STRINGSTRING
PIK3R3 PIK3R3 PIK3CD PIK3CD PTGER4 PTGER4 PLCB4 PLCB4 ADCY6 ADCY6 ADCY8 ADCY8 MAPK10 MAPK10 ADCY2 ADCY2 ASIC3 ASIC3 PPP1CA PPP1CA MAPK11 MAPK11 CALM3 CALM3 PIK3CB PIK3CB CALML4 CALML4 TRPV1 TRPV1 CAMK2D CAMK2D PTGER2 PTGER2 ASIC1 ASIC1 ENSMFAP00000009633 ENSMFAP00000009633 HTR2C HTR2C PRKACA PRKACA CALML3 CALML3 BDKRB2 BDKRB2 PRKCA PRKCA P2RY2 P2RY2 PRKCH PRKCH HRH1 HRH1 PRKACG PRKACG NTRK1 NTRK1 IGF1 IGF1 TRPV2 TRPV2 PRKCB PRKCB TRPV4 TRPV4 SRC SRC CYP4A11 CYP4A11 ITPR2 ITPR2 PLA2G4B PLA2G4B HTR2A HTR2A IL1B IL1B CAMK2A CAMK2A PPP1CB PPP1CB PLCB1 PLCB1 TRPM8 TRPM8 GNAS GNAS PLA2G4A PLA2G4A PRKACB PRKACB ASIC5 ASIC5 PLCB3 PLCB3 PIK3CA PIK3CA TRPA1 TRPA1 PIK3R1 PIK3R1 PLA2G4E PLA2G4E PLCG2 PLCG2 MAPK9 MAPK9 PRKCG PRKCG ITPR1 ITPR1 PLCB2 PLCB2 PRKCE PRKCE ADCY5 ADCY5 CYP2J2 CYP2J2 HTR2B HTR2B GNAQ GNAQ PLA2G4D PLA2G4D NGF NGF IL1R1 IL1R1 PIK3R2 PIK3R2 F2RL1 F2RL1 ADCY7 ADCY7 MAP2K3 MAP2K3 MAPK14 MAPK14 PPP1CC PPP1CC ADCY1 ADCY1 MAPK8 MAPK8 PRKCQ PRKCQ PLA2G4F PLA2G4F ADCY3 ADCY3 ASIC4 ASIC4 PLA2G6 PLA2G6 KNG1 KNG1 ITPR3 ITPR3 CALML6 CALML6 MAP2K6 MAP2K6 ALOX12 ALOX12 IL1RAP IL1RAP ADCY4 ADCY4 PRKCD PRKCD PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PTGER4Prostaglandin E2 subtype EP4 receptor; Belongs to the G-protein coupled receptor 1 family. (490 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (541 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
CALML4Calmodulin like 4. (193 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (562 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
HRH1Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (487 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
NTRK1Tyrosine-protein kinase receptor. (816 aa)
IGF1Insulin like growth factor 1. (159 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (823 aa)
SRCTyrosine-protein kinase. (542 aa)
CYP4A11Uncharacterized protein; Belongs to the cytochrome P450 family. (519 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
PLA2G4BPhospholipase A2. (781 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1104 aa)
GNASGNAS complex locus. (1023 aa)
PLA2G4APhospholipase A2. (749 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ASIC5Acid sensing ion channel subunit family member 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (505 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PLA2G4EPhospholipase A2. (869 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
CYP2J2Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
GNAQG protein subunit alpha q. (359 aa)
PLA2G4DPhospholipase A2. (817 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
PIK3R2Uncharacterized protein. (694 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PLA2G4FPhospholipase A2. (849 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ASIC4Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (666 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
KNG1Kininogen 1. (644 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CALML6Calmodulin like 6. (181 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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