domain family member 5. (418 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
JAM2Junctional adhesion molecule 2. (311 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
CTNNA3Catenin alpha 3. (895 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (738 aa)
MYL2Myosin light chain 2. (166 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (378 aa)
MYL12AMyosin light chain 12A. (177 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (408 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
EZREzrin. (586 aa)
ITGALVWFA domain-containing protein. (582 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
ACTN1Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
MSNMoesin. (581 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
CTNNA2Catenin alpha 2. (953 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
PIK3R2Uncharacterized protein. (694 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (546 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
GNAI3G protein subunit alpha i3. (354 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
MYL7Myosin light chain 7. (175 aa)
RAP1BRas-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
F11RJunctional adhesion molecule 1. (299 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CTNNA1Catenin alpha 1. (906 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (169 aa)
CLDN11Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. (207 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
TXKTyrosine-protein kinase. (527 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CD99CD99 molecule (Xg blood group). (182 aa)
RAC2Rac family small GTPase 2. (192 aa)
MYL9Myosin light chain 9. (172 aa)
ITKTyrosine-protein kinase. (620 aa)
ESAMEndothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction. (390 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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