91 items (Macaca fascicularis) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	DVL3	Dishevelled segment polarity protein 3. (718 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
	CALM3	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	CALML4	Calmodulin like 4. (193 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	EDN1	Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (211 aa)
	CAMK2D	Protein kinase domain-containing protein. (533 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
	GNAI1	G protein subunit alpha i1. (422 aa)
	ENSMFAP00000009633	Uncharacterized protein. (245 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	FZD9	Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
	ASIP	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). (132 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	GNAI2	Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
	WNT8B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	DVL1	Dishevelled segment polarity protein 1. (673 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	TCF7L1	Transcription factor 7 like 1. (589 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
	TCF7L2	Transcription factor 7 like 2. (542 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	GNAS	GNAS complex locus. (1023 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	WNT7A	Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
	CREB3	cAMP responsive element binding protein 3. (372 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
	TCF7	Transcription factor 7. (398 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	TYR	Tyrosinase. (530 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	MAPK3	Mitogen-activated protein kinase. (322 aa)
	PRKCG	Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
	NRAS	Uncharacterized protein. (189 aa)
	MC1R	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (524 aa)
	CREBBP	CREB binding protein. (2442 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (562 aa)
	MITF	Melanocyte inducing transcription factor. (519 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	TYRP1	Tyrosinase related protein 1. (537 aa)
	CALML6	Calmodulin like 6. (181 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (301 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	EP300	E1A binding protein p300. (2414 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
	POMC	Proopiomelanocortin. (265 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSMFAP00000037635	ENSMFAP00000003902	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.479
ADCY1	ADCY3	ENSMFAP00000037635	ENSMFAP00000038297	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.948
ADCY1	ADCY4	ENSMFAP00000037635	ENSMFAP00000044710	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.467
ADCY1	ADCY5	ENSMFAP00000037635	ENSMFAP00000033517	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.479
ADCY1	ADCY6	ENSMFAP00000037635	ENSMFAP00000001986	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.455
ADCY1	ADCY7	ENSMFAP00000037635	ENSMFAP00000037325	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.507
ADCY1	ADCY8	ENSMFAP00000037635	ENSMFAP00000003231	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY1	CALM3	ENSMFAP00000037635	ENSMFAP00000006312	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.969
ADCY1	CALML3	ENSMFAP00000037635	ENSMFAP00000010575	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.948
ADCY1	CALML4	ENSMFAP00000037635	ENSMFAP00000006731	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.936
ADCY1	CALML6	ENSMFAP00000037635	ENSMFAP00000042193	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.938
ADCY1	CAMK2A	ENSMFAP00000037635	ENSMFAP00000022790	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.699
ADCY1	CAMK2D	ENSMFAP00000037635	ENSMFAP00000007678	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.699
ADCY1	ENSMFAP00000009633	ENSMFAP00000037635	ENSMFAP00000009633	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.901
ADCY1	GNAI1	ENSMFAP00000037635	ENSMFAP00000008751	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.813
ADCY1	GNAI2	ENSMFAP00000037635	ENSMFAP00000019540	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily.	0.806
ADCY1	GNAI3	ENSMFAP00000037635	ENSMFAP00000037022	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.813
ADCY1	GNAS	ENSMFAP00000037635	ENSMFAP00000024110	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.971
ADCY1	PRKACA	ENSMFAP00000037635	ENSMFAP00000009922	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.927
ADCY1	PRKACB	ENSMFAP00000037635	ENSMFAP00000025214	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.930

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