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CACNA1S CACNA1S ORAI1 ORAI1 PTGER4 PTGER4 PLCB4 PLCB4 EDNRA EDNRA ADCY6 ADCY6 EDN2 EDN2 CLCA1 CLCA1 CLCA2 CLCA2 CALM3 CALM3 CALML4 CALML4 EDN1 EDN1 PTGER2 PTGER2 GNAI1 GNAI1 REN REN ADORA1 ADORA1 ENSMFAP00000009633 ENSMFAP00000009633 PRKACA PRKACA PPP3CC PPP3CC CALML3 CALML3 AGT AGT KCNJ2 KCNJ2 CTSB CTSB ADRB2 ADRB2 PRKACG PRKACG CLCA4 CLCA4 PPP3R1 PPP3R1 GUCY1A1 GUCY1A1 GNAI2 GNAI2 PPP3CB PPP3CB NPR1 NPR1 PDE1B PDE1B ITPR2 ITPR2 PDE3A PDE3A NPPA NPPA PLCB1 PLCB1 GNAS GNAS PDE3B PDE3B PRKACB PRKACB GUCY1B1 GUCY1B1 ADCYAP1 ADCYAP1 PLCB3 PLCB3 KCNMA1 KCNMA1 LOC101865639 LOC101865639 AGTR1 AGTR1 ACE ACE ITPR1 ITPR1 CACNA1F CACNA1F PLCB2 PLCB2 ADCY5 ADCY5 PPP3CA PPP3CA GNAQ GNAQ PDE1A PDE1A GUCY1A2 GUCY1A2 GNAI3 GNAI3 PRKG2 PRKG2 PDE1C PDE1C ITPR3 ITPR3 CALML6 CALML6 EDN3 EDN3 ADRB3 ADRB3 CACNA1D CACNA1D CREB1 CREB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (289 aa)
PTGER4Prostaglandin E2 subtype EP4 receptor; Belongs to the G-protein coupled receptor 1 family. (490 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
EDN2Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. (178 aa)
CLCA1Chloride channel accessory 1. (913 aa)
CLCA2Chloride channel accessory 2. (943 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CALML4Calmodulin like 4. (193 aa)
EDN1Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (211 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
GNAI1G protein subunit alpha i1. (422 aa)
RENRenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (485 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
CTSBCathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. (339 aa)
ADRB2Adrenergic receptor beta 2. (415 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
CLCA4Chloride channel accessory 4. (917 aa)
PPP3R1Uncharacterized protein. (189 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
NPR1Guanylate cyclase. (1061 aa)
PDE1BPhosphodiesterase. (538 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
PDE3APhosphodiesterase. (1141 aa)
NPPANatriuretic peptide A. (137 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNASGNAS complex locus. (1023 aa)
PDE3BPhosphodiesterase. (1117 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (642 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1285 aa)
LOC101865639Uncharacterized protein. (317 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
ACEAngiotensin-converting enzyme. (1307 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GNAQG protein subunit alpha q. (359 aa)
PDE1APhosphodiesterase. (545 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (730 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
PDE1CPhosphodiesterase. (768 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CALML6Calmodulin like 6. (181 aa)
EDN3Endothelin 3. (211 aa)
ADRB3Adrenergic receptor beta 3. (418 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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