STRINGSTRING
ADIPOR2 ADIPOR2 PRKAA1 PRKAA1 NFKB1 NFKB1 STAT3 STAT3 TNF TNF MAPK10 MAPK10 G6PC2 G6PC2 RXRG RXRG PRKAB1 PRKAB1 ACSBG1 ACSBG1 G6PC3 G6PC3 LEPR LEPR SOCS3 SOCS3 ADIPOR1 ADIPOR1 NFKBIA NFKBIA CPT1B CPT1B SLC2A4 SLC2A4 ACSL6 ACSL6 PRKAA2 PRKAA2 PPARA PPARA AKT1 AKT1 SLC2A1 SLC2A1 CPT1A CPT1A IKBKG IKBKG TRADD TRADD TRAF2 TRAF2 ACSBG2 ACSBG2 RELA RELA AKT3 AKT3 AGRP AGRP TNFRSF1B TNFRSF1B ACSL3 ACSL3 NPY NPY STK11 STK11 PCK1 PCK1 LEP LEP CD36 CD36 PRKAG3 PRKAG3 ACACB ACACB TNFRSF1A TNFRSF1A IRS2 IRS2 MAPK9 MAPK9 NFKBIB NFKBIB PCK2 PCK2 AKT2 AKT2 JAK2 JAK2 RXRB RXRB IRS4 IRS4 MAPK8 MAPK8 PRKCQ PRKCQ PTPN11 PTPN11 ACSL1 ACSL1 IKBKB IKBKB MTOR MTOR IRS1 IRS1 PRKAG1 PRKAG1 PRKAB2 PRKAB2 CPT1C CPT1C ACSL4 ACSL4 G6PC G6PC ADIPOQ ADIPOQ CHUK CHUK POMC POMC PPARGC1A PPARGC1A PRKAG2 PRKAG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADIPOR2Adiponectin receptor 2. (386 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
STAT3Signal transducer and activator of transcription. (802 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
RXRGRetinoid X receptor gamma. (463 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ACSBG1Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. (758 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
LEPRLeptin receptor. (1163 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
CPT1BUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (559 aa)
ACSL6AMP-binding domain-containing protein. (722 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (669 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
AGRPAgouti related neuropeptide. (132 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
NPYNeuropeptide Y. (97 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
ACACBAcetyl-CoA carboxylase beta. (2375 aa)
TNFRSF1AUncharacterized protein. (455 aa)
IRS2Insulin receptor substrate 2. (1279 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
RXRBRetinoid X receptor beta. (537 aa)
IRS4Insulin receptor substrate 4. (1222 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (698 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PRKAG1Uncharacterized protein. (331 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
POMCProopiomelanocortin. (265 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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