STRINGSTRING
CACNA1S CACNA1S MAP2K1 MAP2K1 HRAS HRAS GRB2 GRB2 PLCB4 PLCB4 ADCY6 ADCY6 MMP14 MMP14 ADCY8 ADCY8 MAPK10 MAPK10 ADCY2 ADCY2 MAPK1 MAPK1 MAPK11 MAPK11 CALM3 CALM3 CALML4 CALML4 SOS2 SOS2 CAMK2D CAMK2D MAP3K4 MAP3K4 ENSMFAP00000009633 ENSMFAP00000009633 PRKACA PRKACA CALML3 CALML3 MAP3K1 MAP3K1 ENSMFAP00000011401 ENSMFAP00000011401 PRKCA PRKCA EGR1 EGR1 PRKACG PRKACG PRKCB PRKCB SOS1 SOS1 MAP2K7 MAP2K7 SRC SRC CDC42 CDC42 MAP3K3 MAP3K3 ITPR2 ITPR2 PLA2G4B PLA2G4B CAMK2A CAMK2A PLCB1 PLCB1 GNAS GNAS HBEGF HBEGF PLA2G4A PLA2G4A PRKACB PRKACB GNRH1 GNRH1 PLCB3 PLCB3 PLA2G4E PLA2G4E MAPK7 MAPK7 MAPK3 MAPK3 MAPK9 MAPK9 ITPR1 ITPR1 CACNA1F CACNA1F NRAS NRAS MMP2 MMP2 PLCB2 PLCB2 LHB LHB PLD1 PLD1 PLD2 PLD2 ADCY5 ADCY5 KRAS KRAS PTK2B PTK2B GNAQ GNAQ PLA2G4D PLA2G4D GNRH2 GNRH2 GNRHR GNRHR MAP3K2 MAP3K2 ADCY7 ADCY7 MAP2K3 MAP2K3 MAPK14 MAPK14 EGFR EGFR ADCY1 ADCY1 RAF1 RAF1 MAPK8 MAPK8 PLA2G4F PLA2G4F ADCY3 ADCY3 MAP2K4 MAP2K4 GNA11 GNA11 FSHB FSHB ITPR3 ITPR3 CALML6 CALML6 ELK1 ELK1 MAP2K6 MAP2K6 MAP2K2 MAP2K2 CACNA1D CACNA1D ENSMFAP00000044507 ENSMFAP00000044507 ADCY4 ADCY4 ATF4 ATF4 PRKCD PRKCD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CALML4Calmodulin like 4. (193 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1604 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1683 aa)
ENSMFAP00000011401ETS domain-containing protein. (426 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
SRCTyrosine-protein kinase. (542 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
PLA2G4BPhospholipase A2. (781 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNASGNAS complex locus. (1023 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PLA2G4APhospholipase A2. (749 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
PLA2G4EPhospholipase A2. (869 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
NRASUncharacterized protein. (189 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
LHBLutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (157 aa)
PLD1Phospholipase. (1074 aa)
PLD2Phospholipase. (933 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
GNAQG protein subunit alpha q. (359 aa)
PLA2G4DPhospholipase A2. (817 aa)
GNRH2Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (114 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (619 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PLA2G4FPhospholipase A2. (849 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
GNA11G protein subunit alpha 11. (359 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs (By similarity). (129 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CALML6Calmodulin like 6. (181 aa)
ELK1ETS domain-containing protein Elk-1. (428 aa)
MAP2K6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ENSMFAP00000044507G_PROTEIN_RECEP_F1_2 domain-containing protein. (379 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
ATF4Activating transcription factor 4. (351 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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