STRINGSTRING
PRKAA1 PRKAA1 PLCB4 PLCB4 PYGB PYGB CREB5 CREB5 ADCY2 ADCY2 G6PC2 G6PC2 GYS2 GYS2 PRKAB1 PRKAB1 ATF2 ATF2 LDHAL6A LDHAL6A CALM3 CALM3 CALML4 CALML4 CAMK2D CAMK2D PPP4C PPP4C GYS1 GYS1 G6PC3 G6PC3 ENSMFAP00000009633 ENSMFAP00000009633 PRKACA PRKACA PPP4R3A PPP4R3A PYGL PYGL PPP3CC PPP3CC CALML3 CALML3 CPT1B CPT1B FBP2 FBP2 PDHA2 PDHA2 GCGR GCGR PRKACG PRKACG CREB3L1 CREB3L1 PFKFB1 PFKFB1 PPP3R1 PPP3R1 PRKAA2 PRKAA2 PPARA PPARA ENSMFAP00000017342 ENSMFAP00000017342 AKT1 AKT1 SLC2A1 SLC2A1 CPT1A CPT1A LDHB LDHB SIK1 SIK1 PGAM2 PGAM2 PPP3CB PPP3CB PDHB PDHB FBP1 FBP1 AKT3 AKT3 ITPR2 ITPR2 CREB3L2 CREB3L2 CAMK2A CAMK2A PDHA1 PDHA1 PLCB1 PLCB1 PRMT1 PRMT1 PHKB PHKB GNAS GNAS PCK1 PCK1 PDE3B PDE3B GCK GCK PRKACB PRKACB PHKA2 PHKA2 PRKAG3 PRKAG3 FOXO1 FOXO1 PKM PKM CREB3 CREB3 ENSMFAP00000027000 ENSMFAP00000027000 ENSMFAP00000027007 ENSMFAP00000027007 PLCB3 PLCB3 PHKG1 PHKG1 SIK2 SIK2 ACACA ACACA ACACB ACACB ITPR1 ITPR1 PFKL PFKL PLCB2 PLCB2 PCK2 PCK2 PGAM1 PGAM1 AKT2 AKT2 PPP3CA PPP3CA GNAQ GNAQ LDHC LDHC PHKG2 PHKG2 CREBBP CREBBP PPP4R3B PPP4R3B PFKM PFKM SLC2A2 SLC2A2 PHKA1 PHKA1 SIRT1 SIRT1 CRTC2 CRTC2 LDHA LDHA GCG GCG ITPR3 ITPR3 CALML6 CALML6 PRKAG1 PRKAG1 CREB3L3 CREB3L3 PRKAB2 PRKAB2 CPT1C CPT1C PYGM PYGM CREB1 CREB1 EP300 EP300 G6PC G6PC ATF4 ATF4 PPARGC1A PPARGC1A PRKAG2 PRKAG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LDHAL6AL-lactate dehydrogenase A-like 6B; Belongs to the LDH/MDH superfamily. LDH family. (332 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CALML4Calmodulin like 4. (193 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PPP4R3AProtein phosphatase 4 regulatory subunit 3A. (833 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
CPT1BUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (300 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (491 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
PPP3R1Uncharacterized protein. (189 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
ENSMFAP00000017342Uncharacterized protein. (235 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
LDHBL-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (334 aa)
SIK1Uncharacterized protein. (785 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (341 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. (433 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
GNASGNAS complex locus. (1023 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PDE3BPhosphodiesterase. (1117 aa)
GCKPhosphotransferase. (480 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
FOXO1Forkhead box O1. (655 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
ENSMFAP00000027000Pyruvate kinase; Belongs to the pyruvate kinase family. (142 aa)
ENSMFAP00000027007Ldh_1_N domain-containing protein. (197 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (421 aa)
SIK2Salt inducible kinase 2. (926 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
ACACBAcetyl-CoA carboxylase beta. (2375 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (256 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GNAQG protein subunit alpha q. (359 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
CREBBPCREB binding protein. (2442 aa)
PPP4R3BProtein phosphatase 4 regulatory subunit 3B. (849 aa)
PFKMATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1227 aa)
SIRT1Sirtuin 1. (743 aa)
CRTC2CREB regulated transcription coactivator 2. (694 aa)
LDHAL-lactate dehydrogenase A chain. (337 aa)
GCGGlucagon. (180 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CALML6Calmodulin like 6. (181 aa)
PRKAG1Uncharacterized protein. (331 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (301 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
PYGMGlycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). (842 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
EP300E1A binding protein p300. (2414 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ATF4Activating transcription factor 4. (351 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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