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CACNA1S CACNA1S PIK3R3 PIK3R3 MAP2K1 MAP2K1 FYN FYN PIK3CD PIK3CD HRAS HRAS PLCB4 PLCB4 ADCY6 ADCY6 SLC5A7 SLC5A7 CREB5 CREB5 GNGT1 GNGT1 ADCY8 ADCY8 ADCY2 ADCY2 MAPK1 MAPK1 CHRNA3 CHRNA3 ENSMFAP00000006047 ENSMFAP00000006047 GNG4 GNG4 PIK3CB PIK3CB CAMK2D CAMK2D CHRNA7 CHRNA7 GNAI1 GNAI1 GNGT2 GNGT2 KCNQ3 KCNQ3 PIK3R6 PIK3R6 PRKACA PRKACA CACNA1B CACNA1B BCL2 BCL2 SLC18A3 SLC18A3 KCNJ2 KCNJ2 CHRM5 CHRM5 FOS FOS CHRM4 CHRM4 CHRNA6 CHRNA6 PRKCA PRKCA CHRM1 CHRM1 CHRM2 CHRM2 GNB3 GNB3 KCNJ12 KCNJ12 GNG5 GNG5 PRKACG PRKACG PRKCB PRKCB CREB3L1 CREB3L1 AKT1 AKT1 GNAI2 GNAI2 PIK3CG PIK3CG AKT3 AKT3 GNG11 GNG11 ITPR2 ITPR2 CREB3L2 CREB3L2 KCNJ3 KCNJ3 CAMK2A CAMK2A GNG12 GNG12 PLCB1 PLCB1 KCNQ1 KCNQ1 CHRNB4 CHRNB4 PRKACB PRKACB CREB3 CREB3 PLCB3 PLCB3 PIK3CA PIK3CA CHAT CHAT PIK3R1 PIK3R1 KCNJ14 KCNJ14 PIK3R5 PIK3R5 MAPK3 MAPK3 PRKCG PRKCG ITPR1 ITPR1 CACNA1F CACNA1F NRAS NRAS CAMK4 CAMK4 KCNQ2 KCNQ2 KCNQ5 KCNQ5 PLCB2 PLCB2 CHRNB2 CHRNB2 KCNJ4 KCNJ4 ADCY5 ADCY5 AKT2 AKT2 GNB5 GNB5 JAK2 JAK2 KRAS KRAS GNAQ GNAQ KCNQ4 KCNQ4 PIK3R2 PIK3R2 GNG2 GNG2 GNAI3 GNAI3 ACHE ACHE ADCY7 ADCY7 ADCY1 ADCY1 ADCY3 ADCY3 GNA11 GNA11 GNB4 GNB4 GNG10 GNG10 ITPR3 ITPR3 CREB3L3 CREB3L3 GNB1 GNB1 GNG3 GNG3 CACNA1A CACNA1A CACNA1D CACNA1D CREB1 CREB1 ADCY4 ADCY4 KCNJ6 KCNJ6 CHRNA4 CHRNA4 ATF4 ATF4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (497 aa)
ENSMFAP00000006047Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
CHRNA7Uncharacterized protein. (510 aa)
GNAI1G protein subunit alpha i1. (422 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (872 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (750 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2277 aa)
BCL2BCL2 apoptosis regulator. (242 aa)
SLC18A3Solute carrier family 18 member A3. (532 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (479 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
GNB3G protein subunit beta 3. (340 aa)
KCNJ12Uncharacterized protein. (433 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (644 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (492 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (631 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (436 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
NRASUncharacterized protein. (189 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (872 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5. (951 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (445 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNB5G protein subunit beta 5. (409 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GNAQG protein subunit alpha q. (359 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (652 aa)
PIK3R2Uncharacterized protein. (694 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (631 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
GNA11G protein subunit alpha 11. (359 aa)
GNB4G protein subunit beta 4. (340 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (301 aa)
GNB1G protein subunit beta 1. (340 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2370 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (626 aa)
ATF4Activating transcription factor 4. (351 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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